Venlafaxine and Depression: What Users Say

• Taw...
• Taken for 1 to 6 months
• February 18, 2020

Venlafaxine for Depression "I take 150mg time-released Effexor. I am dealing with a head injury for 6 months now. I have been on Effexor since. I have no side effects, and it has really helped me with my anxiety, nervousness, and depression. This medicine is such a lifesaver. I can go to work and be around people. I don’t know where I would be without this medication."

• aim...
• February 25, 2020

Venlafaxine for Anxiety "I'm a 27 y/o female, good health but have GAD and MDD. I began taking Effexor XR when I began having panic attacks while driving. I began with 37.5mg for 4 weeks, then upped to 75mg after that. After 3 months, I began to sweat in my sleep despite not feeling overheated. I began to suffer from sexual dysfunction, lost my libido and had difficulty reaching an orgasm (neither had been an issue previously). My appetite increased and I gained 25 lbs in 1 year. I also noticed I felt very 'flat' emotionally. I wrote this because I feel like positive reviews are lacking. Effexor absolutely improved my anxiety. The side effects were unpleasant but not severe. Stopping this medication suddenly can cause withdrawal symptoms, so when I switched to a new one, I slowly tapered off it by opening the capsule and counting the granules, reducing them by about 4 per day. I did not suffer from any 'brain zaps' or any withdrawal symptoms."

• Nat...
• October 21, 2019

Venlafaxine for Depression "I have struggled with eating disorders (Anorexia and Binging) for about 4 years now. It started at 16 and slowly began to follow me into college. I’ve struggled with relationships and often find myself extremely depressed and more anxious than ever. I started Effexor about 2 weeks ago now, and the first few days were much like the experiences listed on here. I have done MDMA before, and it does feel like that for the first two days. However, after I got through that stage, each day has been getting better. Colors seem brighter, and my motivation has started to get better. Before, I had struggled with finding any interest in life, and everything seems a little bit more open each day I wake up. I do have some very vivid dreams and find that during the night, my depression gets a little worse, but it has slowly subsided, and I’m able to push away thoughts that normally frustrate me. I’m excited to see how each day goes moving forward."

• Nur...
• Taken for 1 to 2 years
• May 26, 2016

Venlafaxine for Major Depressive Disorder "I have been taking Effexor for 13 months now. Initially, I was prescribed 75 mg while hospitalized at an inpatient psychiatric facility, but that was increased to 150 mg by the time I was discharged. Never in my life have I felt this way - normal!! My crying spells, anhedonia, suicidal ideations, psychosis... it's all gone, gone, gone! This medication has saved my life. I am so happy to take my meds every morning."

• Cat...
• Taken for 1 to 6 months
• November 7, 2019

Venlafaxine for Generalized Anxiety Disorder "I started 75 mg Effexor about three months ago for GAD and major depression. It has done wonders for me. The first month, I did yawn a lot and seemed to be experiencing the emotional blunting that they described. At one point, I was scared that I had lost all empathy, but I realized that being overzealous about others' opinions and worries was destroying me. I am a lot more carefree, and I haven't cried for no reason in over three months. The low dose is working, and I am much happier overall. I do sleep a lot, almost 9 hours a night, and I am slow to rise. But my day carries on well after that. I would consider this a success."

• anx...
• May 9, 2016

Venlafaxine for Anxiety "I've had anxiety/panic attacks and depression for over 20 years now. My anxiety was so bad I had to be homeschooled. I've taken Prozac, Paxil, and neither worked and had bad mood swings on Paxil. My doctor suggested something newer, it was Effexor. He said he has had good results with it. So I tried it, heck I would've tried anything to make my anxiety go away. I was on Effexor (75mg) for 10 years, and it worked for me. No side effects except being tired at first. No more anxiety/panic attacks or depression but maybe a very few short episodes. I was happy and enjoying things I was held back from for so many years. Effexor changed my life, literally. If I did miss a dose, I felt tired, depressed, and the 'zaps.'"

• Anonymous
• Taken for 1 to 6 months
• December 3, 2012

Venlafaxine for Anxiety "I have been on Effexor XR for about 3 months now (75mg), and it's done a great job of controlling my anxiety. For the first couple of days, my anxiety skyrocketed, but I supplemented with Ativan to help with that. Then on the third day, I woke up and felt totally normal. It does make me a bit tired, but I also sleep better - and I do have very vivid dreams at times (not scary, just vivid). It also makes me a bit apathetic, but it's better than living in a constant state of anxiety. I'd had bad reactions to Lexapro and Zoloft, so I was happy to find something that worked. I hope to come off someday, but for now, it's giving me what I need."

• Mar...
• Taken for less than 1 month
• January 9, 2020

Venlafaxine for Major Depressive Disorder "I am delighted with the result of venlafaxine. I had a breakdown and visited my GP in desperation due to panic attacks, depression, crippling anxiety, heavy drinking, and an addiction to codeine. The side effects were initially a bit uncomfortable, but they have settled. I am lacking motivation, but I have only been on it for 2 weeks, and I figure I need some time to recover from my breakdown, so I’m just going with it for now. It has made me feel so much calmer, it has stopped me from drinking and taking codeine, which I was using to self-medicate. This medication has saved my life. I’ve given it a 9, as my libido is suffering."

• ale...
• August 6, 2012

Venlafaxine for Anxiety "I took Effexor XR after I gave up on Lexapro (it didn't work for me, I waited for a couple of months). I started at 75 mg and 10 days later increased to 150 mg. I have been at 150 mg for about 5 months. I feel that I am at a stable point, so I don't want to change anything for a while. My doctor said to start weaning off, but I don't think I'm ready yet. I had gone through a gut-wrenching episode in my life that lasted for about 4 intense months of sleepless nights, hot sweats, heart palpitations, heavy chest, lack of concentration, and sadness. I felt as if I was at the doctor every other day trying to figure out what was wrong. My anxieties were so bad that I felt like exploding. Thankfully I waited it out, and Effexor has helped."

• Jos...
• June 27, 2013

Venlafaxine for Depression "I am a 60-year-old male who has suffered from depression and panic attacks. In my late 30s, I decided to seek help. Like many others, the list of medications my doctors tried would fill a dictionary. Some worked for a while. I refused to take lithium. In my late 40s, I was also diagnosed with ADD. I now use 4 medications successfully: Effexor XR 450 mg daily, Xanax 1 mg daily, Adderall XR 60 mg daily, and Strattera 25 mg daily. I am now free of both depression and panic attacks for nearly 10 years! I am comfortable in public speaking and find that I love the adrenaline rush! I've tried to stop using Effexor XR but always restarted because of the horrible depression. Withdrawal is like a bad acid trip. Use Effexor to stay alive!"

• SLi...
• Taken for 5 to 10 years
• January 10, 2020

Venlafaxine for Depression "Please, please, please take my advice. If Effexor is working for you, don't quit! I took Effexor for 8 great years (anxiety and depression). Tapered and quit. Started again two months later to be on the safe side while going through a stressful period at work. Within 24 hours, my life fell totally apart. Anxiety and depression through the roof. 18 months and 4 AD's later, I am still a wreck. Losing hope."

• ssh...
• Taken for 10 years or more
• October 3, 2019

Venlafaxine for Depression "Started weaning off Effexor 150mg 1 year ago. Got to 37.5mg with hardly any side effects. Then weaning off 37.5mg was terrible. Headache/head pounding, nausea, vertigo, diarrhea, extreme tiredness, random crying spells, very emotional, etc. Did a lot of research and trusted that it’d get easier with time. 4 wks later, finally feeling physically well again... Then it got bad. Sense of constant dread, horrible anxiety, heart racing, emotional as hell, trouble sleeping, extremely depressed, and felt like a zombie. Missing work, sleeping all day, no motivation to do anything. Went back to doc and she put me back on the 37.5mg. Extremely disappointed not to get off this medication. Been 3 days since getting back on it, starting to feel somewhat normal again, just want my life back. Wish I’d received more info when I was first prescribed it - had no idea it would be such a nightmare to try to get off of it. This experience has shaken up my whole world. BEWARE."

• Ste...
• Taken for 6 months to 1 year
• August 25, 2020

Venlafaxine for Depression "I was put on a starting dose of 75 mg Effexor XR and worked my way up to a dose of 150 mg. I couldn't sleep, and my mind was racing. I wasn't myself at all. Back on 75 mg now, and I feel better than that, but still depressed. Switching meds soon, I hope."

• Dis...
• Taken for 10 years or more
• July 28, 2012

Venlafaxine for Anxiety "I have been on this medication for over 15 years. I can tell you that this is the absolute best medication for panic attacks. The problem is that I never had any panic attacks until I quit taking the pill after a year of use. I was prescribed this when I was 18 after being hospitalized as a result of several traumatic events. I started on 32 mg and eventually was bumped up to 150 mg and then 225 mg. I weaned off and survived the withdrawals and felt amazing. Seriously, it felt like the best moment of my life, but about a year after I stopped taking it, the depression came back twice as bad."

• j1a...
• Taken for 1 to 6 months
• October 13, 2014

Venlafaxine for Depression "Celexa stopped working, and I was put on Effexor. My panic attacks are worse than they have ever been, my depression is totally off the charts, and I physically shake all the time. The irritability is by far the worst part for me. I'm forever angry now on this medication. My friends and family have noticed a big difference in my personality. I'm definitely getting off this medication!"

• Plu...
• October 22, 2016

Venlafaxine for Depression "I am extremely disheartened in reading the negative reviews. I have taken Effexor since 1993. I began taking 37.5 mg and later lived for one year in a private psychiatric hospital for a suicide attempt. My psychiatrist, then the President of the American Psychiatric Association, increased my dose to 600 mg per day. This miracle drug kept and still keeps me alive some 23 years later. I have experimented with not taking this or any medication. I never presented with any withdrawal symptoms. However, like clockwork, on the 3rd day w/o it, I begin to cry tears over nothing. By the 4th day, I find myself in the midst of severe depression. Within an hour of beginning my regimen again, I am back to my normal. Do not be afraid to try this medication."

• Che...
• Taken for 2 to 5 years
• July 10, 2014

Venlafaxine for Major Depressive Disorder "I started taking Effexor at age 19 after about 2 1/2 years on Prozac. The reason for the switch was that I developed anxiety problems at that age in addition to depression, and the Prozac was not treating the anxiety. Effexor works very well to treat both anxiety and depression, but if I stop taking it for even 1-2 days (which is often because I am very forgetful), I become extremely depressed for the next 1-2 days. Right now, I am in one such downswing after taking my Effexor for the first time in about 5 days. If you avoid doing that, though, you should be fine, the medication does help a lot."

• Fre...
• February 10, 2017

Venlafaxine for Major Depressive Disorder "I never write reviews, but I figured I had to share how truly life-changing Effexor has been for me. I've suffered with GAD and Major Depressive Disorder for quite some time. I was on and off of Prozac for about five years. When it stopped working, I began taking Effexor XR 37.5 mg. I started feeling better, more calm, less anxious. Last year, someone I had dated for years and had recently broken up with passed away tragically. I was a disaster. My dosage was increased to 75 mg, then 150 mg, and now 225 mg. Honestly, I don't know how I would have made it to where I am today without this medication. It has controlled my anxiety, my panic attacks, and my depression. I still have bad days, I'm still in mourning, but I finally feel normal."

• Fre...
• February 10, 2017

Venlafaxine for Major Depressive Disorder "I never write reviews, but I figured I had to share how truly life-changing Effexor has been for me. I've suffered with GAD and Major Depressive Disorder for quite some time. I was on and off of Prozac for about five years. When it stopped working, I began taking Effexor XR 37.5 mg. I started feeling better, more calm, less anxious. Last year, someone I had dated for years and had recently broken up with passed away tragically. I was a disaster. My dosage was increased to 75 mg, then 150 mg, and now 225 mg. Honestly, I don't know how I would have made it to where I am today without this medication. It has controlled my anxiety, my panic attacks, and my depression. I still have bad days, I'm still in mourning, but I finally feel normal."

• bis...
• Taken for 2 to 5 years
• December 15, 2018

For Anxiety and Stress "Weird drug. I think it helped at first and really eased a lot of the really dim days initially. I continued to take it over the course of several years, and in hindsight, I don't think it was quite right for me. I became a bit out of character, high-strung, and weird. Maybe slightly bipolar but possibly a reaction to very difficult times and lots of change. Some of my worst periods of mental illness were on this stuff; my doctor had me on 300 mg+ at one point, things were very flat, dysphoric, and my adrenals were certainly working. I was a bit suicidal and a little detached at points. I eventually ditched it, experienced some lack of energy, brain-zappy withdrawal for a while. I spent a few months drug-free, then found meds I suit a lot better. If you're still feeling depressed/despaired and it seems like your perception of the world has become cold/weird and you're agitated, I strongly advise you to speak to your doctor and try something new."

• BAC...
• April 19, 2016

Venlafaxine for Depression "It changed my life. 48 years of just dealing with anxiety and depression, not wanting to be on medication. With the onset of pre-menopause, the depression was unbearable and more feelings of hopelessness. My doctor prescribed 75 mg, and I feel alive again. The torment of paranoia, anxiety, and the depression are gone."

• Mis...
• July 12, 2017

For Generalized Anxiety Disorder "I am amazed by this drug. I suffer from extreme general anxiety, insomnia, as well as adult ADD. I have been on Celexa, it worked for about 6 months. Zoloft, not bad, stabilizes emotions but doesn't get rid of anxiety. Wellbutrin made me so depressed. I was actually given this drug as off-market for hot flashes while still on Zoloft. Well, I went off the Zoloft immediately because this drug worked so well. First time ever (other than taking benzos) I had no butterflies in my stomach, fear over nothing, and slept better. I can't believe the difference in finding the right drug. I don't really suffer from depression, I only get depressed because of my anxiety and chronic insomnia. This has been a miracle drug for me."

• Anonymous
• September 7, 2009

Venlafaxine for Bipolar Disorder "I think Effexor has been very beneficial for me - I've taken it for about six years. A word of warning: do NOT let your prescription run out or take yourself off Effexor abruptly! I experienced this by accident while waiting for a mail-order prescription to arrive (my doctor was just moving into a new office and didn't have samples available). Within 2 days, I was a wreck emotionally (depressive, sobbing for no reason), cognitively (all over the place, no concentration), and physically (impaired motor coordination among other things). The 'brain shivers,' a feeling like an electrical current running from the brain down the spine and back again, are very disconcerting! I got samples from my doctor's former office and was noticeably better within hours of 1 dose."

• Kay...
• September 23, 2014

Venlafaxine for Depression "Was so excited to try Effexor XL and did for the past 6 years. Well, I didn't realize that it made me anhedonia, or without feeling towards a lot of things. I just went on my merry way, but would do nothing... sat and watched TV, couldn't get anything done. Everything was just great!... that is what I thought... then I started gaining weight... gradually, but I mean 60-70# over the past 6 years or so... but just kept on eating. Then I thought I have to do something about this. I gradually took myself off, but wow the side effects of the withdrawal was unbelievable. My son told me never to do that again... and I told him see... this medication has so changed me... and I will never take that again...! Trying to lose this weight now."

• Chr...
• Taken for 1 to 6 months
• April 18, 2022

Venlafaxine for Anxiety "I used to be a person with extreme anxiety. For over a decade, I always had to rely on Xanax bars and/or Klonopin. Until my Dr. prescribed me Effexor 37.5 mgs, now almost four months later, I'm on 150 mgs, and Effexor has almost completely taken away my anxiety while at the same time has helped control my stress, agitation, and depression. I thank my Dr. for prescribing me Effexor, it has changed my life for the better."