Tirzepatide and Vomiting: What Users Say (Page 3)

• Xer...
• Taken for 1 to 6 months
• May 18, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Began taking on January 12, 2025. Moved up dosage monthly under supervision of Physician’s Assistant from 2.5 mg to 10 mg. No noticeable side effects. Lost 30 lbs between start date and May 18, 2025 (from 268 to 238 lbs). Previously tried Ozempic and Wegovy each for about two weeks each. Had horrible side effects (explosive diarrhea and vomiting) bad enough to discontinue. Was apprehensive about Zepbound — but experience was completely different. Only exception was May 17-18, when consumed about three glasses of wine (previously had no alcohol during usage period). Had explosive diarrhea just like when using Ozempic and Wegovy. Tested for COVID on May 18, but result was negative. Intend to continue with Zepbound (despite the predatory cost — over $500/month out of pocket but with some insurance). Intend to avoid alcohol consumption and see whether side effects diminish. Pleased with Zepbound results thus far."

• bry...
• Taken for 6 months to 1 year
• March 10, 2025

For Weight Loss (Obesity/Overweight) "The best thing that has ever happened to me. Genuinely. I started in August at 264 lbs, now in March I'm 175 lbs. I have about 25 more pounds to lose, I'm just now hitting my plateau. I'm honestly very comfortable and happy at this weight, so I am not too stressed about the scale for reasons other than aesthetics. The first 3 months, I did throw up anything that wasn't saltine crackers, but things got better. I feel nauseous occasionally, but I don't actually vomit anymore. It is important to note that this is not a magic potion, you will not lose weight if you continue to eat junk. If I have an off day, I could be 3 lbs heavier the next day. My weight fluctuations are more than they were when I was heavier. So you need to help the medication help you. I finally feel like a normal person. I finally have normal eating habits. Food no longer controls me. I will never let anyone make me feel guilty for taking this. I see this as a medication like an antidepressant. I have my life back."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."

• CWe...
• Taken for 6 months to 1 year
• May 17, 2023

Tirzepatide for Type 2 Diabetes "I started taking Mounjaro in August of '22. My doctor started me on it for Type 2 diabetes, but weight loss was also the goal. Started at 2.5 mg and now I’m on 15 mg. So far, I’ve lost 80 pounds with no effort. I’ve had little to no appetite. In regard to side effects, they’ve been very minimal. Some mild nausea, dry mouth, and constipation. I have vomited on 3 occasions, and it was due to drinking too much coffee, which made me too full. When reading reviews, please keep in mind that in terms of side effects, you just won’t know until you try the med. I personally have 2 other friends taking this, and their experiences have been pretty much like mine. Don’t let the horror stories scare you, because this medicine has been a true lifesaver for me."

• Mar...
• Taken for 1 to 6 months
• February 18, 2025

Tirzepatide "I have diarrhea, lower stomach pain, dry heaves every time I eat. I also have back pain, but that is not unusual. This pain might be a little different though. I didn't know to tell my doctor that I have had a vein occlusion in my right eye quite a few years ago. I don't know if that is important or not. I don't think I am reading as well. Not sure."

• Anonymous
• Taken for 1 to 6 months
• January 22, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Mounjaro is good for weight loss as it makes you less hungry and increases your energy levels, but the downside is the side effects, which range from nausea, vomiting, and constipation. It is not a miracle drug, and it is started at a low level and gradually increases, but it's a great kickstart if it's combined with a healthy lifestyle."

• SLW...
• Taken for 1 to 6 months
• January 22, 2025

For Weight Loss (Obesity/Overweight) "Extreme nausea and vomiting constantly. Only have 1-2 days per week that I feel decent. I’ve tried splitting my dosage each week, reduced the units that I inject, added a daily dose of omeprazole to help with the nausea/vomiting, and nothing seems to have helped. I’ve been on this journey since mid-Oct 2024 and it’s now toward the end of January. I kept thinking my body would get used to it eventually. I’ve lost from 167 lbs to 145. My plan going forward is to continue to lower the dose in hopes that I find a balance that works for me in order to continue to lose weight, but more importantly, to feel good doing it. I may be one of those few people who can’t use tirzepatide. Time will tell."

• TCC...
• Taken for less than 1 month
• January 28, 2025

For Weight Loss (Obesity/Overweight) "I am on week two of Tirzepatide and had nausea and vomiting almost every day. The vomiting is primarily at night, frequently accompanied by dry heaves, and can be intense. Diarrhea was the first week but better entering the second week. When I hit menopause, I had a very difficult time losing weight (I gained 20 pounds), even when on a clean diet with cardio four days a week. Since beginning meds, I have lost nine pounds and have very little to no appetite. My workouts are not as frequent due to the nausea and feeling tired. Even with negative side effects, I will stick with it in hopes my body will adjust. My weight gain has limited my ability to do my job, which requires a lot of bending and lifting. Just the nine pounds of weight loss has helped my knees not ache and more comfortable on the treadmill. I started at .25 mg, and the injection was no bother."

• SAJ...
• Taken for 1 to 6 months
• January 3, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Although I have had a lot of nausea and vomiting, I have gone from 216 lbs to 168 lbs. I was given Zofran, which helped a lot! I have an appointment with my doctor this coming Tuesday because I have developed a lump on my throat. This has me very concerned. The shot was very easy to use."

• ck6...
• Taken for 1 to 6 months
• December 16, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I am currently taking the 7.5 mg. I have currently lost 35# since I started my journey 7/2024. I have noticed that I can barely eat anything, feel very full after a few bites of food. To the point where I feel like vomiting and have a burning feeling like when you eat Halls cough drop, the menthol cool burn feel in my stomach and throat. It's NOT heartburn, it's different. Constantly thirsty, severe cotton mouth, especially at night."

• Jan...
• Taken for less than 1 month
• November 24, 2024

Tirzepatide for Type 2 Diabetes "I've only had 2 shots and 2 days until the next one. I find it very convenient to administer. However, I have had some nasty side effects! I've had diarrhea, nausea, vomiting, fatigue. I will continue taking the medication hoping the side effects will 'calm down.'"

• Cat...
• Taken for 6 months to 1 year
• August 11, 2024

Tirzepatide for Type 2 Diabetes "I have been using Mounjaro for a year now. First time I had negative effects, nausea, constant vomiting, and tiredness. My body got used to it, and ever since, my blood sugar has been in check. I really advise anyone who is diabetic."

• BOB...
• Taken for 1 to 6 months
• May 30, 2024

Tirzepatide for Type 2 Diabetes "Dropped 60 lbs! My numbers are nearly all under 100 now. Nausea and vomiting I was able to keep at bay with ginger chews or ginger gum. It suppressed my appetite, and I didn't want to overeat. Also, fewer cravings for sugary items."

• Car...
• Taken for 1 to 6 months
• April 30, 2023

Tirzepatide "I have insulin resistance, and I have taken my first dose of 5 mg this week. I have never been so dizzy in my life. I have to force myself to eat and drink. I could totally go all day without eating or drinking. When I force myself to eat, I get very nauseous or actually vomit. I have daily Zofran, which helps just keep the edge off, but eating is so hard. I know I need to eat, but I can’t. It’s great because I have never been able to feel full, I would just eat until it physically hurts. Now the binge restriction cycle has ended. I have lost weight and have felt good on the 2.5 mg dose, I have just had mild nausea. Because it’s hard to eat, I doubt I have even really hit 1200 calories. I know my blood sugar has been low, and I can’t even drive without feeling unsafe. I got an IV, and that helped, but I do not want to do the next 3 doses of 5 mg. I’m calling my doctor this week to follow up and double-check what he thinks. Crackers and Core Power milk have helped."

• Sco...
• Taken for 1 to 6 months
• March 18, 2025

Tirzepatide for Type 2 Diabetes "So far, so good until yesterday. I think I ate too much, and then the stomach pain started, and diarrhea followed all night. As I tried to ingest water, I became nauseous and had to throw up, but that decreased the pain. I think I’m just getting used to the drug since this was my first dose of 7.5 mg pen."

• Kym...
• Taken for 1 to 6 months
• July 22, 2024

For Weight Loss (Obesity/Overweight) "Ok, so month 2. Started at 220, down to 208. Roughly 2 lbs a week. Which, in my opinion, is good. My gut/brain communication is back, and now my tummy has been telling my brain that it's full in a timely manner, and I have no overwhelming desire to finish what's on my plate. I can let it go. I've stopped compulsively overeating, and actually feel satisfied with a small meal. I take liquid vitamins to try and stave off the plateau. But I don't think it's coming for a while. My goal weight is 140 lbs. I'm 4'11' and solidly built, so 140 is healthy on me. I have not had any negative side effects. No tiredness, nausea, cramps, constipation, or vomiting. My allergies have calmed down a lot. And my hypoglycemia has mostly righted itself. Meaning, I only experience it now on the last two days before my next shot. I just went up to 7.5 mg today. So far so good. I feel excellent and usually experience a bit of relaxation and euphoria about an hour after. I hope the higher dose will fix the hypoglycemia."

• dee...
• Taken for 1 to 6 months
• November 30, 2022

Tirzepatide for Type 2 Diabetes "I have been on Mounjaro since Sep 2022. I started off with the 2.5 mg for about a month with no issues. My provider then moved me to 5 mg in October. Once again, no issues, and I started losing weight. 15 lbs in about 6 weeks. I was then moved up to 7.5 mg in November and have been miserable ever since. I have no appetite, severe constipation, major headaches, and vomiting, and I am now having issues with low blood pressure (causing lightheadedness, dizziness, and vision issues), which I believe is being caused by my never wanting to eat or drink anything. I have informed my provider of this, and she is now wanting to send me to a cardiologist to make sure my heart is working properly. She has also decided to lower my dosage back to 5 mg. I am hoping this change helps because so far, my type 2 diabetes is under control, and my sugars have been fantastic!"

• Dru...
• Taken for 1 to 6 months
• April 12, 2025

Tirzepatide for Type 2 Diabetes "Currently on 750 Mounjaro. 2nd injection on Wednesday, had a 17-hour episode of vomiting and diarrhea on Sunday afternoon into Monday morning. I did not take the 3rd injection the following Wednesday. By Friday, I had the hungry horrors and joint pain in my hips and knees. Weight loss about 25 lbs, and my A1C only came down from 7.5 to 7.1 in the 5 months I’ve been on Mounjaro. If you take these meds, please listen to your body and the way it reacts to these meds."

• chi...
• Taken for 1 to 6 months
• September 15, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I was very ill after the first injection, vomiting for about 5 hours. Took a few months off and tried again, using only half the dose at first with no side effects. I have now started using the full dose. Other than some bloating and very mild stomach discomfort, I feel well. Hoping to not have to take it for too long and to train myself to be able to use portion control."

• me5...
• Taken for 1 to 6 months
• April 2, 2025

Tirzepatide for Type 2 Diabetes "Had to stop taking after 7 weeks of use. Total loss of appetite, very weak. When I try to eat, cannot do it due to gagging. The smell of foods upsets my stomach. Getting scary now, haven't used Mounjaro for 2 1/2 weeks and no improvement. No energy at all, hard to function."

• Anonymous
• Taken for less than 1 month
• October 6, 2024

For Weight Loss (Obesity/Overweight) "Prescribed 1.25 mg as the first dose (15 u). Chose to take 10 units since I never took it before. Had confusion, which subsided with sugar. Vomited three hours later. Voice a little raspy. Felt better, and symptoms calmed after 8 hours. I ate basically low-carb before starting and think I should have been asked what my diet is prior to taking. I’m a nurse for 20 years, so I have knowledge regarding symptoms and medication. Wish I would have started with 5 units instead. This medicine drastically reduced my hunger immediately."

• Che...
• Taken for 1 to 6 months
• December 1, 2024

Tirzepatide for Type 2 Diabetes "Makes me feel full faster and longer, but with reflux. Sometimes I am still full from yesterday if I eat. It turns to nausea, then vomiting, with epigastric burning and abdominal pain lasting 15 minutes to 45 minutes. Even with Zofran and whatever else I can take. Then I can't sleep, of course, so I'm up till 4:00 or 5:00 AM. I have lost weight on the 10 mg under the doctors' and nurse practitioners' diabetic care. Then I can go a week or two weeks without any negative symptoms at all."

• Dan...
• Taken for 1 to 6 months
• August 13, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I was taken Zepbound and have been vomiting, heart rate up, lack of water in my body, and been to the hospital three times because I keep throwing up. So what can I do and how long before it’s out of your body? It’s like the doctor doesn’t know what to do about the side effects of this drug from March until July. Off the seven point five mg got me all sick. Can't keep anything on my stomach."

• Bri...
• Taken for 6 months to 1 year
• January 6, 2025

For Weight Loss (Obesity/Overweight) "I have been on tirzepatide for six months, and I have lost 20 lbs. I will be honest and say that I am not currently exercising, so I would most likely be losing more if I were. I am in my mid-50s. I was on Ozempic in the past and lost approximately 20 lbs on that medication. I definitely had more side effects while I was on Ozempic. I feel like tirzepatide is slower to work, but the side effects are less intense because of that. I still have mild side effects of nausea, some vomiting, and constipation, but none of the side effects were as bad as when I was on Ozempic."

• kee...
• Taken for 1 to 2 years
• April 18, 2025

Tirzepatide for Type 2 Diabetes "I've been on Rybelsus, Trulicity, and Ozempic with minimal results both on A1C and weight loss, and lots of stomach issues. Presently on Mounjaro 10 mg for the past year, having gradually increased dosage along the way. Side effects are constipation, and approximately every three weeks I'll have an episode of stomach pain, sulfur burps, and vomiting. It's usually in the middle of the night, throwing up dinner and anything else eaten that day, sitting on my stomach all day. Vomiting, severe sweating, chills. After that, it passes, and I feel perfectly fine until weeks later it happens again. I can tolerate this side effect, and A1C is much better."