Rimegepant and Nausea: What Users Say

• Ms ...
• Taken for less than 1 month
• August 3, 2020

For Migraine "Within 20 minutes of taking Nurtec ODT, I had the nausea, which I had read about. I took some Zofran, but it didn’t even touch it. Then I had diarrhea and horrible stomach pain, as well as really intense reflux. It felt like I was swallowing fire, 17 hours and counting now. The worst part of this is my migraine isn’t even all the way gone! It is definitely diminished but not gone. I have never written a review on here, but this has been such an awful reaction I knew I had to. I will never take this again. Everyone is different, but for me, this has been a really terrible experience."

• Ver...
• Taken for 1 to 6 months
• January 14, 2021

For Migraine "I have had migraines for 30 years and hemiplegic migraines for about 10 years. I've taken just about all migraine prevention meds and usually use Imitrex injection to get rid of migraines, but because I recently started having breathing and heart racing with Imitrex, I tried Nurtec again. First, second, third time intense nausea and vomiting. Now 4th time, migraine pain spread to both eyes and is getting worse. I've been on Aimovig, Emgality, and now Ajovy with no results. Botox caused migrainous syndrome, and I ended up with a paralyzed neck. I am sadly disappointed in all CGRP meds, including Ubrelvy."

• DrB...
• Taken for 6 months to 1 year
• October 10, 2020

For Migraine "This is the only drug that's actually worked for my chronic migraines. I also use neurobotox as a preventative, but it hasn't been preventing much lately. I get occipital migraines that last 3 days constantly. They come with nausea and hypersensitivity to light and computer screens, which is debilitating since I work in an office setting. I started Nurtec in February and it's saving my life right now. One pill lasts 2 days, and it destroys the migraine and the nausea. It always takes 40-45 minutes to kick in. My migraines tend to come on in the night, so as soon as I wake up with one, I take a Nurtec and wake feeling better. These are keeping me functional since my migraines have been so much worse this year."

• CJ-...
• Taken for less than 1 month
• July 19, 2020

For Migraine "I had a bad experience with Nurtec. After one dose, Nurtec caused severe nausea which started about 15 minutes after the pill dissolved. The nausea was the worst I have ever experienced, and it lasted for about 18 hours. The nausea was so severe that I was unable to function for the entire time. The nausea led to vomiting, which lasted 2 hours, but it didn't relieve the nausea. Zofran also did not relieve the nausea, and then my doctor called in Reglan, which seemed to help. Nausea is a known side effect of Nurtec, but I certainly do not think anyone would expect this kind of toxic reaction. Be careful with this medication."

• Lal...
• Taken for less than 1 month
• May 5, 2021

For Migraine "My neurologist gave me this to try as an abortive medication along with one other to compare. The other was Ubrelvy. So I took this one when I had a migraine, and I noticed immediately it made my stomach queasy. It didn't last, so that was good, but I was dizzy. I had a slight case of vertigo. When I went to lay down, I started kind of spinning. I was trying to wait it out and fall asleep, but I just felt weird. But my head did start to feel better. But now I am in a haze and don't think I can go to work or do anything around the house. I just feel like I have the flu. I don't like this feeling. I think I preferred the other medication because I didn't experience these side effects."

• Pun...
• December 6, 2020

For Migraine "I was very hopeful Nurtec ODT would be an effective addition to the Botox for treatments I already receive. As I have been a migraine sufferer since childhood and have had minimal relief. Unfortunately, I experienced more side effects than what are listed. One hour after taking it, I developed slight nausea with significant reflux. I was delayed, light-headed, under the influence, and could hear/feel my heartbeat loudly. I took it during my workday and had to get a ride home since I did not feel clear enough to drive myself. My headache remained and I felt so “stoned” that I went to bed at 8 pm and slept solid until 4 am. I awoke still with a headache, but no longer stoned. I spoke with my neurologist and explained my experience. He has advised me to discontinue use. I feel they should include a warning not to “drive or operate heavy machinery until you know how it affects you.”"

• sal...
• Taken for less than 1 month
• March 20, 2021

For Migraine "First of all, I tried it once and NEVER again. I am allergic to peppermint, and nobody told me it was peppermint flavored. This causes automatic vomiting and nausea! I ate some Jell-O just to try to keep it down. It did not work, made me severely dizzy and nauseated, woozy, and I really thought I was going to just faint. It was horrible. NEVER again."

• A01...
• Taken for 1 to 6 months
• May 20, 2021

For Migraine "Every time I took Nurtec, the strong mint taste made me nauseated. It took 4-6 hours to work and made me feel super sleepy. My migraines treated with Nurtec frequently came back later that day, and I had to wait 24 hours after the first dose to take another. My neurologist switched me to 100 mg Ubrelvy, and I find it works much better and faster."

• Bun...
• Taken for less than 1 month
• August 30, 2020

For Migraine "I have had chronic migraines for years, and I was excited for a new medication. My excitement was quickly dashed. A few minutes after taking Nurtec, I became nauseous, and after 4 hours, it hasn’t helped my migraine at all. I will try it again, but my hopes are being dashed."

• Nau...
• July 23, 2022

For Migraine "I just took it yesterday for the first time, which the dissolvable tablet was disgusting. It's been 27 hours since I took it, and I keep getting severe waves of nausea. It feels just like motion sickness, and I'd be fine if it just gave me diarrhea, but it's vomiting this nausea gives me. I will get a hot flash and get dizzy when looking at screens, smoke a cigarette, or even go in warm weather. The nausea is an 8/10 and is similar to when my ear was filled with fluid and I was dizzy. Wondering how much longer this nausea will last just from the one pill."

• Ala...
• Taken for less than 1 month
• May 29, 2021

For Migraine "I get hormonal headaches near my time of the month. They come on at night and can last several days. They usually start in my temples and involve neck stiffness. On day one, I took two rizatriptan, and it just made me nauseated and exhausted with no relief. On day two, I decided to give my Nurtec sample a test run. My headache was gone in an hour and hasn’t come back yet. I’m not groggy at all and I haven’t noticed any GI side effects. I haven’t really had any major side effects. Not sure if it’s just PMS, but my shoulders and hands are a little fatigued, but not enough to bother me."

• Bre...
• September 17, 2020

For Migraine "Yesterday was my first time taking Nurtec ODT (that 2-dose sample pack), so I set a timer to track when (if) relief and/or side effects kicked in. 10 minutes after taking it, I almost threw up into the trash can in my office. I took 2 Zofran (for nausea), and they brought me from gagging to queasy enough to be miserable but not enough to be physically sick. There was some relief from the migraine itself about 30 more minutes later; the heavy throbbing in my head came down to an ache instead. I still received all the same sharp stabbing pains, though. At about 4-5 hours later, my headache was completely gone, though that long after the fact I question if it was the medicine or not. I've just taken the 2nd dose now, chasing it immediately with my Zofran instead of waiting and eating starlight peppermints to try to control the nausea. We'll see how it does this 2nd dose. Overall, I highly doubt I'll get my GP to write an actual prescription for this, even with the discount card to counter the costs."

• Kkc...
• Taken for less than 1 month
• October 7, 2020

For Migraine "First time I took Nurtec ODT, I had nausea. Second, no nausea. Worked both times. However, I have developed bilateral leg swelling, mostly on my thighs and knees. I am only 43 and have never had this happen before. I am scared it has done damage. I won’t take again."

• Rob...
• Taken for less than 1 month
• August 3, 2022

For Migraine Prevention "Within a few doses (was taking it every other day) caused brain fog, dizziness, nausea, and felt a tightness in my head. While it did stop a migraine in about 1 1/2 hours, I only started it on 7/20/2022. At the doctor's suggestion, I tried again, and on Monday, 8/01/2022, I had worse of the same symptoms. Have not and will not take another dose, but it is now Wednesday, 8/03/2022, and I still feel not just the brain fog but the tightness in my head and feel like I'm on sleeping pills. Left another message for the doctor. I WILL NOT take this medication again. Causing more health issues than just having migraines."

• Nau...
• Taken for less than 1 month
• March 24, 2023

For Migraine Prevention "I had terrible nausea with this medication. It lasted all day, every day, and I was unable to do anything due to the extreme nausea. I rarely went to work. Nothing helped. Without medications, I have migraines every day. This medication did not take the migraines away. I did not try it during a migraine, though. But it is definitely not a preventative medication for people with chronic, everyday migraines. When I took the pill, within an hour, I was afraid that I was having a heart attack. It felt like an elephant was sitting on my chest for about one hour. I continued to take this medication for about 10 days, hoping that these reactions would go away after I got used to the medication. I finally had to stop taking it. It took about one month for the side effects to go away. It was miserable! And unfortunately, it never helped with my migraines. However, we all know that as a migraine sufferer, one will try anything to make the pain stop."

• HK7...
• Taken for less than 1 month
• March 24, 2022

For Migraine "I took Nurtec for the first time yesterday, on my second day of a migraine at 2 pm. I first felt pins and needles all over. My headache did go away after 30 minutes. However, an hour later, it returned with a vengeance, along with nausea and blurred vision. It’s now 7 pm the following day, and I still have what feels like a rebound headache, and my vision is still blurry. I will not be using Nurtec again and will continue seeking relief through hopefully more natural solutions—instead of all these medications with unbearable side effects."

• Blu...
• October 17, 2020

For Migraine "Nurtec ODT does not work on Excedrin rebound/medication overuse headaches. I took one Nurtec ODT 12 hours ago, and it maybe dented the pain slightly, temporarily. No nausea. I either have a migraine, a headache, or an Excedrin rebound headache. The over-the-counter (OTC) pain reliever Excedrin combines caffeine 65 mg/caplet, aspirin 250 mg/caplet, and acetaminophen 250 mg/caplet. My habit is currently 3 Excedrin per day. I take an Aimovig shot 1x per month, which helped the first 2 months with many Excedrin and pain-free days. I took Imitrex 2x in 24 hrs yesterday, and it reduced the pain level and put me to sleep but did not work very long. When I could feel the Imitrex wearing off, I took the Nurtec. Nurtec, Aimovig, and Imitrex, and the migraine is still there. My doctor gave this to me to stop the rebound, but it has failed on rebound duty."

• Anonymous
• Taken for 1 to 6 months
• March 20, 2025

For Migraine "I am a 50-year-old female who has struggled with 72-hour migraine episodes, several times a month, for the past six years. I have had all sorts of inconclusive testing, tried numerous medications, none of which worked. I am writing this review in the hopes that it may be helpful to others. The first time I took Nurtec, I had unimaginable nausea, and it barely helped with my migraine. I didn’t think I’d ever try it again, but I did because when another migraine came, I didn’t have anything else, plus I had to go through so many hoops to get my insurance to approve this expensive medication, I suppose I felt like I owed Nurtec another chance. I’m glad I did! Each time thereafter, my negative side effects lessened until they disappeared altogether. If I take it the moment I feel a migraine coming on, I can pretty much prevent it entirely. If I’m in denial and wait to take it, it usually takes about 4 hours to eradicate my migraine."

• AJD...
• Taken for 2 to 5 years
• October 22, 2024

For Migraine Prevention "I’ve had migraines since I was a kid. They’ve continued to worsen with age. Most months, I was experiencing 23-25 days with severe migraine with aura, light sensitivity, nausea, aching body, stomach upset, sensitivity to smell and sound, dizziness, numbness in my face, and horrific stabbing pain on the left side of my head. I tried everything, including chiropractic treatment, antidepressants, exercise, topiramate, ice, hormones, magnesium, B vitamins, etc. Nurtec as a preventative has been a godsend. It gave me my life back. Now I just have to fight with insurance every so often to keep it. I have maybe two migraines a month now, and they’re nothing at all like they were. So thankful."

• Pai...
• Taken for less than 1 month
• March 15, 2025

For Migraine "I recently tried Nurtec ODT (rimegepant) for my migraines, and while it did relieve my migraine, the side effects made it difficult to justify taking it again. I want to share my experience to help others decide if it’s the right option for them. 1. Effective Migraine Relief I’ll give Nurtec credit where it’s due—it worked for my migraine. Within about 1-2 hours, the pain significantly reduced, and I was able to function again. The relief lasted for over a day, which was impressive. 2. Severe Nausea & Stomach Pain The downside? The nausea hit me hard. Shortly after taking it, I felt waves of stomach discomfort and queasiness that lasted for hours. I tried taking it with food, but it didn’t seem to help much. The stomach pain made it difficult to enjoy the relief from my migraine. 3. Lingering Fatigue Even after the nausea faded, I felt drained and sluggish for the rest of the day. It was almost like a migraine hangover."

• Anonymous
• Taken for less than 1 month
• October 7, 2022

For Migraine "I've taken several types of triptans, and sometimes they take the edge off, or if I take them very early in the day, by night I might be feeling a bit better, able to sit on the couch with my kids-but still no normal function. So I thought I'd try Nurtec because of the hype and recommendations. This was definitely not for me. I felt drugged up. I was bursting into tears, acting weird, asked my sister to pull over to the side of the expressway because I thought I was going to vomit while she was getting me home (it was a sudden urge rather than general nausea). And then I was in a 'haze' for a couple of days. It's definitely not something that I ever want in my system again. I'm a slimmer woman and also wonder why the same doses are given across the board. I'm definitely sticking with my triptans (Frova, Nara)."

• Sar...
• January 29, 2023

For Migraine "I wanted to leave a review since I figured most people who bother to leave one only do so when they have a negative experience. So for those of you who rely on reviews to make your decisions as I do, I just wanted to leave my own experience. I tried my first Nurtec today after avoiding it for a while out of fear that I’d have a negative reaction. I wish I had taken it before during my last two migraines because the only side effect I had was VERY mild dizziness. So mild that I could shower and walk around and feel fine. Other than that, no nausea, no stomach pain, nothing. My headache is gone and I feel completely fine. So grateful for this medication!"

• Mic...
• March 15, 2021

For Migraine "My doctor ordered me the Kyleena IUD for heavy bleeding. I started having awful migraines several months after it was inserted. My doctor said hormones are 99% responsible for migraines. I started to take Imitrex and was a zombie on it and had to go to bed. I went to my neurologist and he prescribed Nurtec ODT. When my first migraine hit, I was in excruciating pain, and the box was extremely difficult to open. I tried to open it, but being in that much pain made it even harder. Once the package was opened after 5 minutes of trying, it started to work in 30-40 minutes. I have never had a migraine leave so quickly. I was not nauseous or even tired after it worked, and I basically could go back to my normal daily routine. It is a huge blessing that I live in this day and time that we have drugs like this one available to us!"

• Anonymous
• Taken for less than 1 month
• December 16, 2022

For Migraine "I just read in the comments this contains sucralose! I'm extremely allergic, and my doctor knows about this but prescribed it anyways as a rescue medication. I've been bedridden for almost 6 days and went to take it again. Good thing I looked at these reviews. If you have an artificial sweetener intolerance, don't take it. I haven't been able to move, vomiting, nausea, increased pain, etc."

• bun...
• December 19, 2022

For Migraine "So right off, I was afraid it was gonna taste bad. It didn't taste bad, it was minty, but it did leave a really strong aftertaste, like metallic or bitter. It made me feel really weird, like whooshy. And I felt like I was talking really slowly. And I stuttered a lot. I felt really floaty, and I had a hard time walking. And the nausea was so bad. Worse than migraine nausea. Like I was salivating like I was going to throw up. But I didn't. My tongue also felt really weird, and I did look in the mirror to see if it was swollen, it wasn't, it just felt weird, like numb. And I ate a little piece of fudge. It tasted like pure butt. In fact, everything tasted bad. Even water. And I still had a migraine. It didn't progress any further, pain-wise. Just like it was at a standstill. So I took it around 12:30 pm in the afternoon. And the migraine finally disappeared around bedtime, about 10:30. So the only thing it really did was stop the migraine from progressing to further pain."