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Contrave Side Effects

Generic Name: bupropion / naltrexone

Note: This document contains side effect information about bupropion / naltrexone. Some of the dosage forms listed on this page may not apply to the brand name Contrave.

For the Consumer

Applies to bupropion / naltrexone: oral tablet extended release

Along with its needed effects, bupropion / naltrexone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bupropion / naltrexone:

More common
  • Blurred vision
  • discouragement
  • dizziness
  • fear or nervousness
  • feeling sad or empty
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • pounding in the ears
  • slow or fast heartbeat
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness or weakness
Less common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain
  • shakiness in the legs, arms, hands, or feet
  • trembling or shaking of the hands or feet
Less common or rare
  • Chest pain or discomfort
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • sweating
  • vomiting
Rare
  • Changes in behavior
  • thoughts of killing oneself
Incidence not known
  • Aggressive or angry
  • anxiety
  • blistering, peeling, or loosening of the skin
  • chills
  • clay colored stools
  • cough
  • dark urine
  • delusions of persecution, mistrust, suspiciousness, or combativeness
  • diarrhea
  • difficulty with moving
  • difficulty with swallowing
  • dry mouth
  • false beliefs that cannot be changed by facts
  • feeling that others are watching you or controlling your behavior
  • feeling, seeing, or hearing things that are not there
  • fever
  • hives, itching, or rash
  • hyperventilation
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle stiffness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • restlessness
  • severe mood or mental changes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain or tenderness
  • swelling of the feet or lower legs
  • tightness in the chest
  • unusual behavior
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking bupropion / naltrexone:

Symptoms of overdose
  • Blue lips, fingernails, or skin
  • change in or loss of consciousness
  • confusion
  • decreased awareness or responsiveness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • muscle cramps or spasms
  • severe sleepiness

Some side effects of bupropion / naltrexone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement
Less common
  • Change or loss of taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • feeling of warmth
  • hearing loss
  • increased sweating
  • redness of the face, neck, arms, and occasionally, upper chest
  • stomach pain
Less common or rare
  • Feeling of constant movement of self or surroundings
  • indigestion
  • sensation of spinning
  • severe nausea or vomiting
  • thinning of the hair or hair loss

For Healthcare Professionals

Applies to bupropion / naltrexone: oral tablet extended release

Psychiatric

Very common (10% or more): Sleep disorders (up to 13.8%)
Common (1% to 10%): Depression, anxiety, irritability
Uncommon (0.1% to 1%): Insomnia, abnormal dreams, nervousness, dissociation (feeling spacey), tension, agitation, mood swings
Rare (less than 0.1%): Suicidal ideation[Ref]

Nervous system

Very common (10% or more): Headache (up to 17.6%), dizziness (up to 10.4%)
Common (1% to 10%): Tremor, dysgeusia, attention disorders
Uncommon (0.1% to 1%): Vertigo, motion sickness, disturbance in attention, lethargy, intention tremor, balance disorder, memory impairment, amnesia, mental impairment, presyncope/syncope, hernia, seizure[Ref]

Cardiovascular

Common (1% to 10%): Hot flush, hypertension, increased blood pressure, palpitations
Uncommon (0.1% to 1%): Tachycardia, myocardial infarction
Frequency not reported: Increased heart rate[Ref]

Hepatic

Uncommon (0.1% to 1%): Cholecystitis, increased hepatic enzymes[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, rash
Uncommon (0.1% to 1%): Alopecia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 32.5%), constipation (up to 19.2%), vomiting (up to 10.7%)
Common (1% to 10%): Dry mouth, diarrhea, upper abdominal pain, viral gastroenteritis, abdominal pain
Uncommon (0.1% to 1%): Lower abdominal pain, eructation, lip swelling, hematochezia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Vaginal hemorrhage, irregular menstruation, erectile dysfunction, vulvovaginal dryness[Ref]

Hematologic

Uncommon (0.1% to 1%): Decreased hematocrit[Ref]

Immunologic

Common (1% to 10%): Influenza[Ref]

Metabolic

Uncommon (0.1% to 1%): Dehydration[Ref]

Musculoskeletal

Common (1% to 10%): Muscle strain
Uncommon (0.1% to 1%): Intervertebral disc protrusion, jaw pain[Ref]

Other

Common (1% to 10%): Fatigue, tinnitus
Uncommon (0.1% to 1%): Feeling jittery, feeling abnormal, asthenia, thirst, feeling hot, staphylococcal infection[Ref]

Renal

Uncommon (0.1% to 1%): Kidney infection, increased blood creatinine, increased serum creatinine, micturition urgency[Ref]

Respiratory

Uncommon (0.1% to 1%): Pneumonia[Ref]

References

1. "Product Information. Contrave (buPROPion-naltrexone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Some side effects of Contrave may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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