Romosozumab and Fatigue: What Users Say

• Hug...
• Taken for 1 to 6 months
• February 13, 2023

For Osteoporosis "I am 68. I took my first Evenity shots in October 2022 and my last in December 2022. Since October, I have had dyspnea, dizziness, and lightheadedness. I can hardly be in a store for more than 10 minutes without feeling as if I will faint. Because of fatigue and weakness, household tasks are difficult. I move much more slowly. Now with dysphagia and anorexia, eating is difficult. Although never painful before, the joints in my hands, fingers, and toes are stiff and painful. Additionally, I developed cramping in those areas. The pain in my hips, upper thighs, neck, and shoulders is poorly responsive to all pain medications. There was an exacerbation of pain in several old areas of injury which had not been painful for decades. And now I have intermittent pain in my eyes and an annoying twitch in one that will not subside. After that first shot, it was as if someone flipped on a switch with all these symptoms. My concern is they will not go away for a long time, if ever. Evenity was a huge mistake!"

• Tom...
• Taken for 1 to 6 months
• March 20, 2023

For Osteoporosis "I took Evenity after an endocrinologist, with my immunologist’s blessing, decided it would help with osteoporosis after a hip stress fracture. It was the worst decision to listen to them, it’s poison! I felt sick after the first shot but wasn’t sure if it was the flu or not, so I continued taking it. After the second shot, I started experiencing diarrhea and swelling in my throat and mouth. By the third shot, my jaw started twitching and moving on its own. My upper and lower back teeth hurt, and I was biting my mouth, tongue, and cheeks while eating and even during the night. I also had headaches, continued flu-like symptoms, added fatigue, insomnia, and an overall feeling of being unwell. I finally stopped taking Evenity after the sixth shot, even though it was prescribed for 12 months. Now, I have a twisted jaw where my teeth no longer match up, and I can only eat using the teeth on my left side, which is horrible. The doctor prescribing it and my primary care physician never mentioned these horrible side effects in their notes. I saw an orthodontist, and my bite is completely off."

• Shr...
• Taken for 6 months to 1 year
• February 10, 2023

For Osteoporosis "Just completed round #9 of 12 injections. Things potential patients should know: 1) The injections are painful...think cortisone joint injection painful, but not quite. 2) Expect post-injection swelling, sensitivity, itching, etc. 3) Expect to have some degree of generalized malaise in the days following your injections. After the first round, I, personally, felt like I had the flu...minus any fever, nausea, or vomiting. Severe headache and body aches. Subsequent injections brought similar after-effects, though to a somewhat lesser degree. With every visit, you are asked the same questions about your general health-any new/planned dental surgery (osteonecrosis of the jawbone), stroke/heart attack, serious illness, or infection which makes me more than a little concerned about the long-lasting negative impacts on my health. At my most recent visit with the doctor, he indicated the best bone density improvement will only be about 10%. In my opinion, that's not much considering all the pain and misery I feel while taking it."

• cal...
• Taken for 6 months to 1 year
• October 29, 2022

For Osteoporosis "I had my 10th Evenity injection on Oct 26th. Two more to go. I had very little in side effects throughout the past 10 months of injections. Some slight joint pain in wrists and some fatigue on occasion. Took blood tests every 3 months. Vitamin D and calcium levels remained steady and normal. I will see how much success in bone density improvement occurred in January 2023 when I will take my next density test. But as it stands today, I have had no problems with this drug."

• Deb...
• Taken for 1 to 6 months
• December 21, 2024

For Osteoporosis "My injections started last month. First 3 days, I felt fine. Day 4, I felt very achy, flu-like symptoms, extreme fatigue; for a week, I wondered why I agreed to this treatment. I informed my endocrinologist. At Dr. suggestion, 2nd dose this month, I drank 2 eight oz glasses of water before injections. This is day 5; I still feel great. I'm fatigued, though not as intense; it might be from other factors, such as stress or just getting older. I’d tried Fosamax; it bothered my tummy. I’ve never tried Prolia, but its side effects sounded scary. I’m committed to 10 more Evenity injections, with hopes of success. I walk (sometimes wearing a weighted vest 10#), lift weights daily, and use the gym's Power Plate, which supposedly increases bone mass. I do yoga. My diet is calcium-rich, and I use calcium/D3/K2 supplements. I get outside daily, even if it's chilly out. I avoid caffeine and alcohol."

• Ano...
• Taken for 1 to 6 months
• May 28, 2025

For Osteoporosis "I just had my 4th Evenity injection. I had my 3rd injection in my arm, and it swelled up like a large (egg shape and size) hematoma. It stayed red and swollen for a few days. I went back to the tummy site. No pain with the injections. I am fatigued and feel out of sorts. I tried Reclast, and it was a bad experience with it. I’ll go back to Prolia after my last shot. I’ve used that in the past and had no issues."

• La...
• Taken for 1 to 6 months
• July 24, 2024

For Osteoporosis "I am getting my 3rd Evenity treatment next week. I am happy I am able to receive this drug. The side effects have been very tolerable- a bit fatigued after the first injections. I thought the injections would be more painful, they are not."

• Ter...
• Taken for 1 to 2 years
• October 28, 2024

For Osteoporosis "The first three infusions by arm swelled up at the injection site and were bright red. Then my ankles, up to about midcalf, swelled up as well. I have some ankle swelling that now has not gone down. That was a result of the injections. I also had fatigue the first three months after the injections, but after that, it subsided."