Zepbound User Reviews & Ratings (Page 2)
Zepbound has an average rating of 8.9 out of 10 from a total of 305 reviews on Drugs.com. 86% of reviewers reported a positive experience, while 1% reported a negative experience.
Reviews for Zepbound
- Rev...
- Taken for 1 to 6 months
- April 6, 2024
For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for about 3 months now and have lost 18 lbs. The experience has been mostly unpleasant. The gastric issues that accompany the medication are almost unbearable. The desire to eat did not go away, and I mostly did not eat because I was always so nauseated and experiencing acid reflux. Every day has been miserable. It did make you feel good but not in a satisfied way, just full like you ate way too much to the point of feeling sick. It feels great to have lost 18 lbs, but I will probably not continue the shots due to the gastric issues."
- Fin...
- Taken for 6 months to 1 year
- September 3, 2024
For Weight Loss (Obesity/Overweight) "I started Zepbound in March of this year, along with regular exercise and a more balanced diet. Since then, I have lost 65 lbs. For the first time in over 20 years, I am under 200 lbs. I feel great. I barely use my inhaler, my knees rarely hurt, and I can jog! My labs are all within normal limits, and I feel so much better about myself. I have very little side effects from ZB: nausea the day after I take it, intolerance to most alcoholic beverages, and I get hot after every meal. I’ll take those side effects any day if it means that I’ll continue to have my life back. I’m on the highest dose now and will continue until I reach my goal of 165. I’m 5’4'' and 44 yrs old. I’m not sure that I want to get back to my high school weight of 140 or less. Anyway, I’m not here to steer anyone, I just wanted to share how well it’s going for myself."
Frequently asked questions
- Ozempic Side Effects to Watch For
- Zepbound Vs Mounjaro: Complete Comparison Guide for Weight Loss and Diabetes Treatment
- Why am I not losing weight on Mounjaro?
- How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?
- Mat...
- Taken for 6 months to 1 year
- March 18, 2025
For Weight Loss (Obesity/Overweight) "Question: Why wouldn’t you use this to get a head start on a new life? I started on Monjaro for weight loss and had to switch to Zepbound after three months (insurance). I always dieted and would stall after 20 pounds. My ultimate goal was to lose enough weight to safely run again. After a year, I had lost 80 lbs and was able to start running. I just finished a half marathon, one year after starting this journey. The side effects of it are what is advertised; some nausea, it can hit you but goes away quickly, the heartburn was less with Zepbound than Monjaro, and the decrease in using the bathroom is a godsend for anyone experiencing IBS. The injection is not bad with the auto pen. Take the leap and change your life!"
- Tz0...
- Taken for 1 to 6 months
- April 12, 2024
For Weight Loss (Obesity/Overweight) "I am 64, 5’2” tall and weighed 210 when I started Zepbound with 2.5 mg on January 15, 2024. I had no side effects with 2.5 and lost 12 pounds the first month. I went up to 5.0 ml and still no side effects but lost only 5 pounds that month. Went up to 7.5 and started having mild nausea, diarrhea, and indigestion. Lost another 10 pounds that month. I'm on week 2 of 10 ml. Side effects are much worse. I've lost a total of 35 pounds but in week two my stomach physically hurts, nausea is much worse and so is diarrhea. I think I will not be able to complete the next two doses on 10 ml so looking to drop down to 5.0 for maintenance and hopefully continued weight loss."
Are you taking this medicine?
Your review helps others make informed decisions.- Ms ...
- Taken for 6 months to 1 year
- March 11, 2025
For Weight Loss (Obesity/Overweight) "I started my Zepbound journey in August 2024. I have been on .50 the whole time. I've lost 40 lbs using this medicine, which is amazing! In February, out of nowhere, I started to get side effects after my shot: nausea and diarrhea. Thinking it was the flu, I nursed myself back. Shot day is Wednesdays. On Saturday, the diarrhea came back again. I truly am excited for my weight loss journey but am literally pooped out."
- wen...
- Taken for 1 to 6 months
- March 26, 2025
For Weight Loss (Obesity/Overweight) "I have only taken it for 5 weeks. I have had a lot of nausea and acid reflux. Hopefully, they go away, but when I started, I weighed 174, and 5 weeks later, I am at 165, so it's working. Side effects seem to be decreasing, so I'll keep going for now."
More FAQ
- How much is Zepbound with or without insurance?
- Can you get tirzepatide from a compounding pharmacy?
- How long does it take for Zepbound to work?
- How do Zepbound and Wegovy compare?
- Ste...
- Taken for 6 months to 1 year
- October 3, 2024
For Weight Loss (Obesity/Overweight) "I've been on the shot for 5 months now, and at first, the appetite suppression was strong, with no side effects. After I went up in dose month two, I had extreme bloating and nausea to the point where I nearly took myself to the emergency room. Since then, the side effects have gone down, and the only one I deal with regularly is heartburn. Ask your doctor for Zantac and keep it and Tums on you at all times. Thankfully, it has mostly subsided, and I'm down 80 pounds with moderate exercise in 5 months. I have basically 0 appetite most days and have grown to work with it. I'd give it a 4/5. It's not easy, but if you're serious about losing weight and taking back control of your body, do it. Make sure you work out and follow a strict diet while you're doing it to get the most out of the medication. ALSO! Go to the manufacturer Lilly's website and sign up for the savers card. Saves me $300 a month with insurance."
- Anonymous
- Taken for 1 to 6 months
- December 17, 2024
For Weight Loss (Obesity/Overweight) "I am 5'2" and 46 years old. I started Zepbound on 8/20/2024 at 166 pounds. I took the 2.5 mg dose for one month, then increased to 5 mg in Oct. and Nov. I had very mild side effects, and I steadily lost weight until last week. I have now increased to the 7.5 mg dose, and the nausea and diarrhea are pronounced. I'm down 30 pounds, but I may switch back to the 5 mg dose if the side effects don't subside."
- Sha...
- Taken for 1 to 6 months
- December 1, 2024
For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."
- Jus...
- Taken for less than 1 month
- December 28, 2024
For Weight Loss (Obesity/Overweight) "After my second 2.5 shot, the side effect symptoms are too much for me to handle. I’ve barely kept any food down except for a day and a half before my second shot. I can’t find a way to prevent acute nausea, and the vomiting is now making me weak. I knew there would be side effects, but for me, this medication doesn’t work for my body. I chose to discontinue the medication and will work with my doctor to see what other options may work for me. I have been unable to participate in family and home life, feeling trapped between being so sick I can’t leave my bed and spending a lot of time vomiting or feeling like I will if I try to move or drink water. I hoped this would be the tool to help me on a healthier path, and it’s not the right one for me, but I can see how it would possibly help others if they aren’t affected by side effects."
- Anonymous
- Taken for less than 1 month
- November 29, 2024
For Weight Loss (Obesity/Overweight) "First dose 2.5 today, and already my appetite is none. I only ate a very small portion plate and drank nothing but water. It wasn't until I tried to have my daily cup of coffee when I felt very nauseated after only a few steps. Day 1, and I'm here to say I know it's going to work out (I'm hoping I can build my coffee/frappe tolerance back up, I LOVE my coffee)."
- kel...
- Taken for 1 to 6 months
- March 12, 2025
For Weight Loss (Obesity/Overweight) "I am a 45-year-old female starting weight 243... I just took my fifth shot a few minutes ago, and I have lost a total of 26 lb since my first shot. Food noise is completely gone, and I find myself not able to eat anything until the day before my shot. I do drink a lot of water and have no cravings for sweets like I used to. I have done moderate exercise in the evening and tried to force myself to eat some source of protein throughout the day. I also take women's one-a-day gummies and I feel fantastic! The very first shot I took, the first few days I felt horrible, like I had the flu and had been hit by a bus. Since then, no side effects except for very mild nausea, which I take promethazine to help, and it does wonders. My sleeping patterns have gotten better, and my energy has increased. It states for my age and height at 5'9, I should weigh 167. I honestly feel like I would look very sickly if I got that small, so my goal is basically just to fit in my pants from last summer, lol."
- Mrs...
- Taken for 6 months to 1 year
- October 8, 2024
For Weight Loss (Obesity/Overweight) "Zepbound made weight loss easy. I have lost 40-50 pounds on it. Very little side effects outside of a little nausea occasionally. It’s so easy to use with the prefilled injector. I am now maintaining, and my doctor is happy with my weight. I’m so excited, I haven’t been this thin in 30 years! The only downside for me is the cost. It’s quite expensive even with the coupon. I’m not sure how much longer I can keep paying at this price."
- Anonymous
- Taken for 1 to 6 months
- January 12, 2025
For Weight Loss (Obesity/Overweight) "I am a 49-year-old female. Started on 2.5 mg of Zepbound at 201. Lost some weight quickly and got to 191, then stopped. Second month, they bumped me to 5 mg. I only got sick once. It was nausea. I started losing again. Got down to 185. Then, for reasons I can’t explain, I gained 2 lbs despite walking and tracking food. On my 3rd shot, I was very lethargic for a whole weekend after the shot. I have no energy, and I am taking nothing else. I hope it goes away soon and I start losing again. It’s not a magic bullet. You have to track your food and exercise too (which is hard with lethargy)."
- Day...
- Taken for less than 1 month
- February 2, 2025
For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."
- Mom...
- Taken for 1 to 6 months
- November 19, 2024
For Weight Loss (Obesity/Overweight) "I have had great success with Zepbound, currently on 15 mg. Been on it for 6 months, 67 lbs down. Went from a size 20 pants to a 12. I have had some nausea and vomiting. It’s easy to use. I’m squeamish when it comes to shots, so for the first 2 months, my husband had to inject me. I got used to it and can now do it on my own. I feel so much better about myself and so much healthier."
- KJa...
- Taken for 1 to 6 months
- December 27, 2024
For Weight Loss (Obesity/Overweight) "Fantastic! I have never felt better! Lost 14 lbs in 1 1/2 months minimal side effects a little nausea here and there. Nothing crazy, truly a miracle drug for weight loss, the bonus is inflammation in general is better, and I am hoping to get off my BP meds soon!"
- Anonymous
- Taken for 1 to 6 months
- January 20, 2025
For Weight Loss (Obesity/Overweight) "I am a 48-year-old female and have been on this for 6 weeks. I am down 9.2 lbs and haven't had a lot of side effects. With the dose increase to 5 mg, I noticed intermittent nausea, but nothing that prevents me from daily tasks or from taking the next shot. I am rarely hungry and get full very quickly. The shot doesn't really hurt, but I do bruise at the site. Weight loss isn't super fast, which is good because I don't want to have a lot of loose skin."
- Tim...
- Taken for 1 to 6 months
- July 27, 2024
For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."
- Ang...
- Taken for 6 months to 1 year
- February 27, 2025
For Weight Loss (Obesity/Overweight) "I started Zepbound in August 2024. I initially weighed 255 lbs. I have since lost 110 lbs! I went from a size 20 to a 10! It is still very unreal to me. I am now on 15 mg and still feel great. I drink a protein shake in the morning and a small portion for dinner. The only side effect is nausea."
- kan...
- Taken for 1 to 6 months
- December 21, 2024
For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."
- get...
- Taken for 1 to 6 months
- June 4, 2024
For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost 3 months now. I've been at 2.5 the whole time as we are struggling to get any higher doses from back order. I have lost over 20 pounds already. My first shot, my side effects weren't horrible, but I also deal with nausea daily. I also had really bad pain in my upper back, neck, and shoulders like I had whiplash, but that was gone after 48 hours and was nowhere near as bad the 2nd shot. And then nothing after that. This past week though, I've been waking up starving, like I haven't eaten in days. I normally eat dinner around 5:30ish and have a small snack around 8ish, and I haven't had this before. The only other thing I've noticed and just read it could be a side effect is my hands have been super itchy, like I'm having an allergic reaction to something, which I've been thinking that's what's going on. But overall, my side effects have been very minimal, and the benefits majorly outweigh them."
- Lyn...
- Taken for 1 to 6 months
- December 20, 2024
For Weight Loss (Obesity/Overweight) "I am happy with the results so far. I have lost 29 lbs in 13 weeks. My goal is 75 lb weight loss. My appetite is far less, and my cravings for sugar have much improved. I have had some constipation and 1 or 2 episodes of nausea but did not vomit. You have to drink water! I started on 2.5 mg and was increased to 5 mg. I'm worried to go to a higher dose due to potential increased side effects, as I have a history of kidney issues. However, since I started the medicine, my Hga1c is normal and lipid panel perfect."
- Deb...
- Taken for 1 to 2 years
- December 20, 2024
For Weight Loss (Obesity/Overweight) "Worked great, however, I experienced nausea/dry heaves the 1st and 2nd day after injection and intermittent nausea throughout the week before the next injection. I've lost 20% of my body weight. I believe this medication needs to be taken forever, or all the weight will return."
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Your review helps others make informed decisions.More about Zepbound (tirzepatide)
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For Weight Loss (Obesity/Overweight) "Began 1 month ago, March 2025, starting with 2.5 mg at 210 lbs, and I am 5'4", size 14. 2nd month, same dosage, 2.5 mg. Now my weight is 183 lbs, size 10. I do have nausea, but it goes away when I drink plenty of water/seltzer. I can eat what I want, but small portions, and I can put the fork down. I take the shot at bedtime. I have only used my arms. It does not hurt. I am happy this is working."