Zepbound User Reviews & Ratings (Page 3)

• Anonymous
• Taken for less than 1 month
• November 29, 2024

For Weight Loss (Obesity/Overweight) "First dose 2.5 today, and already my appetite is none. I only ate a very small portion plate and drank nothing but water. It wasn't until I tried to have my daily cup of coffee when I felt very nauseated after only a few steps. Day 1, and I'm here to say I know it's going to work out (I'm hoping I can build my coffee/frappe tolerance back up, I LOVE my coffee)."

• 2go...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "On week 5 of Zep. Goal to lose 20-25 lbs. Received a 2.5 mg 'loading' dose, I split it into 1.25 doses 3 days apart for the first 2 weeks as I tend to react strongly to meds. I had a bit of anxiety and fatigue on this dose and appetite suppression that waned by week 2, so I increased to 2.5 in one shot for weeks 3 and 4. Less anxiety/fatigue but more nausea and constipation, still manageable. I received a 5 mg dose in the mail at week 4 but had already lost 15 lbs on the 2.5 dose for 4 weeks. Week 5 - I tried the 5 mg. The next day, I was so sick to my stomach and nauseous that I struggled to eat or drink at all. I was dizzy and felt terrible, depressed, and kept getting the long bouts of hiccups. I will be at goal soon and plan to switch to metformin to maintain weight. For me, this med is miraculous, but I do not feel great on it. (For reference - I have a mental health diagnosis and pre-existing mild gastrointestinal issues, MTHFR gene variant)"

• wen...
• Taken for 1 to 6 months
• March 26, 2025

For Weight Loss (Obesity/Overweight) "I have only taken it for 5 weeks. I have had a lot of nausea and acid reflux. Hopefully, they go away, but when I started, I weighed 174, and 5 weeks later, I am at 165, so it's working. Side effects seem to be decreasing, so I'll keep going for now."

• Mom...
• Taken for 1 to 6 months
• November 19, 2024

For Weight Loss (Obesity/Overweight) "I have had great success with Zepbound, currently on 15 mg. Been on it for 6 months, 67 lbs down. Went from a size 20 pants to a 12. I have had some nausea and vomiting. It’s easy to use. I’m squeamish when it comes to shots, so for the first 2 months, my husband had to inject me. I got used to it and can now do it on my own. I feel so much better about myself and so much healthier."

• get...
• Taken for 1 to 6 months
• June 4, 2024

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost 3 months now. I've been at 2.5 the whole time as we are struggling to get any higher doses from back order. I have lost over 20 pounds already. My first shot, my side effects weren't horrible, but I also deal with nausea daily. I also had really bad pain in my upper back, neck, and shoulders like I had whiplash, but that was gone after 48 hours and was nowhere near as bad the 2nd shot. And then nothing after that. This past week though, I've been waking up starving, like I haven't eaten in days. I normally eat dinner around 5:30ish and have a small snack around 8ish, and I haven't had this before. The only other thing I've noticed and just read it could be a side effect is my hands have been super itchy, like I'm having an allergic reaction to something, which I've been thinking that's what's going on. But overall, my side effects have been very minimal, and the benefits majorly outweigh them."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

For Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Cap...
• Taken for 1 to 6 months
• August 4, 2025

For Weight Loss (Obesity/Overweight) "I am in the middle of my second month of 5 mg doses, after a month with 2.5 mg doses, and will go to 7.5 mg after done with this monthly 5 mg dose. I am an 81-year-old male, 5’7”. I started at a weight of 226.6 lbs the first week in May 2025. My current weight is 205.6! And my blood pressure, with the same blood pressure medication dose, is now consistently normal, in the under 220 over low 70s! Amazing. No side effects other than slight nausea. Eating moderately and eating healthy foods. Working out at the gym 3-4 times a week. Hydrating vigorously and taking over-the-counter Miralax to prevent constipation. No insurance help. Acquiring Zepbound through LilyDirect. I am retired, and the cost is a real hardship for me."

• KJa...
• Taken for 1 to 6 months
• December 27, 2024

For Weight Loss (Obesity/Overweight) "Fantastic! I have never felt better! Lost 14 lbs in 1 1/2 months minimal side effects a little nausea here and there. Nothing crazy, truly a miracle drug for weight loss, the bonus is inflammation in general is better, and I am hoping to get off my BP meds soon!"

• Lyn...
• Taken for 1 to 6 months
• December 20, 2024

For Weight Loss (Obesity/Overweight) "I am happy with the results so far. I have lost 29 lbs in 13 weeks. My goal is 75 lb weight loss. My appetite is far less, and my cravings for sugar have much improved. I have had some constipation and 1 or 2 episodes of nausea but did not vomit. You have to drink water! I started on 2.5 mg and was increased to 5 mg. I'm worried to go to a higher dose due to potential increased side effects, as I have a history of kidney issues. However, since I started the medicine, my Hga1c is normal and lipid panel perfect."

• kel...
• Taken for 1 to 6 months
• March 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 45-year-old female starting weight 243... I just took my fifth shot a few minutes ago, and I have lost a total of 26 lb since my first shot. Food noise is completely gone, and I find myself not able to eat anything until the day before my shot. I do drink a lot of water and have no cravings for sweets like I used to. I have done moderate exercise in the evening and tried to force myself to eat some source of protein throughout the day. I also take women's one-a-day gummies and I feel fantastic! The very first shot I took, the first few days I felt horrible, like I had the flu and had been hit by a bus. Since then, no side effects except for very mild nausea, which I take promethazine to help, and it does wonders. My sleeping patterns have gotten better, and my energy has increased. It states for my age and height at 5'9, I should weigh 167. I honestly feel like I would look very sickly if I got that small, so my goal is basically just to fit in my pants from last summer, lol."

• 123...
• Taken for 1 to 6 months
• September 16, 2024

For Weight Loss (Obesity/Overweight) "I began this treatment in April. It is now mid-September. I have lost 20 pounds. It is very easy to use, which is a big deal for those who have a needle phobia. In the beginning, I had very few side effects. After going to the 7.5 mg dose, I started to experience constipation and nausea. To combat this, I began a small fiber intake routine and requested Zofran from my doctor. Both are very effective for those side effects. I am now on a 12.5 mg dose and doing well. I feel I am close to a maintenance dose. This medication was quite effective. I am a small person, menopausal, and struggled with losing weight. Losing 20 lbs for my size is a very big deal. Through this process, I have learned better eating habits, keeping my portions small to maintain a healthy weight and continuing my exercise routine even if I am not losing weight. All in all, this was a win-win for me."

• Anonymous
• Taken for 6 months to 1 year
• March 4, 2025

For Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."

• Pau...
• April 23, 2024

For Weight Loss (Obesity/Overweight) "I am a 72-year-old female, 5'7", and 204 lbs. I started Zepbound 3 weeks ago. I don't have the nausea, diarrhea, and other ailments that I've read about, but I've had a problem with itching. From the top of my thighs, up my back and my front and my arms all itch a lot. My doctor told me to quit the injections for 3 weeks to see if it helped. For the first time, I didn't do what he recommended because at this point, I've lost 7 lbs and I'm very happy about that. Hopefully the itching will die down with time. I'm very optimistic about my success and I will continue. It's only costing me $245 a month which is very doable. Taking Benadryl and using cortisone cream seems to help."

• Anonymous
• Taken for 1 to 6 months
• January 20, 2025

For Weight Loss (Obesity/Overweight) "I am a 48-year-old female and have been on this for 6 weeks. I am down 9.2 lbs and haven't had a lot of side effects. With the dose increase to 5 mg, I noticed intermittent nausea, but nothing that prevents me from daily tasks or from taking the next shot. I am rarely hungry and get full very quickly. The shot doesn't really hurt, but I do bruise at the site. Weight loss isn't super fast, which is good because I don't want to have a lot of loose skin."

• Hed...
• Taken for 1 to 2 years
• July 15, 2025

For Weight Loss (Obesity/Overweight) "I love Zepbound as it is the only thing that has helped me lose weight easily. After reading the reviews on here, my approach has been somewhat different as I refused to give up any foods or alcohol as that isn't real life for me. I walk 4 miles a day but haven't done real cardio or weight lifting very often so that is next. I have been on it for 13 months and started at 190 and am at 152, which is less than my high school weight/5'6'' and was a college athlete, so a very muscular type build. I am ecstatic at this weight but scared to go off Zepbound as I can control my food addictions with it and don't eat 2000 calories at midnight anymore. I get full very quickly so I am eating way less than my old norm of 4000 calories a day. :-) I am at 12.5 mg and the side effects I have had are mostly fatigue and my hair breaking off. At first, I had nausea and injection site swelling, but that went away after the first month."

• San...
• Taken for 1 to 6 months
• May 2, 2024

For Weight Loss (Obesity/Overweight) "I am African American, age 54, weight 225 lbs. I started Zepbound a month ago after previously trying to lose weight with Wegovy in 2023 but ran into demand issues with Wegovy. Wegovy also gave me extreme nausea and vomiting but amazing weight loss results. Zepbound's needles leave bruises, and I get tension headaches on the 1st and 2nd day after injection. I also feel tired on the 2nd and 3rd day, but I am not as hungry. I do notice that when I eat poorly, I have explosive BMs, and when I eat clean, I feel constipated. I do notice the weight loss on the 2.5 mg dose but can't move into 5.0 due to shortages, and I am hoping it's not like my experience with Wegovy, and I'll have to stop the progress due to the shortage of dosages."

• Ano...
• Taken for 1 to 6 months
• July 9, 2025

For Weight Loss (Obesity/Overweight) "So far the experience for me has been difficult. The weight loss is slow but pretty much steady. I’m experiencing nausea, stomach pain, and fatigue. I’m still trying to stick it out, hoping that it will subside."

• agm...
• Taken for 1 to 6 months
• December 18, 2024

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 16 weeks. I have lost 23 lb. I am a 6'3" 74-year-old man. I wanted a kick start to get to my goal, which I am at. Except for three weeks at 5 mg, I have been on 2.5 and am now after a brief go at 5 mg. My experience has been generally acceptable, but nausea and fatigue are a real challenge. No vomiting or diarrhea. I have had some acid reflux. The key has been to eat good clean food and stay away from fried or greasy. I have reduced my alcohol intake, but they are empty calories, and why do it? It just makes it tougher. The reason I drink some is usually social, but I have found it easier to abstain than I expected. Here's the deal: I think people lose weight on these drugs because they don't want to get sick and choose to behave and stay at a calorie deficit, and bingo, the math kicks in. It's not rocket science. I have taken a week off while on an overseas trip. Again, I didn't want to get sick. I am about to take another week off."

• Deb...
• Taken for 1 to 2 years
• December 20, 2024

For Weight Loss (Obesity/Overweight) "Worked great, however, I experienced nausea/dry heaves the 1st and 2nd day after injection and intermittent nausea throughout the week before the next injection. I've lost 20% of my body weight. I believe this medication needs to be taken forever, or all the weight will return."

• Kel...
• Taken for less than 1 month
• July 8, 2025

For Weight Loss (Obesity/Overweight) "I just started my 1st shot Mon July 7th 2025. I'm 39 and weigh 231 lbs. Throughout the day, I was fine and eating regularly as usual, but the next morning... OMG! The nausea is horrible, but that won't stop me from losing the 40 lbs I'd like to lose. Drink lots of water, listen to your body, and get plenty of rest."

• Suz...
• Taken for 6 months to 1 year
• February 26, 2025

For Weight Loss (Obesity/Overweight) "I began my weight loss journey in late January 2024. Over the next 12 months, I lost 40 pounds. However, I've hit a plateau for the past four months, since the end of November 2024, and it's now February 25, 2025. I still need to lose at least another 40 pounds. Zepbound has been a significant help in my journey. My clothes fit much better, and I've gone from a size XXL to a medium. In addition to Zepbound, I also strength train, maintain a healthy diet, and track my calorie intake. The only side effects I've experienced with Zepbound are occasional acid reflux, mild nausea, and some constipation. Currently, I am on 12.5 mg, but my doctor has decided to update my dosage to the 15 mg to see how I do on that dosage. Hopefully, it will kick me over the plateau and I will end up losing the next 40 pounds that I need to. Other than that, I love Zepbound. I think it’s great."

• Ang...
• Taken for 6 months to 1 year
• February 27, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound in August 2024. I initially weighed 255 lbs. I have since lost 110 lbs! I went from a size 20 to a 10! It is still very unreal to me. I am now on 15 mg and still feel great. I drink a protein shake in the morning and a small portion for dinner. The only side effect is nausea."

• Ano...
• Taken for 1 to 6 months
• June 19, 2025

For Weight Loss (Obesity/Overweight) "I am up to a 12.5 dose, almost 4 months on Zepbound. I have only lost 11 lbs. I am on a calorie-restricted diet, 1400 cal per day. I don’t feel a lot of hunger and my cravings are not many. I am disappointed in the loss rate, but if it keeps me from gaining back the weight, I’ll be happy. My only side effects have been constipation and minor nausea."

• Whi...
• Taken for 1 to 6 months
• August 17, 2024

For Weight Loss (Obesity/Overweight) "I have been taking this medication now approaching the 6-month marker, and it has been wonderful for weight loss in my experience so far! I did my starter 2.5 mg dose for the first month and then went to the 5 mg and stayed there for 4 months before deciding to go up to the 7.5 mg, which is what I am currently on. I have definitely experienced some of the side effects, but they are pretty mild and typically only happen the day after taking my weekly shot, and then it gets better except for 1. I am always very nauseous the day after the shot when changing doses, but once I've been on a dose for a couple weeks, the nausea lessens quite a bit. But something that just randomly started happening about halfway into all of this, I started having major skin irritation with the injection spot, which freaked me out only because I had been taking it for months before it started happening just out of nowhere, and it wasn't when I changed a dose or done anything differently, and it's continued to happen every time!"

• dfx...
• Taken for less than 1 month
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I started May 2024 with a compounded GLP-1, which worked great (some nausea), 186lbs down to 147lbs. However, I stopped working, so I switched to trizepitide 2.5 this week. Absolutely no side effects. I've already lost a pound. Once I get below 140, I'm going to go to only 2 shots a month for maintenance. I'm doing this through a clinic. I can't say enough how great I feel. I've done every diet in the book. It's the best gift you'll give yourself ever. I pay $300 for 4 shots."