Skip to main content

Zepbound User Reviews & Ratings (Page 4)

Zepbound has an average rating of 8.8 out of 10 from a total of 404 reviews on Drugs.com. 83% of reviewers reported a positive experience, while 1% reported a negative experience.

Reviews for Zepbound

Commonly mentioned side effects
  • Anonymous
  • Taken for 6 months to 1 year
  • March 4, 2025

For Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."

7 / 10
Was this helpful?YesNo
1 Report
  • Suz...
  • Taken for 6 months to 1 year
  • February 26, 2025

For Weight Loss (Obesity/Overweight) "I began my weight loss journey in late January 2024. Over the next 12 months, I lost 40 pounds. However, I've hit a plateau for the past four months, since the end of November 2024, and it's now February 25, 2025. I still need to lose at least another 40 pounds. Zepbound has been a significant help in my journey. My clothes fit much better, and I've gone from a size XXL to a medium. In addition to Zepbound, I also strength train, maintain a healthy diet, and track my calorie intake. The only side effects I've experienced with Zepbound are occasional acid reflux, mild nausea, and some constipation. Currently, I am on 12.5 mg, but my doctor has decided to update my dosage to the 15 mg to see how I do on that dosage. Hopefully, it will kick me over the plateau and I will end up losing the next 40 pounds that I need to. Other than that, I love Zepbound. I think it’s great."

9 / 10
Was this helpful?YesNo
1 Report
  • Hai...
  • Taken for 1 to 6 months
  • December 6, 2024

For Weight Loss (Obesity/Overweight) "The first couple of weeks, I was nauseous throughout the day. I had a hard time eating more than a couple of bites and didn't want to drink anything. Then I made myself eat a very light breakfast, protein drinks for lunch, a small portion of food for supper. Drinking a bottle of water with each meal and an extra one in the evening. Now on my 11th weekend, all's well. Oh, and I had to give up caffeinated coffee, it was contributing to my nausea in the first two weeks. Started at 239 lbs, 5'9'', 69 yrs. old. Now at 210.4 lbs."

9 / 10
Was this helpful?YesNo
1 Report

Frequently asked questions

  • Use...
  • Taken for 6 months to 1 year
  • March 5, 2025

For Weight Loss (Obesity/Overweight) "I have been using weekly Zepbound shots since July 23rd, 2025…6-7 months. I have lost 47 lbs., which is 23% of my body weight. I have had occasional waves of nausea, but not so bad that it made me want to quit. My sleep has been disrupted some nights when I can’t go back to sleep after waking up. I’m currently up to 7.5 mg. And I’ve started taking the shots every 10 days instead of 7 days so I can gradually wean myself off of it. I have about 5 lbs. to go to meet my personal goal and about 10 lbs. to be off of the “overweight” BMI chart. I have been seeing my doctor every 3 months for bloodwork and check-ups. I am happy that I decided to try Z, and I’m also pleased that my insurance company paid for all of it except for $25 a month. Totally worth it."

9 / 10
Was this helpful?YesNo
0 Report
  • Ano...
  • Taken for 1 to 6 months
  • July 17, 2025

For Weight Loss (Obesity/Overweight) "I have lost 20 lbs in 3 1/2 months on Zepbound taking 2.5, 5.0, and 7.5 mg so far as per plan and dosage increases. I plan to use 5 mg for maintenance dosage now that I am almost at my goal weight. It is very simple to use. I had some GERD, nausea, and adjustments to make with certain foods, but that subsided after the first few months. You definitely cannot overeat as you will not feel well. The exhaustion and body aches are what bother me the most. For the first 3 days after an injection, I am so tired that it impacts what I can get done in a day, including energy to exercise and do my job during the day. I am sleeping okay with it, but the fatigue is almost debilitating."

8 / 10
Was this helpful?YesNo
1 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Ano...
  • Taken for 1 to 6 months
  • June 19, 2025

For Weight Loss (Obesity/Overweight) "I am up to a 12.5 dose, almost 4 months on Zepbound. I have only lost 11 lbs. I am on a calorie-restricted diet, 1400 cal per day. I don’t feel a lot of hunger and my cravings are not many. I am disappointed in the loss rate, but if it keeps me from gaining back the weight, I’ll be happy. My only side effects have been constipation and minor nausea."

6 / 10
Was this helpful?YesNo
0 Report
  • Kel...
  • Taken for less than 1 month
  • July 8, 2025

For Weight Loss (Obesity/Overweight) "I just started my 1st shot Mon July 7th 2025. I'm 39 and weigh 231 lbs. Throughout the day, I was fine and eating regularly as usual, but the next morning... OMG! The nausea is horrible, but that won't stop me from losing the 40 lbs I'd like to lose. Drink lots of water, listen to your body, and get plenty of rest."

8 / 10
Was this helpful?YesNo
0 Report

More FAQ

  • Ano...
  • Taken for 1 to 6 months
  • June 22, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound five weeks ago. I started with 2.5. My first couple of weeks were fine, but by my third week after that shot, I could not eat for 3 days. I tried even sipping on water and couldn't because of the nausea. My throat kind of burnt all the way down to my stomach, it felt like someone was squeezing the top of my throat. I just took my first shot of the 5.0 3 days ago, and I still haven't been able to eat because I'm so nauseous, and again my stomach's hurting. I tried yesterday to take some Rolaids, but that made me throw up. I haven't told my doctor, and I'm still going to continue taking it, but if this keeps up, it's not worth it. But I will continue to try maybe one or two more weeks, but if it just keeps up and is this miserable, I'm going to stop taking it. Hopefully, no one else has this feeling. But I didn't lose 19 lb in one month. I hope everyone does better on it than I am."

8 / 10
Was this helpful?YesNo
0 Report
  • Mor...
  • Taken for less than 1 month
  • July 21, 2025

For Weight Loss (Obesity/Overweight) "So far, so good. I am suffering from the nauseated feeling, burping, fatigue, and muscle cramps. I'm at 2.5 level, week 3. I'm definitely eating a lot less."

10 / 10
Was this helpful?YesNo
1 Report
  • Sus...
  • Taken for 1 to 6 months
  • April 7, 2024

For Weight Loss (Obesity/Overweight) "Nausea and constipation. I started on 2/22/2024 at 207 pounds, and now on 4/7/2024, I weigh 180 pounds."

8 / 10
Was this helpful?YesNo
22 Report
  • Suz...
  • Taken for 1 to 6 months
  • January 23, 2025

For Weight Loss (Obesity/Overweight) "Encounter burping, nausea, and can’t fall asleep easily."

5 / 10
Was this helpful?YesNo
8 Report
  • Ano...
  • Taken for less than 1 month
  • May 14, 2025

For Weight Loss (Obesity/Overweight) "I have lost 14 lbs in 4 weeks. Extreme fatigue and a little nausea. A little shortness of breath when walking. Feeling weak."

7 / 10
Was this helpful?YesNo
3 Report
  • Cry...
  • Taken for 6 months to 1 year
  • February 21, 2025

For Weight Loss (Obesity/Overweight) "I've lost 67 lbs in 10 months. Only side effects have been some constipation and slight nausea. This has been a life changer for sure!"

9 / 10
Was this helpful?YesNo
4 Report
  • Den...
  • Taken for less than 1 month
  • July 14, 2024

For Weight Loss (Obesity/Overweight) "Works for weight loss if you can tolerate it. I went to the ER with nausea, vomiting, severe depression, and anxiety. Won't be continuing."

6 / 10
Was this helpful?YesNo
7 Report
  • Vio...
  • Taken for 1 to 6 months
  • November 24, 2024

For Weight Loss (Obesity/Overweight) "For the most part, my biggest side effect has been burping and nausea. Even before using this medication, I had bouts of reflux."

8 / 10
Was this helpful?YesNo
2 Report
  • Ano...
  • Taken for less than 1 month
  • May 27, 2025

For Weight Loss (Obesity/Overweight) "Just got started, currently in my 3rd week. Moderate to severe diarrhea started after the 3rd shot. No nausea at this point. Some stomach pain."

5 / 10
Was this helpful?YesNo
0 Report
  • Suz...
  • Taken for 6 months to 1 year
  • April 14, 2025

For Weight Loss (Obesity/Overweight) "Having great success with weight loss but having trouble with nausea and vomiting."

8 / 10
Was this helpful?YesNo
0 Report
  • San...
  • Taken for 1 to 6 months
  • July 2, 2024

For Weight Loss (Obesity/Overweight) "Had just a little nausea. Love the ease of the shot. Weight loss is great."

9 / 10
Was this helpful?YesNo
0 Report

See also:

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.