Generic name: Tranexamic Acid 650mg
Dosage form: tablet
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The recommended dose of LYSTEDA for women with normal renal function is two 650 mg tablets taken three times daily (3900 mg/day) for a maximum of 5 days during monthly menstruation. LYSTEDA may be administered without regard to meals. Tablets should be swallowed whole and not chewed or broken apart.
In patients with renal impairment, the plasma concentration of tranexamic acid increased as serum creatinine concentration increased [see Clinical Pharmacology (12.3)]. Dosage adjustment is needed in patients with serum creatinine concentration higher than 1.4 mg/dL (Table 1).
|Serum Creatinine (mg/dL)||Adjusted Dose||Total Daily Dose|
|Cr above 1.4 and ≤ 2.8||1300 mg (two 650 mg tablets) two times a day for a maximum of 5 days during menstruation||2600 mg|
|Cr above 2.8 and ≤ 5.7||1300 mg (two 650 mg tablets) once a day for a maximum of 5 days during menstruation||1300 mg|
|Cr above 5.7||650 mg (one 650 mg tablet) once a day for a maximum of 5 days during menstruation||650 mg|
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