Comparing Bactrim vs Macrobid
| Bactrim (sulfamethoxazole / trimethoprim) | Macrobid (nitrofurantoin) |
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| Bactrim (sulfamethoxazole / trimethoprim) | Macrobid (nitrofurantoin) |
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Prescription only
Bactrim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be higher in the elderly... View more |
Prescription only
Prescribed for Urinary Tract Infection, Prevention of Bladder infection, Bladder Infection. Macrobid may also be used for purposes not listed in this medication guide. |
Related suggestions Urinary Tract Infection
Prevention of Bladder infection (Cystitis Prophylaxis)
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| More about Bactrim (sulfamethoxazole / trimethoprim) | More about Macrobid (nitrofurantoin) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Bactrim has an average rating of 5.4 out of 10 from a total of 616 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 43% reported a negative effect. |
Macrobid has an average rating of 4.5 out of 10 from a total of 827 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 51% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Bactrim side effects |
View all Macrobid side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Bactrim prices |
View all Macrobid prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other sulfamethoxazole / trimethoprim brands include: Bactrim DS, Bactrim IV, Bactrim Pediatric, Bethaprim, Bethaprim Pediatric, Co-trimoxazole, Septra, Septra DS, SMZ-TMP DS, Sulfatrim Pediatric View more | Other nitrofurantoin brands include: Furadantin, Macrodantin | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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14 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 452 drugs are known to interact with Bactrim:
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A total of 220 drugs are known to interact with Macrobid:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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July 30, 1973 |
December 24, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.