Zepbound User Reviews & Ratings

• Anonymous
• Taken for 1 to 6 months
• March 19, 2024

For Weight Loss (Obesity/Overweight) "This medication works beyond all my expectations!! I am a 40-year-old female and was at a starting weight of 226 when I began the 2.5 mg dose. Immediately, I noticed I could not finish more than a few bites of food, and the thought of chewing meat was repulsive. But for some reason, I could eat fish and fresh fruit. The mental food noise is gone. It's so nice to go grocery shopping and not look twice at foods that, in the past, I could easily binge eat. Now everything has side effects, so I will say they are manageable. My doctor gave me a script for Zofran for the nausea, and that helps tremendously. For constipation, I take Senna, and at times when it was really bad, I used a pediatric suppository (Pedia-Lax), peppermints for sulfur burps! Don't eat too much, this med delays stomach emptying, so eat slowly and in small portions. I only drink water and want water!! I have so much energy! I have lost 27 pounds in 6 weeks. I am on 7.5 mg and can't wait to reach my goal!"

• Fra...
• Taken for 1 to 6 months
• February 8, 2025

For Weight Loss (Obesity/Overweight) "I have been on the lowest dosage of Zepbound for about 3-4 months. I’ve lost 22-25 pounds. No, I haven’t increased the time spent exercising. But I am no longer hungry and stuffing junk food into my mouth. My tongue hasn’t forgotten it loves Snickers, but I am able to grab apples and be content. My nephrologist put me on it as I do have kidney disease, I was in the obese range, and I was prediabetic. It’s expensive ($400 per month), but I feel better about myself, and so it’s worth it to me. I was the fat kid in my family and have never been a thin and beautiful person. But Zepbound has given me higher self-esteem because it’s doing what it’s supposed to do… help me to shed weight in a healthy way. I do sometimes experience constipation, then a giant diarrhea round, but I feel good most of the time. I have no other side effects and have been pleased with the assistance Zepbound has given me. Thank you, Lilly Pharma!"

• Mar...
• Taken for 1 to 6 months
• June 29, 2024

For Weight Loss (Obesity/Overweight) "Update on my review from May 25, 2024. I have now been on Zepbound for 16 weeks. Current dosage 10 mg. In these 16 weeks, I have lost 40 pounds, from 204 lb to 164 lb, and my waist size has gone from 40 inches to 36 inches. For context, I am 5'10' tall. Even more incredibly, my blood pressure has decreased from 195/90 to an average of 116/60 as of today. I have more energy and am running regularly 5 days per week. I am also sleeping better, which I think comes from a lessening of sleep apnea symptoms. The only remarkable side effect has been occasional constipation, which is relieved by Miralax. With not only weight loss but improvement in other health measures, I consider my Zepbound treatment to be quite successful!"

• Ree...
• Taken for 1 to 6 months
• March 15, 2024

For Weight Loss (Obesity/Overweight) "Was on Wegovy 2 months (PsA weight loss need) - horrible. Lost 18 pounds but got depression, which is odd for me as I have never had it. Once off it, about 3 weeks, I was fine. Decided to give ZepBound a try, a friend had great success with Monjouro (diabetic), when this came out, I was approved. Having a friend with experience really helped to get me through the first 3 weeks. They were rough. But I knew to stay away from meats for 5 days after shot and ANYTHING with fat or oil - it will not digest. 2 days after the shot are the hardest as far as digestion, eat very small, eat early or reflux will occur. My 'go to' is a cup of mac & cheese, half a bagel (plain) or berries (apples indigestible). No variety for me on this. Menthol cough drop a lifesaver - soothes my stomach. Sugars OK. Diarrhea from some foods, turned to some constipation after 2 months. Lost 27 pounds in 3 months, the fatigue is my worst side effect. Find your digestible foods, stick with them, exclusively."

• Ann...
• Taken for less than 1 month
• January 9, 2024

For Weight Loss (Obesity/Overweight) "In the last 7 months, I went on a medically supervised, 1100-calorie per day diet to lose weight. I'm a 52-year-old female, 5'9'', and weighed 282 lbs. I managed to get down to 255 lbs and was feeling physically better, but constantly hungry, cranky, and miserable (also miserable to be around). After much discussion with my doctor (who was in favor of the medication), I started taking 2.5mg of Zep just before Christmas. After 3 weeks of use and despite many holiday celebrations, I'm down 4 lbs and all my cranky hanger is gone. I feel much better - all the noise in my head about food has disappeared, along with much of my appetite. I had constipation for the first couple of days after the first shot, but now I don't have any. My side effects have been minimal thus far, but I notice cravings and a bit of hunger coming back on days 5 and 6. I'm amazed at how easy this makes managing my diet, and it is so nice to not feel like a failure for once! I'm paying out of pocket with the savings card, but the $560 per month is so worth it."

• Sus...
• Taken for 1 to 6 months
• March 26, 2024

For Weight Loss (Obesity/Overweight) "I've been on Zepbound for about 3 months. I'm 5'3' and started at 167. So far I have lost 12 lbs. trying to maintain a 1,200 calorie diet. The main thing is to watch what you eat and quit when you are full. The only side effects I've seen are fatigue and constipation. The shots don't bother me at all and no nausea, thank goodness. The only thing I'm really worried about is gaining it back when I stop. Good luck to all!"

• Mik...
• Taken for 1 to 6 months
• January 15, 2024

For Weight Loss (Obesity/Overweight) "I’m a 6’4", 275-pound male, 62 years old - no diabetes or health issues, on no other meds. Obtained prescription via Dr. and took the first 2.5 mg injection on Dec. 24. Lost 10 pounds with the first 3 shots, then Dr. said I could go to 5 mg (saved the last 2.5 mg pen for future use) because weight loss had stopped. After starting 5 mg, lost 2 pounds in 2 days - so combined weight loss using 2.5/5 mg is now at 12 pounds in six weeks! No significant or terrible side effects except some constipation, intermittent fatigue, and minor chills at times (not a lot - could just be the cold weather). I've yo-yoed up and down with weight for years. Because of my size, I can eat a lot of food - but this drug has significantly reduced my appetite, and I have more energy overall. I can’t wait to see the results in a few more months. Zepbound has so far been perfect for me. I don’t mind the $550 price (with the Lilly savings card - has been hard to get CVS to make it work, but that’s another story/nightmare)."

• bae...
• Taken for 1 to 6 months
• March 18, 2024

For Weight Loss (Obesity/Overweight) "Absolutely life-changing. For the first time in my life, I'm satisfied by reasonable portions. I'm not always thinking about the next thing that I'll be eating. I'm able to feel and respond to my actual hunger cues without my scarcity brain taking over. Even if I wasn't losing weight, the relief of food obsession and binge eating disorder would be worth it. Four weeks in, down 13 lbs and very satisfied. Only side effect has been feeling cold and some mild constipation."

• Anonymous
• Taken for 1 to 6 months
• February 26, 2024

For Weight Loss (Obesity/Overweight) "So far, so good. Rarely get hungry and can't eat too much. Side effects: Heartburn, reflux, constipation, hair loss. I will have to weigh myself in the morning, but I am guessing I am down about 8 lbs. in 5 weeks. Just started on the 5 ml. No exercise yet. Wine and alcohol will definitely slow down the progress. Not a lot of cravings for junk. Every now and then I want something fried, but it will have you on the crapper by the next morning! Stay away from greasy food on this! And YES, the needle DOES hurt to me!"

• Can...
• Taken for 1 to 6 months
• April 18, 2024

For Weight Loss (Obesity/Overweight) "I am in my 50s and I stayed on the 2.5 for 2 months and just began the 5 mg today. I had gastric sleeve exactly a year before covid, lucky me, huh? Working from home, no gym, already had depression, joint, and severe back issues. It all did not mix with slowing down and sitting down. I gained half of the weight I lost, and the high cholesterol returned. I started Zepbound on Feb 17, 2024, and lost 18 lbs by my first check-up on April 1. Very fast. My cholesterol dropped significantly. I do not have high blood pressure, but it was down too. All blood work is great. The only side effect is constipation that I fixed with Miralax. There are no food cravings or noise in my head. I get full very fast, although I have to remind myself to eat. I have dry mouth, I bought sugar-free popsicles to deal with that. I have been sleeping better, although I stay up late due to the energy it gives me."

• dem...
• Taken for 1 to 6 months
• April 28, 2025

For Weight Loss (Obesity/Overweight) "Does everything it says. I love it, the only side effect I have is extreme constipation. I've been taking it for about 5 months and down 46 lbs, and I feel much better. I have chronic pain in my lower back, but with weight loss, it helps a little."

• JWa...
• Taken for 1 to 6 months
• March 28, 2025

For Weight Loss (Obesity/Overweight) "Zepbound was effective within the first week. I experienced a significant decrease in hunger and decreased interest in food. I also found that I could not always finish a meal serving in one sitting. Initially, I had minor issues in bowel habits (constipation and diarrhea). Both symptoms are minor and managed with adequate hydration and fiber-rich foods. More disconcerting have been the “egg burps” caused by bacterial action on sulfur-rich foods in a slowed GI system. I have selected less sulfur-rich foods and make a concerted effort to drink more water during a day or two following the weekly injection. This side effect seems to have moderated, perhaps as I am into the second month of my current dosage and third month on Zepbound and/or temporarily minimizing sulfurous food intake in a short period following injection. I also track my food intake and assure I am eating an adequate level of protein. I have lost 15 pounds in 10 weeks. I am 77 and a woman."

• Dee...
• Taken for 1 to 6 months
• April 6, 2025

For Weight Loss (Obesity/Overweight) "I started in January and have moved doses up monthly. This morning I took my 4th 7.5 mg dose. I did have a 2.5 mg pen malfunction and moved up to 5 a week early. I've been losing 1-3 pounds a week, for a total today of 28 lb loss. My goal is to lose 50. As far as side effects, they really aren't too bad for me. Daily Colace helps any constipation, which has not been much of an issue anyway. Occasional nausea is fleeting and is helped with Coke One. I know some are against drinking soda, but Coke One does not have sugar and has been my nausea cure for as long as it's been on the market. My appetite is diminished, but not gone. I've changed my eating pattern to several small, healthy mini-meals during the day instead of 3 'regular' meals. Zero cravings for junk food or much snacking at all. Part, I'm sure, is that I'm keeping those mini meals full of protein and vegetables. The only real issue that I've had is fatigue. It hits about an hour after the shot and lasts about 36 h."

• Sus...
• Taken for 1 to 6 months
• October 19, 2024

For Weight Loss (Obesity/Overweight) "Been taking Zepbound 2.5 mg for four weeks - just had my fifth injection last night. Started at 254 lbs. and have lost 18 lbs!! My last weigh-in was 236 lbs.! The only annoying side effect I had was mild constipation. I had no idea what food noise was until it was gone. Wow. Finally understand what it is to be normal. Not sure what my goal weight will be yet, somewhere between 175-150 lbs. I'm in my early 50s and finally confident I'll have sustainable weight loss."

• NJ-...
• Taken for 1 to 6 months
• January 23, 2025

For Weight Loss (Obesity/Overweight) "I've finished my 5th month of Zepbound injections. The dose pen makes the injection simple and painless. It took me a few weeks to actually feel that this was changing my appetite or cravings, but once it did, I have no problem resisting the habitual munching. Although my diet changes have helped the amount of food I eat at one time, I don't get the full feeling that a lot of people talk about. So I have to know when to push away from the servings. This was prescribed for weight loss, but I do have sleep apnea as well. I've lost 20 lbs, which matches the estimated 1 lb per week under this med. My goal weight is a 40 lb reduction. The only side effects that I've noticed are primarily increased gas and constipation if I don't push the fluids. So far, it's been a positive experience and I look forward to added results."

• Mar...
• Taken for 1 to 6 months
• May 25, 2024

For Weight Loss (Obesity/Overweight) "Started using Zepbound in March 2024, at 2.5 mg. History of Obesity (BMI > 29) and Hypertension. Starting weight was 202 lb. and Blood Pressure Avg. of 153/90. As of today, May 24, 2024, currently on 10mg. My weight is currently 177 lb, having lost 25 lbs (12%) of starting weight. It was easy to learn how to use the injection pen, and it is a painless process. I am also exercising, running 4-5 days per week and weight training 2 days per week. Exercise is an important adjunct to weight loss treatment, and can help maintain muscle mass while losing weight. It is also imperative to eat foods rich in protein and green, leafy vegetables. Side effects have been minimal, with occasional constipation, which is remedied by using Miralax or similar products."

• Ano...
• Taken for less than 1 month
• April 26, 2025

For Weight Loss (Obesity/Overweight) "I am on my 5th week. Just started 5 mg Friday 04/25/25. I started 03/28/25 on the 2.5 mg. My second day I was nauseous, but nothing Sprite and Zofran couldn’t fix. Fast forward to today. I have been sleeping really well, inflammation is gone, my hunger and food noise is gone. Now I notice the day before my shot day I start to crave some, but I just drink my water to stay full. Also, a little minor constipation. I take a stool softener with my morning vitamins, which helps, plus water, water, water!! I am loving this medicine so far, I am down 10 lbs, which I don’t think that’s bad in 5 weeks."

• cli...
• Taken for 1 to 6 months
• July 31, 2024

For Weight Loss (Obesity/Overweight) "I asked my doctor about starting Wegovy since my efforts weren't working, but she recommended Zepbound - and I am so glad she did! My appetite is no longer controlling me, and yet those pre-diabetic low blood sugar drops are gone. After 3 months at the 5 mg dose, I'm still consistently losing about 1% of my weight each week. The only side effects are minor constipation and heartburn, but they encourage me to drink more water. I was hesitant to start because...needles...but it's so tiny I don't feel it at all. I wish I had started sooner!"

• Anonymous
• Taken for 1 to 6 months
• February 16, 2025

For Weight Loss (Obesity/Overweight) "My side effects are constipation, headaches, vision is foggy, insomnia, stomach pain, nervousness, dehydration, frequent urination, bumps on my labia. It is very easy to use. I have lost 14 pounds in two months. It does cut your hunger."

• KCP...
• Taken for 1 to 6 months
• August 30, 2024

For Weight Loss (Obesity/Overweight) "Life-changing. Down 30 pounds in 5 months. Within a few hours of the first dose, I experienced hunger suppression, increased satiety, and best of all, reduced food noise. I thought about food 24/7 before taking this medication. Despite tracking calories and eating whole foods and eliminating most sugar, I always craved sweet and high-fat foods like ice cream and felt hungry even after a meal. On this medication, I crave veggies and fruit and protein. Side effects: as a woman going through menopause, the hot flashes have been miserable. I also have always had an extreme heat intolerance for hot weather. On this medication, hot flashes are gone and I've enjoyed summer for the first time in my life. Negative side effect: constipation. Easily manageable with Miralax and Benefiber."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• Myk...
• Taken for 1 to 6 months
• December 20, 2024

For Weight Loss (Obesity/Overweight) "Have lost approximately 25 lbs in about 4.5 months. No major side effects. Occasional constipation, but I'm taking fiber supplement gummies, which help with regularity. Taking 7.5 mg dosage at present. Will increase to 10 mg next refill. I feel full for longer periods, which has helped control hunger bingeing. My goal would be to drop another 25-30 lbs. Still looking to start an exercise routine, which I can commit to, but life's demands interrupt my progress. I'm very grateful for this medicine."

• Lis...
• Taken for 6 months to 1 year
• March 29, 2025

For Weight Loss (Obesity/Overweight) "Best method for weight loss and keeping the weight off. I've lost over 100 lbs and am finally comfortable in my skin again. When you change mg dosage, fatigue could be concerning, and it does happen. Working out helps, making sure you stay hydrated, and working out was the biggest help for me. I did have constipation, and it was managed. I did have hair thinning and started taking Nutrafol. I've struggled with my weight my entire life. Not anymore. I wish we could add photos, but we can't. Portion food sizes of what you can eat are minimized. The sugar cravings were gone. Not only did those cravings disappear, but so did the cravings for food that your body turns to sugar. For example, I haven't eaten a potato chip in over 7 months. No desire for breads, mayo, Miracle Whip, and numerous other things. I FEEL so much better. It is costly, but so is poor health and obesity. I wish big pharma would realize how many Americans struggle with obesity and cover this through insurance."

• chu...
• Taken for 1 to 6 months
• June 1, 2024

For Weight Loss (Obesity/Overweight) "5’ 8” and 272 was my starting stats. I did four weeks of 2.5 then went up to 5.0. I am only on my 6th week (4 2.5s and 2 5.0s) and I have already lost 30 pounds. Now, at 242, I am looking to take off another 30-50 pounds. I am trying to be put on a list to have a transplant and have to lose a certain amount of weight to make the list. I give the medication a 100% A+. If you need to drop weight, this is a great medication. Side effects: Constipation. Drink as much water as you can and be prepared to take laxatives to poo. I’m talking rock pebbles harder than pleasing a Gold-digger on a date, you’ll definitely have to take some laxatives to poo. I suggest flavoring your water. It helps. Candy: You will crave sugary candy like Gobstoppers, Sour Patch Kids, Skittles, pretty much anything you can get your hands on. Try dark chocolate almonds and just small nibbles of candy when you get really, really sleepy. Bottom line: It works! It's worth the hard rock poo."

• fat...
• Taken for 1 to 6 months
• June 16, 2024

For Weight Loss (Obesity/Overweight) "Just under 5 months. Down 36 pounds from size 16 to a 12/14. Almost 50. 5'9'. F. Started at 2.5, of course. Currently on 10mg. The biggest issue for me has been finding the medication in stock. It makes me not think of food until I'm hungry and then I eat a little something. I stay full a long time. I can only assume this is what normal people without food issues are like. I have lost upwards of 100 pounds with very hard work over a period of 2-4 years at two different times in my life. I need help this time around. Even when I was doing well with diet and exercise prior to this medication being available, all I did is think about how many calories I had eaten and how many I had left. I don't even count calories now. I have almost no interest in eating. The day before my injection is due, I am more hungry but still not eating more than 1800c. No real side effects aside from constipation in the beginning. It's amazing."