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Romosozumab and Tiredness: What Users Say

Brand names: Evenity

Tiredness: mentioned by 6 users (7.4%)

Based on user experiences from 81 Romosozumab reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

pain 18.5%
headaches 16.0%
joint pain 9.9%
fatigue 8.6%
tiredness 7.4%
swelling 6.2%
flu-like symptoms 4.9%
rash 4.9%
body aches 3.7%
soreness 3.7%

Reviews for Romosozumab

Commonly mentioned side effects
  • AGM...
  • Taken for 6 months to 1 year
  • April 14, 2023

For Osteoporosis "I have taken 11 courses of Evenity thus far...and every time I have had pain/swelling/itching at the injection site, headaches, body aches, lethargy, and trouble sleeping in the days following the injection...though admittedly, the ill effects are not as severe now as in the early days of the treatment. However, I am concerned about the long-term after-effects, mostly issues with my teeth/jawbone. While I have been closely monitored by my dentist and all appears well thus far, it's still a worry. And too, the potential for bone build/improvement is minimal at best--10% according to my doctor. Seems like a lot of misery to go through for such a little bit of potential improvement. My doctor also recommended I move to another injectable medication once I finish with Evenity, but they ALL carry the same terrible potential risks, so I declined. I hope to have some bone density improvement, but honestly, I do not expect much."

3 / 10
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  • Mar...
  • October 27, 2023

For Osteoporosis "Last August, I completed 12 months of Evenity treatment. I had very mild side effects only on the day after each series of shots, a mild headache and a little tired, injection sites (each arm) sore and tender for a week. But completely tolerable. After 2 spinal compression fractures and 3 years of Reclast, I welcomed each Evenity shot! No new fractures, so that’s worth celebrating! My endo also got me into a program that paid for the drug copays."

9 / 10
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  • cal...
  • Taken for 6 months to 1 year
  • October 23, 2022

For Osteoporosis "Heading toward my tenth Evenity injection this month (end of Oct. '22). No problems. An easy injection process by my Dr. Had a little joint pain at the outset, but nothing of any consequence. Blood tests have been fine. Vit D and calcium levels normal. Perhaps a little tiredness at times could be attributed to the drug. I will see with my bone density score at the end of the process if it was all worth it. I hope so."

7 / 10
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62 Report

Frequently asked questions

  • wor...
  • Taken for 6 months to 1 year
  • March 26, 2025

For Osteoporosis "I really didn't want to be on this drug; however, my last bone density scan (at age 70) showed significant adverse changes compared to the prior two years (-3.2 spine). This was despite taking Vitamin D, Calcium, doing Pilates, tennis, yogalates. I felt I had no choice but to go forward. I have now completed 12 months of injections (2 shots every 4 weeks). The first month or two, I felt tired and headachey the day of and the morning after the injections. However, for the most part, I am relieved to say that I had no side effects. I don't know my bone density yet as I'm not scheduled for another scan until next year. I had the injections in my stomach because I have a bit of fat there. The shots are somewhat painful, but taking them in the fat area of my stomach didn't cause too much pain. My doctor now wants me to start Reclast. He believes my bone density is improved but may regress without continued treatment. Cross fingers with Reclast."

8 / 10
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  • Kar...
  • Taken for 1 to 2 years
  • February 2, 2025

For Osteoporosis "After reading several negative reviews, I was nervous to begin Evenity in January 2024, but was pleasantly surprised with pretty much no side effects. The shots do hurt/burn, but that only lasts a few seconds. I took Tylenol and drank plenty of water on the day of my injections and felt fine except for being very tired. I took afternoon naps, and by the next day, I felt completely normal. My bone density increased by 9.1% in the lumbar spine and 7.9% in the femoral neck. Still classified as osteopenia, but I am happy there has been some improvement. I will be starting Reclast infusions next month."

10 / 10
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  • Deb...
  • Taken for 1 to 6 months
  • March 6, 2023

For Osteoporosis "I have taken this for 6 months now, and my bone scan scores have improved. However, it is making me very tired, which is leaving me a little depressed."

5 / 10
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47 Report

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