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Sulfamethoxazole / trimethoprim for Acne User Reviews (Page 5)

Brand names: Bactrim, Bactrim DS, Septra, Co-trimoxazole, SMZ-TMP DS, Septra DS, Bactrim Pediatric, Sulfatrim Pediatric, Bactrim IV Bethaprim Bethaprim Pediatric …show all brand names

Sulfamethoxazole / trimethoprim has an average rating of 7.7 out of 10 from a total of 185 reviews for the off-label treatment of Acne. 72% of reviewers reported a positive experience, while 17% reported a negative experience.

Reviews for Sulfamethoxazole / trimethoprim

  • DJ234
  • October 19, 2015

Bactrim DS (sulfamethoxazole / trimethoprim) "Have had severe acne for a long time and worked very well to clear up acne entirely with a few months. Unfortunately as soon as I go off of it, the acne slowly comes back. Still works amazing while on it though."

8 / 10
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  • Grace...
  • December 14, 2015

"This combination of antibiotics changed my life. Amazing is an understatement. It's not good for your liver to take it for more than 6 months continuously. So I've been on-and-off of it for 4 years now. It's the only antibiotic that cleared my face from acne. It changed my life. I hope it does the same for you."

10 / 10
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  • Hartmaa
  • Taken for less than 1 month
  • June 25, 2014

Bactrim DS (sulfamethoxazole / trimethoprim) "Works quite well for me. I have been on every med ever and even Accutane 3 times with no success. I have severe acne and simultaneous all over skin infection. 2 things- dairy if any kind sets it off and it's so much worse. Avoid dairy like the plague. 2- depends on how you skin is infected.my skin gets affected very often with Staph and so Bactrim and Keflex work really well. For people with p. Aches bacteria - erthromycin is awesome. But the sad fact is that over time it won't work as bacteria becomes resistant. I am seeing endocrinologist to find out what foods I am eating that seem to cause my body to make excess hormones and attack my skin. Best of luck all! Don't know what I'll do once I'm off Bactrim. I feel great and zero side effect"

9 / 10
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Frequently asked questions

  • Ta ta
  • Taken for 1 to 6 months
  • January 7, 2016

"I've been on this med for 2 weeks so far and will be continuing for about a month ...I have some bacterial acne since the birth of my second child :( and I couldn't handle it anymore !!) I feel so bad for all the people with bad experiences but I have to say I've had none...and I take the full dose twice a day I have had a wee headache a few times but nothing an advil didn't cure, so I guess use at your own risk? But working great for me personally"

8 / 10
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  • Anonymous
  • November 23, 2016

Bactrim DS (sulfamethoxazole / trimethoprim) "I have had acne for about 4 years now and I started bactrim about 2 years ago when I first started my skin looked amazing I was almost cleared up in a month. after about a year of being on it and my skin was doing well we went down to half a pill. about 6 months pasted and my skin started to break out again so we went back to a whole pill. my acne started to spread all over my chest, back and shoulders he decided that we would start 2 pills a day. I recently just went back and my skin was not doing well and I'm about to start accutane. I 100% believe I formed a resistance to the drug after being on it for so long. bactrim works amazing for short periods of time but in the long run it was not successful."

4 / 10
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Are you taking this medicine?

  • Anonymous
  • Taken for 1 to 2 years
  • March 9, 2018

SMZ-TMP DS (sulfamethoxazole / trimethoprim) "Started traveling and went off of normal acne medication. I had a huge flare up of the most painful acne I’ve ever had. It was almost cystic for about 6 months. Within just the 1st week of taking this people were noticing my skin clearing. This medicine was a miracle for my skin. It may be because my body has gotten used to it now (after a year) but unfortunately it doesn’t do much for me anymore. It keeps my face from exploding but I still have pimples. Overall this worked well and QUICKLY for me, which is especially rare with acne medication. Typically acne meds make your skin worse for months before you see improvement, if at all."

8 / 10
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  • great...
  • Taken for less than 1 month
  • September 11, 2019

"I have been on sulfamethoxazole with trimethoprim for a month and my skin is now awful. I have big painful red cysts all over my cheeks and forehead. Trimethoprim has completely ruined my skin and my self-esteem."

1 / 10
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  • Natas...
  • April 3, 2018

Bactrim DS (sulfamethoxazole / trimethoprim) "I am 36 and I was given tetracycline a couple years ago, made me nauseous but only for a hour or so then I’d be back to my normal self. Tetracycline worked wonders for my skin but unfortunately I became resistant to it a few months ago, I also tried minocycline which was ineffective. I’ve been having a really bad breakout since discontinuing the tetracycline. Recently went on Bactrim been on this for about 3 days and wow let me tell you I feel real shitty, the body aches are painful , the nausea really comes and goes all throughout the day, no rash which is a good sign but if this feeling doesn’t simmer down I won’t be able to continue this:( doesn’t look like there is any real solution for acne out there, my self esteem is so low and I feel helpless. So scared to try accutane due to the hair loss reviews ... that terrifies me. I can tell how horrible I feel from the Bactrim that I won’t last on this for much longer!"

4 / 10
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  • Nicks...
  • Taken for less than 1 month
  • July 23, 2012

"I've had really bad acne since I was 12 and now I'm 14. I've been taking it only for a week and its already working. Finally I have no shame in showing off my face in school, well not to much showing off. "

5 / 10
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  • PETEY
  • January 19, 2013

"At first, the acne went away and I was super excited, but then after the first week I began to grow huge acne all over my chin and jaw. I am taking two pills a day and the side effects are bad but I am willing to stick it out because in the end it should hopefully work. Its only on area where I get the pimples so I guess we will see how the next weeks go."

4 / 10
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  • Anonymous
  • July 29, 2020

Bactrim DS (sulfamethoxazole / trimethoprim) "I was prescribed Bactrim By my dermatologist for my acne and I must say it was the worst experience. At first I ignored the side effects but I initially experienced loss of appetite, night sweats, shivers, and had trouble falling asleep. After one week of taking it I experienced joint and muscle pain, which is ultimately the reason I stopped taking it. Such horrible side effects"

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • September 12, 2017

Bactrim (sulfamethoxazole / trimethoprim) "I've been on Bactrim and Aczone 7.5% for about a month now and my face is completely clear! I started noticing less breakouts the second week and by the end of the third week I had no new ones. I apply the Aczone in the morning before putting on makeup and then again at night after I wash my face. I'm not totally sure if it's the Bactrim or the Aczone that's clearing it up (maybe a combination?) but it's improved so much that even my bf mentioned that he noticed a difference this past week. I've also experienced no major side effects. My only concern is that once I slowly start to come off the medication, will the acne come back. Definitely give it a shot though if you've been struggling with acne and don't want to resort to Accutane!"

9 / 10
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  • Asha
  • Taken for less than 1 month
  • February 9, 2019

"WORST MEDICINE EVER!! It only took me a couple days to figure out what was causing me to feel like I had the flu and then I realized that it was this medication!! I was so tired that I could barely move, my muscles were sore and cramping, I had a terrible headache and I just felt like I was dying! No other kind of sickness or medicine has ever made me feel so bad! Never taking it again!!!"

1 / 10
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  • Severe...
  • December 31, 2016

"This was absolutely pathetic. My doctor informed the dermatologist that I needed a fast-acting medicine because she picked up on how my very severe acne affects my self esteem. As a result, he prescribed this, and I've been taking it alongside birth control with his instruction and oh my lord its made everything the worst its ever been. Cysts are coming out all over my face, and I've given the medicine more than enough time to take the junk out and start clearing my skin. Biggest mistake ever: DO NOT TAKE. I'm a teenager and I've been dealing with acne for 5 years now, and its been severe for 3 years and good lord do not take this it makes life so much more miserable. DON'T DO THIS TO YOURSELF."

1 / 10
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  • Acneman
  • August 11, 2018

"I started breaking out getting cystic acne when I started high school in 9th grade (age 13) but around the end of 10th grade is when my face completely broke out started taking the normal antibiotics like everyone else does for acne yet nothing worked till I went on Accutane for 5 months. It cleared up for about a year or less and then started getting minor breaks outs again so started using topical cream that fixed it then few months later cystic acne came back horribly worse the dermatologist even got scared or shocked when he saw me. I told him I didn't want to go on Accutane because of the side affects so I went on bactrim for 2 years when I was 17 which cleared me up to almost no break outs during whole time on bactrim. I'm 19 now and bactrim slowly stop working completely so I went to a new dermatologist and I am taking Accutane with bactrim now so we will see how it goes."

10 / 10
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  • Carol...
  • April 7, 2015

"This drug has literally saved me, I was so low with my acne, I still have spots but no way as bad as before. I've been taking this 2 months, I didn't see results like all everyone else has said in a couple of days etc, I thought I'd stick to this and I'm glad I did, I think a couple more months of this my face will almost be clear. My acne scars are now my problem, I use Retin A but I'm on the Hunt for another treatment. I hope this continues to work for me and please try this, before the harsh drug accutane :)"

8 / 10
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  • Anonymous
  • November 27, 2016

"This medication saved my skin and I couldn't be more happy with it. When I turned 20 I started to get cystic acne that would swell so bad that I wouldn't leave my house because I was so embarrassed. For a year I tried everything from high-end to drug store acne products, I even tried birth control,nothing worked. Within a week of taking Bactrim once a day my skin had no cysts or little bumps! I have a sensitive stomach and this medication did upset mine until I took it with milk and ate something light (cereal, bagel, granola bar). Always take it with food, I dont get any nausea if I take it with milk and cereal so I hope this helps if anyone is experiencing nausea from this medication. Wish I had tried Bactrim sooner!"

10 / 10
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  • Proba...
  • Taken for less than 1 month
  • September 6, 2019

"I have been taking this medicine for over 3 weeks now for acne and now my skin is worse than ever. Maybe it will take longer to work but currently not seeing any improvement. I really hope it will start to work now because I am resistant to all the ‘tetracyclines’ and trimethoprim is my last resort. I have been taking 200mg twice a day."

2 / 10
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  • piwo
  • Taken for less than 1 month
  • September 24, 2013

"This is an amazing antibiotic. I enjoy the mirror now. I have been using it for 3 weeks & I no longer have pimples after struggling with a breakout for almost 6 months. I take 2 in the morning & 2 in the evening. I use Ilotycin at night 3X a week to remove spots. I have tried Accutane & Doxy my acne got worse. Am hoping to have a flawless skin by this summer."

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  • emano
  • Taken for less than 1 month
  • December 29, 2020

Bactrim (sulfamethoxazole / trimethoprim) "I started using bactrim a week into December due to a hormonal explosion of acne from my birth control (due to a reaction). It cleared me up slightly after 1 week but once week 2 hit I broke out horribly and on day 20 I discovered I was allergic to it. My face swelled HORRIBLY I am literally unrecognizable. Bactrim has left me with worse acne than I started with. My entire cheeks are covered. Now left to resort to accutane. Weird because I used to take this on and off in high school (I am now in college) and it worked wonders. I either developed a bacterial resistance to the drug or just became allergic over the years. I highly recommend it if you've never taken it before and aren't allergic or can make it past the first month. I guess we will see how accutane works."

7 / 10
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  • ash
  • Taken for 1 to 2 years
  • December 7, 2020

Bactrim (sulfamethoxazole / trimethoprim) "I started using bactrim when I was going into my senior year of high school and it worked wonders for my cystic acne. I took it on and off throughout my first year of college and then stopped completely a year ago. My acne kinda came back and now I am on birth control which has completely RUINED MY SKIN. I am starting bactrim again this week as I am now a junior in college and hope to see good results like before. My skin was the best it ever was when I was taking this and I had no side effects"

10 / 10
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  • KaraKoe
  • December 16, 2009

"I had pretty severe side effects related to this medicine (I have no known problems with medications, so this was unusual). Symptoms did not appear until MONTHS of taking this medication. Side effects included: heart palpitations (like a "fight or flight" response...frequently, without cause) nausea, and overall tiredness (my body felt heavy), depression. It took me a long time to figure out this was due to this drug. It was a really terrible few months for me. Side effects stopped within 2-4 weeks after discontinuing this medication. On the plus side, this medicine was the most effective for my acne. My skin really cleared up tremendously. Not worth it though."

3 / 10
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  • Jack...
  • August 31, 2016

Bactrim (sulfamethoxazole / trimethoprim) "Before trying Bactrim, I had attempted a number of treatments. The last I had tried before it was Accutane, which I took for 5 months and which benefited me only for a short while. After my acne returned, my dermatologist suggested I try something different, and gave me a prescription for Bactrim. I was so happy as I didn't break out when I started it and it had cleared the acne from my face for an entire year. This month however the acne returned and it couldn't have done so at a worse time - I have planned a 2 month trip to South America with a group of friends. I can no longer rely on Bactrim and will need to find an alternative (I feel like I've tried every 'solution' there is)."

6 / 10
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  • EmShBu
  • Taken for 5 to 10 years
  • July 22, 2016

"I took sulfamethoxazole all throughout high school and my first year of college and throughout that time my skin was crystal clear. No itty bitty clogged pores, no papules, no white heads. Couldn't have been more perfect. Except for the fact it made me incredibly nauseous in the morning. Also it made me constipated, and whenever I did do a BM it was mushy and watery. It also made me quite bloated. But ever since I was taken off this medicine for those reasons in Dec/15, my skin has been a wreck. I was put on minocycline and it hasn't worked the same. If anything, this is the worst my skin has ever been. I'm thinking about asking my doctor to put me back on sulfamethoxazole and to just suffer through the nausea. What we do for beauty!"

7 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • December 26, 2021

"I have suffered with Acne since I was very young. I was on Accutane for around 4 year’s continually as every time I stopped my acne would return. A few months ago, my acne returned with folliculitis. Tried all the antibiotics in the world and nothing at all cleared it. I didn’t want to return to accutane as I saw a private derm, it was incredibly expensive over the 4 years I spent around £4000+ and the side effects were troublesome. I saw my GP and after I explained my medical history for acne he recommended sulfamethoxazole/Trimethoprim: Honestly, the drug is amazing. I was on 400mg twice daily which was a high dose initially after a month on this dose, I went down to 200mg twice daily. After 2 months, my skin was absolutely spotless. I’d become obsessed with my skin checking it every 10 mins etc… sulfamethoxazole/Trimethoprim is an amazing drug and I would recommend to anyone over accutane."

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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