Zepbound User Reviews & Ratings (Page 2)

• 2go...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "On week 5 of Zep. Goal to lose 20-25 lbs. Received a 2.5 mg 'loading' dose, I split it into 1.25 doses 3 days apart for the first 2 weeks as I tend to react strongly to meds. I had a bit of anxiety and fatigue on this dose and appetite suppression that waned by week 2, so I increased to 2.5 in one shot for weeks 3 and 4. Less anxiety/fatigue but more nausea and constipation, still manageable. I received a 5 mg dose in the mail at week 4 but had already lost 15 lbs on the 2.5 dose for 4 weeks. Week 5 - I tried the 5 mg. The next day, I was so sick to my stomach and nauseous that I struggled to eat or drink at all. I was dizzy and felt terrible, depressed, and kept getting the long bouts of hiccups. I will be at goal soon and plan to switch to metformin to maintain weight. For me, this med is miraculous, but I do not feel great on it. (For reference - I have a mental health diagnosis and pre-existing mild gastrointestinal issues, MTHFR gene variant)"

• Bor...
• Taken for 1 to 6 months
• January 17, 2025

For Weight Loss (Obesity/Overweight) "I’m almost 46. I have been struggling with weight loss all my life, joined food addiction programs, and tried other diets, and nothing worked. I lost some but gained it right back. I started at 220, but in numbers, I was not diabetic, so my insurance wouldn’t cover weight loss medication. My doctor worked with me for months and kept trying until it was finally approved. I did manage to get down to 186 pounds before starting on Zepbound. I have lost an additional 22 lb in 2.5 months! I’m at 164 now, and I haven’t been here in years. I can relate to many of the comments here. I don’t think about food, no cravings. I feel satisfied. I have been doing one meal a day, and I feel great. I don’t feel anxious, deprived, or hungry. I don’t worry about what I’m going to eat next. I don’t catch myself always snacking. It’s changed my brain in a way that I’m at peace. Just started on a 7.5 gm, and I did have some nausea just the very first day, but no other side effects."

• Tpo...
• Taken for 1 to 6 months
• March 3, 2024

For Weight Loss (Obesity/Overweight) "50-year-old female with 100 lbs to lose and PCOS. Been on Zepbound for 6 weeks (just took 7th shot). Minimal side effects. Occasional nausea, headaches, and sore muscles, usually the day after injection, but they go away by the next day. Taking the 5 mg dose right now. I have been getting large injection site rashes with itching, burning, and swelling with the last 3 doses. The swelling and itching go down after 3-4 days, but the red spots are still visible from all 3 of the previous doses. I didn't get this with the 2.5mg dose at all. Hoping it was just this last box of the medicine and the next will be better. I have only lost 5 lbs in the 6 weeks I have been on it, which has been very disappointing. It has lowered my blood pressure though. It was on the high side of normal before, now it's perfect. Really hoping that going up to the 7.5mg dose will start having better results for me as I have got a long way to go, and hopefully the skin reactions won't get worse."

• And...
• Taken for 1 to 6 months
• June 8, 2024

For Weight Loss (Obesity/Overweight) "Started out great. Moved to 5.0 and had AWFUL vomiting on day 3 after injection. Dr. tried to move me back to 2.5 but Rx store was unable to get it. Went 5 weeks before it was restocked. Started 2.5 again with 0 effect. And I mean zero. Moved to 5.0 and the nausea is there, but so far, no vomiting. What concerns me is that I have suddenly been struggling with an elevated pulse and higher than normal BP. Wasn't an issue before, so not sure if it's related or incidental. May stop it because I just don't feel good. In addition over the 5 months of on and off again, I am down 4 pounds...and following a reasonable diet plan. Discouraged."

• Vio...
• Taken for less than 1 month
• May 30, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound about a week ago. Only had 1 injection, but for me personally, as soon as I did the injection, I immediately began to feel nauseated and dizzy for a good couple of hours, but then it subsided. I did have some anxiety about the side effects, and sometimes when I do have anxiety, I will feel nauseous and dizzy as well, so I really can’t tell if that was from the injection or anxiety. Either way, it stopped. Since then, I barely eat. I NEVER feel hungry at all, and when I do, I eat hardly a handful of something before I feel full and stop eating. I don’t know if that’s normal. I’m supposed to get 60 grams of protein a day. I drink 2 of those 30 grams of the Premier protein shakes, not my favorite, but it will do, and that keeps me feeling full for pretty much the ENTIRE day. I don’t snack at all anymore. Again, I’ve only had 1 injection but have noticed some immediate changes."

• Rev...
• Taken for 1 to 6 months
• April 6, 2024

For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for about 3 months now and have lost 18 lbs. The experience has been mostly unpleasant. The gastric issues that accompany the medication are almost unbearable. The desire to eat did not go away, and I mostly did not eat because I was always so nauseated and experiencing acid reflux. Every day has been miserable. It did make you feel good but not in a satisfied way, just full like you ate way too much to the point of feeling sick. It feels great to have lost 18 lbs, but I will probably not continue the shots due to the gastric issues."

• Jus...
• Taken for less than 1 month
• December 28, 2024

For Weight Loss (Obesity/Overweight) "After my second 2.5 shot, the side effect symptoms are too much for me to handle. I’ve barely kept any food down except for a day and a half before my second shot. I can’t find a way to prevent acute nausea, and the vomiting is now making me weak. I knew there would be side effects, but for me, this medication doesn’t work for my body. I chose to discontinue the medication and will work with my doctor to see what other options may work for me. I have been unable to participate in family and home life, feeling trapped between being so sick I can’t leave my bed and spending a lot of time vomiting or feeling like I will if I try to move or drink water. I hoped this would be the tool to help me on a healthier path, and it’s not the right one for me, but I can see how it would possibly help others if they aren’t affected by side effects."

• Fin...
• Taken for 6 months to 1 year
• September 3, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound in March of this year, along with regular exercise and a more balanced diet. Since then, I have lost 65 lbs. For the first time in over 20 years, I am under 200 lbs. I feel great. I barely use my inhaler, my knees rarely hurt, and I can jog! My labs are all within normal limits, and I feel so much better about myself. I have very little side effects from ZB: nausea the day after I take it, intolerance to most alcoholic beverages, and I get hot after every meal. I’ll take those side effects any day if it means that I’ll continue to have my life back. I’m on the highest dose now and will continue until I reach my goal of 165. I’m 5’4'' and 44 yrs old. I’m not sure that I want to get back to my high school weight of 140 or less. Anyway, I’m not here to steer anyone, I just wanted to share how well it’s going for myself."

• Mat...
• Taken for 6 months to 1 year
• March 18, 2025

For Weight Loss (Obesity/Overweight) "Question: Why wouldn’t you use this to get a head start on a new life? I started on Monjaro for weight loss and had to switch to Zepbound after three months (insurance). I always dieted and would stall after 20 pounds. My ultimate goal was to lose enough weight to safely run again. After a year, I had lost 80 lbs and was able to start running. I just finished a half marathon, one year after starting this journey. The side effects of it are what is advertised; some nausea, it can hit you but goes away quickly, the heartburn was less with Zepbound than Monjaro, and the decrease in using the bathroom is a godsend for anyone experiencing IBS. The injection is not bad with the auto pen. Take the leap and change your life!"

• Ano...
• Taken for 1 to 6 months
• June 11, 2025

For Weight Loss (Obesity/Overweight) "As soon as I began at the 2.5 dosage, I modified my diet radically to mitigate or even entirely avoid the dreaded side effects of indigestion, nausea, constipation, heartburn, and vomiting. I also embarked on a free-weight program to build muscle. Fortunately, I’ve experienced none of the unpleasant side effects. I’ve titrated up after each 4-week dosage and am now in the middle of 7.5 mg. My doctor tells me I have lost more weight than most patients have at this point. I also have chronic inflammation, which extra weight exacerbates, and I’m watching carefully to see that marker decrease. That’s the good news. Zepbound has completely changed my relationship to food. I consider myself a “foodie.” That’s now behind me. I remind myself that it’s been only 10 weeks. I’m hopeful that at some point, I will be able to enjoy more of the foods that were once such a large part of my life."

• Tz0...
• Taken for 1 to 6 months
• April 12, 2024

For Weight Loss (Obesity/Overweight) "I am 64, 5’2” tall and weighed 210 when I started Zepbound with 2.5 mg on January 15, 2024. I had no side effects with 2.5 and lost 12 pounds the first month. I went up to 5.0 ml and still no side effects but lost only 5 pounds that month. Went up to 7.5 and started having mild nausea, diarrhea, and indigestion. Lost another 10 pounds that month. I'm on week 2 of 10 ml. Side effects are much worse. I've lost a total of 35 pounds but in week two my stomach physically hurts, nausea is much worse and so is diarrhea. I think I will not be able to complete the next two doses on 10 ml so looking to drop down to 5.0 for maintenance and hopefully continued weight loss."

• Hed...
• Taken for 1 to 2 years
• July 15, 2025

For Weight Loss (Obesity/Overweight) "I love Zepbound as it is the only thing that has helped me lose weight easily. After reading the reviews on here, my approach has been somewhat different as I refused to give up any foods or alcohol as that isn't real life for me. I walk 4 miles a day but haven't done real cardio or weight lifting very often so that is next. I have been on it for 13 months and started at 190 and am at 152, which is less than my high school weight/5'6'' and was a college athlete, so a very muscular type build. I am ecstatic at this weight but scared to go off Zepbound as I can control my food addictions with it and don't eat 2000 calories at midnight anymore. I get full very quickly so I am eating way less than my old norm of 4000 calories a day. :-) I am at 12.5 mg and the side effects I have had are mostly fatigue and my hair breaking off. At first, I had nausea and injection site swelling, but that went away after the first month."

• Ste...
• Taken for 6 months to 1 year
• October 3, 2024

For Weight Loss (Obesity/Overweight) "I've been on the shot for 5 months now, and at first, the appetite suppression was strong, with no side effects. After I went up in dose month two, I had extreme bloating and nausea to the point where I nearly took myself to the emergency room. Since then, the side effects have gone down, and the only one I deal with regularly is heartburn. Ask your doctor for Zantac and keep it and Tums on you at all times. Thankfully, it has mostly subsided, and I'm down 80 pounds with moderate exercise in 5 months. I have basically 0 appetite most days and have grown to work with it. I'd give it a 4/5. It's not easy, but if you're serious about losing weight and taking back control of your body, do it. Make sure you work out and follow a strict diet while you're doing it to get the most out of the medication. ALSO! Go to the manufacturer Lilly's website and sign up for the savers card. Saves me $300 a month with insurance."

• Ano...
• Taken for 6 months to 1 year
• May 8, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound on July 1, 2024, after much research and many discussions with my primary care provider. My insurance did not cover the cost and, at that time, it was difficult to get access to some of the other weight loss drugs. I was able to get Zepbound at my local Walmart Pharmacy and decided to go for it in spite of the cost. At the beginning of my weight loss journey, I was 74 years old, 5'5" and 190 lbs. I started at the lowest dose, 2.5 mg, and began losing weight right away. The only side effect I experienced was slight nausea for a day or so after each injection. It also lowered my blood pressure and I was able to stop taking blood pressure medication. I never exceeded the 7.5 mg dose and am still using it sporadically (probably not the proper way to go about it). I was able to go from 190 lbs. down to 135 lbs. in 9 months."

• mar...
• Taken for 1 to 6 months
• May 1, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound late January. I was generally a small person and was the same size for over 25 years. However, with menopause and COVID combination, I gained over 25 pounds and my BMI went from a 24 to a 30 in the past 4 years. Both of my parents were diabetic, therefore, my risk factors were great. Initially, I felt nauseous for a few days, but the nausea went away. I started on 2.5 mg and lost 13 pounds in the first month. Moved to 5 mg the second month. I was down 18 pounds after month 2. No side effects from the meds. I went to 7.5 for the 3rd month and am still on it. I have lost 24 pounds. I am also exercising more. I try to put in 10k steps at least 5 days a week and exercise for 30 minutes 4 days a week. I am 5'2 and started at 166 pounds. I am down to 142 now and have more energy. My A1C was 6.1 when I started and is now 5.7. My cholesterol did go up from 212 to 267, however, I attribute this to the rapid weight loss and will test again in 6 months."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• Ano...
• Taken for 1 to 6 months
• July 9, 2025

For Weight Loss (Obesity/Overweight) "So far the experience for me has been difficult. The weight loss is slow but pretty much steady. I’m experiencing nausea, stomach pain, and fatigue. I’m still trying to stick it out, hoping that it will subside."

• Day...
• Taken for less than 1 month
• February 2, 2025

For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."

• Anonymous
• Taken for 1 to 6 months
• December 17, 2024

For Weight Loss (Obesity/Overweight) "I am 5'2" and 46 years old. I started Zepbound on 8/20/2024 at 166 pounds. I took the 2.5 mg dose for one month, then increased to 5 mg in Oct. and Nov. I had very mild side effects, and I steadily lost weight until last week. I have now increased to the 7.5 mg dose, and the nausea and diarrhea are pronounced. I'm down 30 pounds, but I may switch back to the 5 mg dose if the side effects don't subside."

• Anonymous
• Taken for less than 1 month
• November 29, 2024

For Weight Loss (Obesity/Overweight) "First dose 2.5 today, and already my appetite is none. I only ate a very small portion plate and drank nothing but water. It wasn't until I tried to have my daily cup of coffee when I felt very nauseated after only a few steps. Day 1, and I'm here to say I know it's going to work out (I'm hoping I can build my coffee/frappe tolerance back up, I LOVE my coffee)."

• Anonymous
• Taken for 1 to 6 months
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 49-year-old female. Started on 2.5 mg of Zepbound at 201. Lost some weight quickly and got to 191, then stopped. Second month, they bumped me to 5 mg. I only got sick once. It was nausea. I started losing again. Got down to 185. Then, for reasons I can’t explain, I gained 2 lbs despite walking and tracking food. On my 3rd shot, I was very lethargic for a whole weekend after the shot. I have no energy, and I am taking nothing else. I hope it goes away soon and I start losing again. It’s not a magic bullet. You have to track your food and exercise too (which is hard with lethargy)."

• Mrs...
• Taken for 6 months to 1 year
• October 8, 2024

For Weight Loss (Obesity/Overweight) "Zepbound made weight loss easy. I have lost 40-50 pounds on it. Very little side effects outside of a little nausea occasionally. It’s so easy to use with the prefilled injector. I am now maintaining, and my doctor is happy with my weight. I’m so excited, I haven’t been this thin in 30 years! The only downside for me is the cost. It’s quite expensive even with the coupon. I’m not sure how much longer I can keep paying at this price."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• Ms ...
• Taken for 6 months to 1 year
• March 11, 2025

For Weight Loss (Obesity/Overweight) "I started my Zepbound journey in August 2024. I have been on .50 the whole time. I've lost 40 lbs using this medicine, which is amazing! In February, out of nowhere, I started to get side effects after my shot: nausea and diarrhea. Thinking it was the flu, I nursed myself back. Shot day is Wednesdays. On Saturday, the diarrhea came back again. I truly am excited for my weight loss journey but am literally pooped out."

• Mom...
• Taken for 1 to 6 months
• November 19, 2024

For Weight Loss (Obesity/Overweight) "I have had great success with Zepbound, currently on 15 mg. Been on it for 6 months, 67 lbs down. Went from a size 20 pants to a 12. I have had some nausea and vomiting. It’s easy to use. I’m squeamish when it comes to shots, so for the first 2 months, my husband had to inject me. I got used to it and can now do it on my own. I feel so much better about myself and so much healthier."