Comparing Bactrim vs Macrobid
| Bactrim (sulfamethoxazole / trimethoprim) | Macrobid (nitrofurantoin) |
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| Bactrim (sulfamethoxazole / trimethoprim) | Macrobid (nitrofurantoin) |
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Prescription only
Bactrim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be higher in the elderly... View more |
Prescription only
Prescribed for Urinary Tract Infection, Prevention of Bladder infection, Bladder Infection. Macrobid may also be used for purposes not listed in this medication guide. |
Related suggestions Urinary Tract Infection
Prevention of Bladder infection (Cystitis Prophylaxis)
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| More about Bactrim (sulfamethoxazole / trimethoprim) | More about Macrobid (nitrofurantoin) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Bactrim has an average rating of 5.4 out of 10 from a total of 616 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 43% reported a negative effect. |
Macrobid has an average rating of 4.5 out of 10 from a total of 827 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 51% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Bactrim side effects |
View all Macrobid side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Bactrim prices |
View all Macrobid prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other sulfamethoxazole / trimethoprim brands include: Bactrim DS, Bactrim IV, Bactrim Pediatric, Bethaprim, Bethaprim Pediatric, Co-trimoxazole, Septra, Septra DS, SMZ-TMP DS, Sulfatrim Pediatric View more | Other nitrofurantoin brands include: Furadantin, Macrodantin | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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14 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 455 drugs are known to interact with Bactrim:
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A total of 222 drugs are known to interact with Macrobid:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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July 30, 1973 |
December 24, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.