Skip to main content

Ultram and Nausea: What Users Say

Nausea: mentioned by 20 users (8.7%)

Based on user experiences from 229 Ultram reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 8.7%
drowsiness 6.6%
withdrawal 6.6%
headaches 5.2%
constipation 2.6%
dizziness 2.6%
fatigue 2.6%
itching 2.6%
irritability 2.2%
sweating 2.2%

Reviews for Ultram

Commonly mentioned side effects
  • gen...
  • July 8, 2009

For Pain "I am 29 years old. I have fibromyalgia and hypermobility disorder. Without this drug, I would be worthless. I used to be a grumpy person that could not accomplish anything without major difficulty. I have taken Ultram ER 300 for the last 3 years. I have never been without this medicine for more than 12 hours. I am now 3 days off this medicine because I ran out by accident. This has been the most miserable experience of my life. I am on the verge of getting written up at work. I cannot focus. I feel horrible. I can't go to sleep at night, and I can't wake up in the morning. This is truly miserable. I feel as if I am being hit by a truck several times a day."

9 / 10
Was this helpful?YesNo
197 Report
  • jus...
  • December 31, 2015

For Chronic Pain "This medication is about as strong as aspirin or ibuprofen. If you take them longer than a few weeks, you will also end up with withdrawal worse than any other narcotic pain reliever. It can make you sick to your stomach, and if you're prescribed too much, it can cause severe seizures. If you've never been on any other opiate pain relievers, it may work for a bit, but I'd use extreme caution in doing so."

1 / 10
Was this helpful?YesNo
49 Report
  • Aar...
  • September 10, 2015

For Chronic Pain "It's a great alternative for people with stomach issues, as it causes no GI upset. You do have to eat, it can make you nauseous if you don't, but I can't tolerate antidepressants or strong opiates, so this does the trick for moderate chronic pain. Not a good choice for severe pain or post-surgery."

8 / 10
Was this helpful?YesNo
41 Report

Frequently asked questions

  • Ksa...
  • Taken for 1 to 6 months
  • March 24, 2017

For Pain "Took severe pain away. Hand and neck arthritis. Take with 2 Tylenol or ibuprofen every other dose for best relief. Brand name Ultram 50 mg every 5-6 hours if needed. For me, took most pain away! Better than Vicodin and not sure why, but so happy I have it. Cons: occasional nausea and big-time constipation-take with laxative or Colace. I started the pill slowly-two 25 mg per day over a period of a week and worked up to 50 3 times per day over 3 weeks."

9 / 10
Was this helpful?YesNo
34 Report
  • Anonymous
  • July 23, 2009

For Pain "This medication worked very well to ease my ankle pain. However, it left me feeling a little forgetful after taking it for a few days. It also made me very drowsy. But I was not in the severe pain that I had been. The most negative reaction was when I stopped taking the medication. The following day, I felt nauseous, shaky, dizzy, and had cold sweats. The withdrawal symptoms were very unpleasant."

7 / 10
Was this helpful?YesNo
45 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Maj...
  • July 9, 2015

For Pain "I just started this med yesterday for osteoarthritis and fibromyalgia. After reading the other comments, my experience is pretty normal. I'm itching like crazy, had a bad night-no rest, nausea, and mild headache. With all those side effects, it appears to have knocked off the edge of the pain. I will continue using it for a few days if I can handle the itching. I want to give it some time because I cannot use narcotics. I end up in the hospital with dehydration from vomiting when I use any narcotics."

7 / 10
Was this helpful?YesNo
34 Report
  • Car...
  • Taken for 1 to 6 months
  • December 31, 2012

For Pain "Personally, the medicine worked well for chronic pleurisy pain (bad stabbing sensation in side with flu or pneumonia), but I had horrible side effects. Dazed constantly, hallucinations, cold sweats, nausea."

3 / 10
Was this helpful?YesNo
42 Report

More FAQ

  • ktg...
  • September 13, 2010

For Pain "I have arthritis in most joints and back and neck pain. I have used Tramadol for 2 years now. It was life-changing in the way it relieved pain without the nasty side effects of hydrocodone (I got very irritable when it wore off). Seems to be taking a higher dosage for less relief but still would rather continue the Tramadol and use something for breakthrough pain on physical work days. If you experience nausea, try a lower dose and work up to more. Stick with it, the nausea went away for me. When I forget a day or so and go back to it, I sometimes get nausea again."

8 / 10
Was this helpful?YesNo
40 Report
  • Ind...
  • August 24, 2013

For Chronic Pain "I have been taking Tramadol for a while for endometriosis. It works okay. It makes me extremely restless, though, and after about 8 hours, I get really nauseated and end up vomiting. It does help with the pain, though. Not completely."

6 / 10
Was this helpful?YesNo
40 Report
  • Anonymous
  • November 17, 2009

For Pain "Aside from occasional nausea if I don't take it with food, I find it takes the edge off my lower back and arthritis pain. Causes some drowsiness, so I don't take it when I need to drive. Works better for pain than pretty much anything else I have tried."

9 / 10
Was this helpful?YesNo
27 Report
  • SL ...
  • October 12, 2010

For Pain "I was prescribed this medicine for moderate pain after surgery. My incisions bothered me, and I took 4 pills a day for the first 3 days, then usually 2 a day. However, the side effects: nausea, palpitations, dizziness, drowsiness and sleeplessness, constipation and mental vagueness were really too unpleasant to be rid of minor pain, so after a week I stopped taking it. It is annoying that after stopping it, I suffered nausea, palpitations, and weakness/drowsiness after large meals-possibly due to withdrawal."

3 / 10
Was this helpful?YesNo
26 Report
  • Anonymous
  • November 12, 2009

For Pain "I have been taking Ultram for three months now for a compressed lumbar disc. I have had no problems with it like I did with narcotic pain relievers (serious withdrawals when I did not need the medicine for pain). It does cause some drowsiness and once made me feel nauseated, but all in all I like this medication much more than any codeine-based painkiller."

8 / 10
Was this helpful?YesNo
28 Report
  • Ade...
  • Taken for less than 1 month
  • March 1, 2016

For Pain "I was on this medication briefly for my arthritis pain. I would describe it as 'many side effects, no good effects.' It had the side effects generally associated with narcotics (sleepiness, dizziness, nausea), but it didn't help my pain at all."

2 / 10
Was this helpful?YesNo
20 Report
  • KCj...
  • October 3, 2009

For Pain "Took first dose of Ultram and started having severe nausea. Recovered after 36 hours. Unsure that it caused the nausea since I had a flu shot that day. I tried it again two weeks later and again experienced severe nausea, which ended again after about 36 hours."

1 / 10
Was this helpful?YesNo
19 Report
  • Anonymous
  • October 6, 2009

For Pain "I was prescribed Ultram/tramadol for the daily pain I am in due to being crushed from the waist down. I only use it when Tylenol or ibuprofen will not work, which is maybe once a week or a handful of times per month. Ultram does help take the edge off the pain most of the time, but on occasion, just doesn't help. I need to be sure I have food in my stomach before taking it, or it will make me pretty nauseous. It also keeps me up at night if I take it late in the day. I haven't had any issues concerning withdrawal from it, but it may be because I do not use it on a daily basis, but only when needed."

6 / 10
Was this helpful?YesNo
21 Report
  • Anonymous
  • February 24, 2009

For Pain "I was prescribed this medication for chronic severe neck pain. I was taking 50 mg per day. While it worked to eliminate pain, I experienced constant nausea, vomiting, light-headedness, and many symptoms of serotonin syndrome since I also take Celexa each day. Serotonin syndrome is serious and dangerous and can increase the likelihood of seizures. Also, I'm taking this medication at night, and it keeps me awake all night instead of allowing a good night's rest."

6 / 10
Was this helpful?YesNo
18 Report
  • Les...
  • May 4, 2009

For Fibromyalgia "Ultram was helpful for my muscle pain associated with fibromyalgia. It did not make me feel 'dopey' or 'high' or more tired, etc. However, I would have to eat a substantial meal before taking it and then eat an apple or something after I took it, or I feel on the verge of vomiting. It made me so nauseated if my stomach was not completely full."

7 / 10
Was this helpful?YesNo
19 Report
  • Sky...
  • August 27, 2009

For Pain "I take 100 mg 'as needed' for chronic neck and shoulder pain after dual AFDC surgery, which left me with some major nerve damage. It doesn't totally relieve my pain, but it makes it tolerable. One dose makes me nauseous with or without food in my stomach. If I have a bad neck day and take 2 doses, I will spend the night throwing up, so I never take 2 doses anymore."

4 / 10
Was this helpful?YesNo
18 Report
  • Anonymous
  • December 25, 2010

For Pain "I was prescribed tramadol for a severe sore throat. I couldn't eat anything or take my other medicines before taking it and was only able to drink enough to keep me hydrated. Although I have experienced headaches and nausea since taking it, I can at least eat soft foods and soup and take my other medications. The headaches and nausea aren't pleasant, but, after losing 6 lbs in 2 days because I couldn't eat, the benefits definitely outweighed the side effects."

8 / 10
Was this helpful?YesNo
17 Report
  • Anonymous
  • October 24, 2011

For Back Pain "It works better than any narcotic for my neck/back pain, without the side effects of narcotics, such as nausea and tiredness."

10 / 10
Was this helpful?YesNo
95 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.