Comparing Dulaglutide vs Semaglutide

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Dulaglutide	Semaglutide	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Dulaglutide	Semaglutide	Enter another drug to compare
Prescription only Dulaglutide mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more	Prescription only Semaglutide (Ozempic, Rybelsus) lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the... View more	Related suggestions Weight Loss (Obesity/Overweight) Phentermine Wegovy Mounjaro Topiramate Zepbound Ozempic Type 2 Diabetes Metformin Ozempic Rybelsus Mounjaro Tirzepatide Januvia Cardiovascular Risk Reduction Simvastatin Ozempic Repatha Wegovy Jardiance Evolocumab
More about Dulaglutide	More about Semaglutide
Ratings & Reviews
Dulaglutide has an average rating of 5.3 out of 10 from a total of 993 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect.	Semaglutide has an average rating of 6.9 out of 10 from a total of 2690 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 20% reported a negative effect.
View all 993 reviews	View all 2690 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Nausea (40.3%) Diarrhea (24.2%) Vomiting (18.4%) Loss of appetite (11.1%) Burping (8.8%) Upset stomach (8.8%) Headaches (7.9%) View all Dulaglutide side effects	Nausea (33.5%) Constipation (15.1%) Diarrhea (14.9%) Vomiting (10.9%) Headaches (6.7%) Burping (6.7%) Upset stomach (6.2%) View all Semaglutide side effects
Drug Class
GLP-1 Agonists (Incretin Mimetics)	GLP-1 Agonists (Incretin Mimetics)
Generic Availability
N/A	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
N/A	N/A
Brand Names
Trulicity	Ozempic, Rybelsus, Wegovy
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
120 hours	168 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.
Drug Interactions
A total of 272 drugs are known to interact with Dulaglutide: 15 major drug interactions (34 brand and generic names) 255 moderate drug interactions (1450 brand and generic names) 2 minor drug interactions (14 brand and generic names)	A total of 273 drugs are known to interact with Semaglutide: 15 major drug interactions (34 brand and generic names) 257 moderate drug interactions (1453 brand and generic names) 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Dulaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more Talk to your doctor before using alcohol together with dulaglutide. Alcohol may affect blood... View more	Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
Disease Interactions
Gastroparesis Pancreatitis Thyroid carcinoma Renal dysfunction	Suicidal behavior and ideation Thyroid cancer GI adverse events Hypoglycemia Pancreatitis Retinopathy
First Approval Date
September 18, 2014	December 05, 2017
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Support group En español	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Support group
Patient Resources
Dulaglutide uses	Semaglutide uses
Professional Resources
Monograph (AHFS) Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Cardiovascular Risk Reduction Type 2 Diabetes Weight Loss (Obesity/Overweight)	Weight Loss (Obesity/Overweight) Chronic Kidney Disease Cardiovascular Risk Reduction Type 2 Diabetes

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Dulaglutide vs Semaglutide

See also:

Jardiance

Xarelto

Ozempic

Rybelsus

Trulicity

Brilinta

Victoza

Saxenda

Colchicine

Semaglutide

Further information

Comparing Dulaglutide vs Semaglutide

See also:

Further information

Compare Drugs