Semaglutide and Loss Of Appetite: What Users Say (Page 2)

• JRo...
• Taken for 1 to 6 months
• October 29, 2019

Semaglutide for Type 2 Diabetes "Within 2 weeks after moving from the starter dose of Ozempic to 0.25 to 0.5, I began having vomiting in the wee hours of the morning, with increasing intensity, nearly every night for the last 2+ weeks. The last 4-5 have been really rough. I also take metformin 500 and glimepiride 2, both AM and PM. This weekend, I went down to the Ozempic 0.25 dose, but Sunday and Monday nights were both awful bouts of vomiting. (No diarrhea at any stage with Ozempic; occasional nausea during the day, very decreased appetite.) Is anyone else having this bad and persistent vomiting? Thanks and good luck."

• Eda...
• Taken for 1 to 6 months
• February 6, 2020

Semaglutide for Type 2 Diabetes "So I have been on Ozempic for 5 weeks. I am tired a lot. Not sure if this is the drug or my poor sleep, but now that I see others are tired a lot, it makes me wonder. I have nasty burps a lot. I started on a dose of 0.25 for 4 weeks. I had a lot of low-level nausea, but not too bad except for one day. Then last Sunday, I took the higher dose of 0.5, and I was okay on Sunday and Monday, but Tuesday the nausea was horrible, and I had explosive diarrhea all day to the point I had to take Imodium, and I got my doctor's office to prescribe an anti-nausea med, Zofran, which helped a little. The next day, less nausea, and today is Thursday of that week, and I still have the burps and more BMs than I would like, as well as a lot of gas. I know I have lost weight just by how my clothes fit. I have very little appetite. Not sure if the pluses outweigh the minuses yet. I am probably going to try one more week and see how I feel. It has had a modest impact on blood sugars. I have been using less insulin."

• Bai...
• Taken for less than 1 month
• July 3, 2019

Semaglutide for Type 2 Diabetes "At first, I had a brief overwhelming bout of nausea that passed. Decreased appetite definitely had me losing weight, but after the second injection, the nausea got much worse! Plus, I had diarrhea/vomiting, and it just got worse daily. I had to discontinue. Now it's been a month later, and I'm still having nausea and diarrhea. Horrible experience for me."

• Geo...
• Taken for less than 1 month
• February 23, 2022

Semaglutide for Type 2 Diabetes "Been on Rybelsus 3 mg for 16 days. Sugars have improved somewhat already, and weight down about 5 pounds, unexpected. BUT, no appetite, stomach feels full all the time, hard to even drink enough water each day because stomach so uncomfortable. Constipation that is not very responsive to Miralax. Cold hands. Some nausea. More heartburn than usual. Increased fatigue. And the worst is: dizziness and/or vertigo and a feeling of weird fullness in my head along with tinnitus. What the heck? Given the high cost, and that I've all these effects even before going on the 7 mg dosage, I don't think it's worth it."

• Car...
• Taken for less than 1 month
• May 10, 2019

Semaglutide for Type 2 Diabetes "I was put on Ozempic for insulin resistance and PCOS (polycystic ovary syndrome). I take my 3rd dose of 0.25 tomorrow. The 1st week taking it, I had immediate loss of appetite and mild to severe nausea. The struggle with constipation is still ongoing. I would say overall I just felt yucky. Took 2 doses before my body mellowed out and the nausea went away. I find big meals overwhelming now, and I recommend eating healthy snacks more frequently throughout the day (due to loss of appetite). Will up dose to 0.5 in 2 weeks and am nervous that the side effects will return, but hoping not. So far, I have lost 3 lbs, but my weight fluctuates up and down 5 lbs regularly, so not sure yet if it is the Ozempic or not."

• Kay...
• Taken for less than 1 month
• March 11, 2022

Semaglutide for Cardiovascular Risk Reduction "Started Ozempic 0.5 mg a few days ago to help me lose weight, a bit of nausea, and diarrhea, and I lost my appetite for food. I feel it is really working. The only thing is with the side effects, hope they don't get worse."

• Anonymous
• Taken for 1 to 6 months
• January 22, 2022

Semaglutide for Type 2 Diabetes "Started on 0.25 for 4 weeks, then increased to 0.5. Reduced appetite, nausea, constipation, feeling like food just got stuck. I lost over 2 stone. Then started being sick every day, not eating or drinking, every time I did, I was sick. Then I was rushed into the hospital with severe diabetic ketoacidosis. One week after being out of the hospital and recovering, never using this medication ever again. Not worth risking your life."

• 0ct...
• May 24, 2021

Semaglutide for Type 2 Diabetes "I was placed on Ozempic last year because Metformin has always caused awful nausea. I have never in my life had any issue with constipation until I started taking this medication. I was so sick with diarrhea and throwing up 3 weeks ago I thought I'd actually die. I have had bad rashes. I think they would have been worse if I were not on allergy medication. The latest rash is healing. I've never had to take laxatives until this medication. I'd rather deal with the nausea than rashes, vomiting, constipation, poor appetite, and legs feeling strange. I wasn't overweight, so that was not an issue. My numbers have never been more than 6.1. Then, when I read that it can cause death, that was the end all for me. It may help someone, but I'm not the someone! Medicine should make one better, not worse. When I first started this drug, I spoke with someone from the company that makes it about the constipation issue and also my doctor. They said that it would get better, but that hasn't happened."

• San...
• Taken for 1 to 6 months
• December 15, 2022

Semaglutide for Cardiovascular Risk Reduction "My doctor suggested I take Ozempic to bring down my weight and lower my chances of becoming diabetic, which runs in the family. I am 67 and trying to stay healthy. Started a month ago on .25, things were okay, some nausea and decrease in appetite. Started this week on .5 and have been extremely sick, two days in and vomiting frequently. Already have acid reflux, and it is getting worse. The most embarrassing part was today, as I was walking in the street, it just came upon me, and I had to find a corner to vomit on-a horrible experience, to say the least. I want to stick it out and hope it will get better, but I'm not sure I can. My doctor projects a two-month regimen. Hopefully, I can make it, but honestly, if things do not improve on my next dose, I will not be taking it anymore. I question the high out-of-pocket cost for a drug that is causing me so much misery."

• Anonymous
• Taken for 1 to 6 months
• February 11, 2022

Semaglutide for Type 2 Diabetes "Had usual side effects, 3 mg increased appetite and sugar levels. 7 mg nausea, decreased appetite and lost 9 lbs, A1C down to 7.8 from 8.7. On for 3 months and just starting constipation. Next visit, Dr. will up to 14 mg. Will see how that goes…"

• Jef...
• Taken for less than 1 month
• June 26, 2024

Semaglutide for Type 2 Diabetes "Started with a 0.25mg dose once a week. I am on week 3 of taking it and already noticed a decrease in appetite and sporadic increase in feelings of nausea. I also have noticed that I get full quicker resulting in eating less. Bowel movements are no longer consistent and can vary in type. I have noticed that I have moments where I have no energy. In order to try and improve this, I have been drinking a little orange juice. I continue to drink a lot of water since I also take Jardiance, which will dehydrate you if one doesn't drink enough."

• vtn...
• Taken for 1 to 6 months
• May 29, 2024

Semaglutide for Type 2 Diabetes "One month on Rybelsus. Blood sugar levels are down from 150 to 116-96. I have extreme nausea, constipation, and I am unable to eat more than 1-2 cups of food at a meal. I am rarely hungry. Food seems to become lodged in my esophagus and is painful. I have lost 13 lbs. in a month. Fatigue is an issue. My autoimmune retinopathy, which surfaced after cataract surgery, is worse. I fear I will not be able to continue this med."

• mem...
• Taken for 1 to 6 months
• August 11, 2021

Semaglutide for Type 2 Diabetes "I experienced slight stomach issues, mild diarrhea for about 5 days on and off... no nausea or other side effects except a decreased appetite, but after 3 months my hunger has kind of returned. My blood sugar came down about 60 points... on 7 mg so I am not sure what will happen when I go to 14 mg. Overall, this medicine is very good and very, very expensive."

• hal...
• Taken for less than 1 month
• June 4, 2023

Semaglutide for Type 2 Diabetes "The major side effects are all I got with this med, which includes upset stomach, heartburn, burping, gas, bloating, nausea, vomiting, stomach pain, loss of appetite, stomach flu symptoms, headache, dizziness, and tiredness."

• msB...
• Taken for 1 to 2 years
• June 8, 2023

Semaglutide for Type 2 Diabetes "I have been on it for about a year now. So far, I haven't had much in the way of side effects. The only thing I have noticed is some nausea and reduced appetite, especially when I increase the dose. Constipation also has been an issue off and on. I have experienced the bonus of weight loss while on it, losing 27 pounds so far. It has definitely helped my blood sugar, as I have been able to reduce the amount of insulin needed by 6 units so far, and it is rare I need to use any shorter-acting insulin at all. Pleased with my results so far."

• fem...
• Taken for 6 months to 1 year
• September 23, 2023

Semaglutide for Type 2 Diabetes "Serious stomach issues, cramping, bloating, severe constipation, nausea, no appetite, rashes, pain in the upper and lower bowel, gas. Loss of too much weight, no taste for food. Have had previous trouble with colitis and diverticulitis but still prescribed this medication. Only have 1 kidney and now afraid it may be damaged. I have been on this drug for approximately 7-9 months. Now worried, but the doctor is not concerned enough to take me off this medication."

• Pat...
• Taken for 1 to 6 months
• August 29, 2022

Semaglutide for Type 2 Diabetes "I have been taking this drug for about 8 weeks, starting out with the 0.25 dose and now on the 0.5 dose. I have felt miserable the whole time, with nausea similar to pregnancy and with a revulsion to most food and smells of food cooking. Definitely low energy. I have lost weight, and I haven’t had my A1C checked since I started. I will see my doctor in a couple of weeks and will be telling her that I can’t continue to live this way. I’m 75 years young and don’t want to live the rest of my years feeling bad! Unusual, hiccup-type burps, coming out of nowhere and no appetite. Convenient once-a-week administration."

• Her...
• Taken for 1 to 6 months
• April 28, 2021

Semaglutide for Type 2 Diabetes "I am a 54-year-old overweight male who started taking Ozempic 3 months ago to help control my type 2 diabetes and to lower my A1C. For the first 3 weeks, I took a 0.25 dose weekly and felt okay. Some occasional stomach cramps and nausea. For the past 2 months, I have been taking a 0.50 dose, and side effects have gotten worse. Loss of appetite, stomach pains, feeling nauseous, and uncontrollable diarrhea while sleeping. Yes, that's right... I have been pooping the bed. On the plus side, I have lost over 20 lbs, but at quite a disgusting price to pay. Time to either quit taking this or try something else. I now understand the commercials where the people say 'O.' It's because 'O, I pooped my pants again.'"

• Txg...
• Taken for 1 to 6 months
• January 4, 2023

Semaglutide for Type 2 Diabetes "A1c crept up to 6.9. Started Rybelsus for a 30-day intro with fairly vague side effects of light nausea, constipation, and reduced appetite. Increased to regular 7 dosage and immediately side effects were extreme and awful. Constant significant nausea, abdominal discomfort, significant constipation, low energy. Almost no desire to eat, and if I did eat, even very little food caused even more discomfort that escalated. Food just sat in my stomach feeling heavy and sour. Heartburn and gas were constant. After just 5 days of a larger dose, I stopped the medication but with lingering side effects. After being off the drug for two days, I sustained immense abdominal pain like I have NEVER experienced that finally culminated in strange diarrhea. Too many intense and questionable side effects for me. Weight loss - by not being able to eat - not worth the escalating horrible side effects for me. I'll never take this drug again."

• Deb...
• Taken for 1 to 6 months
• January 30, 2025

Semaglutide "I come from a family that has a long line of diabetes. I have an aunt who they just cut three of her toes off and has died just over Christmas from diabetes. I started off with a dose of 50 clicks. I felt sick within hours and had almost a total loss of appetite. So I skipped the next dose. Week three I went back to 40 clicks on the blue pen. Feeling less nausea, I was eating within a window of 6 hours a day. Feeling satisfied and not much for side effects, I went back up to 50 clicks. After one pen, I lost 17 lbs. For pen 2, I varied my days between injections according to my social schedule as it was the Christmas season. I ate whatever I wanted, sweets and everything. And over the next pen, I lost 1 lb a week. So down another 4 lbs. I'm currently 3/4 through my 3rd pen, and I'm holding at 24 lbs."

• Joy...
• Taken for 1 to 6 months
• November 4, 2024

For Weight Loss (Obesity/Overweight) "My side effects are not serious. All that I am experiencing is nausea and loss of appetite. I literally have to force myself to eat and drink. The weight is coming off very slowly, but it's okay. I feel it's more inches than the weight. Hopefully, next month will show more. My dosage is 0.5 mg. It's very easy to use. I give myself my own injections once a week."

• but...
• Taken for 1 to 6 months
• December 2, 2024

Semaglutide for Type 2 Diabetes "No side effects other than loss of appetite and feeling full faster and eating less on lower doses. Good BGL around 100. Once I started 1 mg, I got indigestion, nausea, gas, burping, loose stools, and watery stools. Blamed it on PPI meds for GERD symptoms but continues after I stopped PPI meds. I'm guessing the loose watery stools is the Ozempic at this point. I'm supposed to go to 2 mg weekly but I may not be able to handle it at that dose."

• Ano...
• Taken for 1 to 6 months
• July 30, 2025

For Weight Loss (Obesity/Overweight) "I'm 6 weeks in on semaglutide compound. Started with the 0.25 dose, just went up. I have PCOS and have struggled since I was 18 (38 now). I hovered between 200 pounds all of my 20s and closer to 220 since COVID. I'm semi-active with an office job. I'm not a glutton by any means, but I love a weekend beer and dessert. This medicine was an immediate game changer! After the initial nausea and lack of appetite, it's been smooth sailing. I've lost 1.5-2 pounds a week. I think what really helps is learning what to eat. High protein and fiber are the majority of my diet now. I don't have cravings, I eat fewer portions, and bad foods I'd love before disgust me now. Down 15 pounds in 6 weeks. Over time, tweaking my fiber intake will help with constipation as that is definitely a side effect, but overall, I'm extremely happy! My insurance doesn't cover it, so I'm paying out of pocket."

• Ano...
• Taken for 1 to 6 months
• July 25, 2025

Semaglutide for Cardiovascular Risk Reduction "BP and blood glucose levels are the lowest they have been in a decade while taking 0.25 mg weekly for a month. However, abdominal pain, nausea, loss of appetite, reflux, and loss of energy have been persistent and, at times, debilitating since starting on the drug. Additionally, heart rate is running 15-20 bpm higher constantly. Not sure the gains outweigh the loss of quality of life."

• Anonymous
• Taken for less than 1 month
• January 5, 2024

For Weight Loss (Obesity/Overweight) "I was only able to use 1 injection of semaglutide, the side effects hit me so bad that I couldn’t continue the medication. I got the injection on a Friday, and 2 days later, I had a seizure, which I ended up in the hospital. I had no appetite at all, but the constant headaches and nausea were too much."