Comparing Contrave vs Rybelsus
| Contrave (bupropion / naltrexone) | Rybelsus (semaglutide) |
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| Contrave (bupropion / naltrexone) | Rybelsus (semaglutide) |
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Prescription only
Prescribed for Weight Loss (Obesity/Overweight). Contrave may also be used for purposes not listed in this medication guide. |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
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| More about Contrave (bupropion / naltrexone) | More about Rybelsus (semaglutide) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Contrave has an average rating of 6.6 out of 10 from a total of 1988 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 25% reported a negative effect. |
Rybelsus has an average rating of 6.4 out of 10 from a total of 283 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Contrave side effects |
View all Rybelsus side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Contrave prices |
View all Rybelsus prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Other semaglutide brands include: Ozempic, Wegovy | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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21 hours |
168 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 779 drugs are known to interact with Contrave:
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A total of 273 drugs are known to interact with Rybelsus:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 10, 2014 |
September 20, 2019 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.