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Xtandi Disease Interactions

There are 2 disease interactions with Xtandi (enzalutamide).


Enzalutamide (applies to Xtandi) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Enzalutamide has not been assessed in patients with severe renal impairment or end-stage renal disease. Caution is advised if used on these patients. No initial dosage adjustment is required on patients with mild to moderate renal impairment.


  1. "Product Information. Xtandi (enzalutamide)." Astellas Pharma US, Inc (2012):

Enzalutamide (applies to Xtandi) seizures

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Cerebrovascular Disease, Head Injury, Brain/Intracranial Tumor, CNS Infection

Seizures occurred in 0.5% of patients receiving enzalutamide in clinical trials. Patients with predisposing factors for seizures were generally excluded. Caution is advised if using in patients with possible predisposing factors such as history of seizures, history of trauma or head injury, cerebrovascular accident or transient ischemic attack, Alzheimer's disease, meningioma or brain tumor or infection, and any unexplained loss of consciousness in the past 12 months. Enzalutamide should be discontinued permanently in any patient who develops a seizure during treatment.


  1. "Product Information. Xtandi (enzalutamide)." Astellas Pharma US, Inc (2012):

Xtandi drug interactions

There are 616 drug interactions with Xtandi (enzalutamide).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.