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Lysteda and Cramps: What Users Say

Cramps: mentioned by 7 users (10.0%)

Based on user experiences from 70 Lysteda reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 24.3%
cramps 10.0%
bleeding 7.1%
blood clots 5.7%
dizziness 5.7%
irregular periods 4.3%
nausea 4.3%

Reviews for Lysteda

Commonly mentioned side effects
  • Jea...
  • July 27, 2019

For Heavy Menstrual Bleeding "I have had extremely heavy periods for at least 10 years and was anemic to the point where I was out of breath all the time. I went in to have an ablation as an in-office procedure, but the doctor could not get into my cervix, so I could not have it done. The doctor told me about this medication as an option to try. I was afraid and did not take it at first after getting the prescription. About 3 months later, I was at my wits' end, so I decided to take it and am so happy I did. My bleeding is down by 50 to 60 percent. I really only need two pills twice a day on my heaviest days to control things and to feel normal again. I have been able to do so many more activities and have not had to miss work due to the heavy bleeding. I am very busy at work and in and out of meetings all day, and this has helped me so much! This also helps my cramps, I think, because my uterus is not contracting as much due to less blood. It’s an amazing drug and has really changed my life."

9 / 10
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67 Report
  • Efs...
  • Taken for 6 months to 1 year
  • October 2, 2016

For Heavy Menstrual Bleeding "Lysteda changed my life. For years, I have experienced incredibly painful periods with debilitating blood flow. I experienced severe anemia, bruising, and menstrual cramps that caused vomiting and fainting. I would clot through super pads and tampons at least once per hour (wearing them simultaneously even overnight) for five+ days. It was impossible to even leave my house because of how often I would bleed through my clothes. My doctor recommended trying Lysteda before opting for an irreversible surgery. (I am not able to go on birth control or use implants due to a uterine deformity.) Lysteda started working immediately, within an hour. My periods last about 4 days now and I can get away with wearing just a pad. My life has changed and I am so thankful!!"

10 / 10
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72 Report
  • J B...
  • July 20, 2017

For Menstrual Disorders "This medicine is a blessing. I am 43 years old. I eat healthy and exercise every day except weekends. On March 15, 2017, I was given the depot shot for my heavy bleeding. BIG MISTAKE. From the shot, I experienced more bleeding and blood clots than I ever experienced prior to taking the shot. My bleeding continued for over 90 days. I was admitted to the hospital for low blood and had to have 4 pints of blood transfusion. On July 4, my doctor prescribed Lysteda. I did experience some cramping and back pain, but after 5 days of taking this medicine 3 times a day, my bleeding stopped completely. Now, my husband and I are much happier people!!"

10 / 10
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45 Report

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  • Deb...
  • Taken for less than 1 month
  • May 6, 2017

For Menstrual Disorders "Let me just say last month from the evening of the 1st to the morning of the 3rd I used 50 pads! A few tampons too! I started Lysteda on the evening of the 1st this month, yes it was lighter! 28 pads in 2 days. Day 3 and 4 got heavier! Today I had clotting like I've never seen in my 30 plus years of having a cycle (dollar bill size). The cramps were so bad I felt like I was in labor! I do suffer from fibroid tumors and anemia due to heavy bleeding. I'm having a hysterectomy next month, and my doctor wants me to take these pills again next month. I will not take any more of these pills! Not 1 more!"

3 / 10
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39 Report
  • 3ki...
  • Taken for 1 to 6 months
  • June 5, 2016

For Heavy Menstrual Bleeding "After researching various options with my gyn, I decided to try Lysteda. I'm on my second month with it. The first month saw horrible cramps barely controlled with Advil, etc. This month I had almost no cramps nor headaches. I was pleasantly surprised when the flow was much lighter on day 2, normally like Niagara Falls for me. But day 3 isn't really much lighter than it used to be, and my periods are longer. Does it cut the flow? Yes. Does it make mine light? No. I still lose 2 ounces per hour or two during day 3, so I'll use it while I investigate other options."

8 / 10
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22 Report

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  • Dre...
  • Taken for less than 1 month
  • January 18, 2021

For Heavy Menstrual Bleeding "I’ve suffered from heavy bleeding for years now. I do have uterine fibroids. My doctor has tried every medication under the sun for me, and this was my last option. Unfortunately, it did not work for me. I started Lysteda the first day of my cycle for three days and my cycle was actually worse. The clots were unbelievable and cramps like I was in labor. Very disappointed, I thought this would be my miracle medication. Glad it works for some. Never taking it again."

1 / 10
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10 Report
  • Anonymous
  • September 21, 2011

For Menstrual Disorders "I have been using Lysteda for the last six months. It worked great the first 3 months. But the fourth month, I started having horrible lower back pain, the cramps came back, but the flow was still light. However, the last two months, my cycle came within 2 weeks, and I have my cycle again. According to the dosage and usage, I am unsure if taking it more than 5 days is recommended. I had my cycle for 5 days, it stopped for 1 day and started back up. Tried contacting my GYN but couldn't."

4 / 10
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26 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.