Comparing Afrezza vs Rybelsus

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Afrezza (insulin inhalation, rapid acting)	Rybelsus (semaglutide)	Enter another drug to compare

Afrezza (insulin inhalation, rapid acting)

Rybelsus (semaglutide)

Prescription only

Prescribed for Diabetes - Type 1, Type 2 Diabetes. Afrezza may also be used for purposes not listed in this medication guide.

Prescription only

Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more

More about Afrezza (insulin inhalation, rapid acting)

More about Rybelsus (semaglutide)

Ratings & Reviews

Afrezza has an average rating of 6.2 out of 10 from a total of 37 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 35% reported a negative effect.

Rybelsus has an average rating of 6.5 out of 10 from a total of 300 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect.

View all 37 reviews

View all 300 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Afrezza side effects

Nausea (41.7%)
Diarrhea (21.3%)
Constipation (17.0%)
Loss of appetite (9.7%)
Vomiting (8.7%)
Stomach pain (5.7%)
Upset stomach (5.3%)

View all Rybelsus side effects

Drug Class

Insulin

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

N/A

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	90 powder
Strength	4 units
Per unit^*	$5.73
Cost^*	$515.49

View all Afrezza prices

Quantity	30 tablet
Strength	3 mg
Per unit^*	$35.83
Cost^*	$1,074.94

View all Rybelsus prices

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Dosage Forms

Inhalation powder

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

N/A

168 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 420 drugs are known to interact with Afrezza:

15 major drug interactions (39 brand and generic names)
384 moderate drug interactions (1990 brand and generic names)
21 minor drug interactions (210 brand and generic names)

A total of 273 drugs are known to interact with Rybelsus:

15 major drug interactions (34 brand and generic names)
257 moderate drug interactions (1452 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

N/A

September 20, 2019

WADA Class View classifications

N/A

More Information

Patient Resources

Afrezza uses

Rybelsus uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Afrezza vs Rybelsus

See also:

Ozempic

Rybelsus

Mounjaro

Lantus

Tresiba

Humalog

Levemir

Basaglar

Novolog

Toujeo SoloStar

Further information

Comparing Afrezza vs Rybelsus

See also:

Further information

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