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Comparing Eligard vs Xtandi

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Eligard leuprolide

Xtandi enzalutamide

Prescribed for Prostate Cancer. Eligard may also be used for purposes not listed in this medication guide.

Xtandi is an androgen receptor inhibitor that is usually used in conjunction with androgen deprivation therapy for the treatment of prostate cancer. The main side effects are weakness or lack of... View more

Prescription only

Ratings & Reviews

View all 22 reviews

View all 10 reviews

Drug Class

Side Effects

See the full Eligard side effects document.

Common side effects include: upper respiratory tract infection, headache, hot flash, laryngitis, nasopharyngitis, pharyngitis, rhinitis, and sinusitis.

See the full Xtandi side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	1 powder for injection, extended release
Dosage	7.5 mg/month
Per Unit^*	$480.07 - $481.07
Cost^*	$480.07 - $481.07

View all Eligard prices and generic prices

Quantity	120 capsule
Dosage	40 mg
Per Unit^*	$106.88
Cost^*	$12,825.33

View all Xtandi prices

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Generic Availability

Yes

Dosage Form(s) Available

Subcutaneous powder for injection, extended release

Oral capsule

Brand Names

Other leuprolide brands include: Fensolvi, Lupron Depot, Lupron Depot-PED

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

4.25 hours

244.8 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

FDA Alerts

N/A

Drug Interactions

A total of 259 drugs are known to interact with Eligard:

53 major drug interactions (145 brand and generic names)
204 moderate drug interactions (788 brand and generic names)
2 minor drug interactions (11 brand and generic names)

A total of 571 drugs are known to interact with Xtandi:

176 major drug interactions (484 brand and generic names)
382 moderate drug interactions (1603 brand and generic names)
13 minor drug interactions (48 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

N/A

August 31, 2012

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer