Motegrity for Chronic Idiopathic Constipation User Reviews (Page 3)

• Liz...
• Taken for 1 to 2 years
• March 6, 2022

"In 2020, I was hospitalized for an intestinal blockage. At that time, they did not want to do surgery because it was a functional issue, so the protocol was NPO for several days. After I left the hospital, they put me on Motegrity 2 mg once a day. I’ve taken it for two years, and I’ve gained over 25 pounds. It does work in the beginning for motility, but then after a year it stopped really working. I don’t know why I bothered staying on it for as long as I did because the only thing that wound up happening is getting a tremendous amount of weight and becoming depressed from it."

• SAM...
• Taken for less than 1 month
• April 9, 2024

"I'm on day 3 and so far it works great. Linzess and Trulance worked a week and stopped, so the jury is out for the long term. The only side effects I have experienced are mild dizziness and back pain. And one strange one, which may be the cause of the loss of appetite. Things that should not taste salty do. That started today. Grapes, French toast so far. I hope that goes away with time."

• sun...
• Taken for 1 to 6 months
• January 1, 2022

"I was originally given Motegrity without trying the others because I had been following all the lifestyle advice typically given to start off. I had printouts of my daily meals, water consumption, fiber intake, macros. I was also already on a modified diet to avoid allergens. (I like data.) And it was clear movement for water like Linzess wasn’t going to do it. The first two months, I had to take it with Miralax, 1000 mg of magnesium, and senna at 8.6 mg? It took all four to go. I went every day, but it was explosive and miserable. So she reduced it down to 1 mg, and now things are manageable (every two days ish), but I’m constantly boiling. Y’all, I’m not at menopause age yet. I shouldn’t be sweating like this. But I’ve been in undershirts in 50-degree weather, and I sweat enough to completely stink in a few hours. I also regained all the sudden weight I lost prior to Motegrity in about two months (50 lbs, about 1/4 of my body). I'm also queasy all the time."

• Dot...
• February 5, 2021

"I have been on Motegrity for over a year, and it worked great for a while, lately, I have had problems with feeling jittery, anxious, and depressed. Feeling jittery and anxious is the worst. I have gastroparesis and am also on Famotidine, Promethazine, Lansoprazole, and Motilium, so it may be a combination or the Motegrity."

• San...
• Taken for less than 1 month
• February 10, 2021

"After suddenly developing abdominal pain and infrequent BMs four years ago without consistent relief from diet changes or OTC products, or Amitiza and Linzess, I'm trying this (and one other which is less effective). This "worked" initially with soft and loose stool, lots of gas, and cramping. Added my OTC again, but ineffective. Tried the other sample drug, even less effective. Back on Motegrity, same experience and have concluded it's exacerbating neck and back pain to intolerable levels, possible wrist and ankle pain, fatigue, and the blues. Totally interfering with sleep. The only temporary relief I get is swimming or exercising."

• Tif...
• Taken for less than 1 month
• February 17, 2022

"I was on Linzess for several months. It completely took away the abdominal pain, and for several weeks, I had severe diarrhea. Then, it settled down, and things seemed to improve, but a month later, I was having maybe 1 bowel movement a month. I switched to Motegrity, it's been 2 weeks of misery. Headaches every day, abdominal pain, and bowel movements are more frequent but painful. I'm so disappointed. I will stick it out for a while longer and hope it improves."

• Ati...
• Taken for less than 1 month
• December 27, 2020

"Worked for 3 days and then back to constipation. Also seemed to not mix well with my anti-seizure drugs. My previous seizure drug had caused a particular type of seizure and depression. I haven't had those problems since I switched off that drug, but experienced both in the past week, so I am going to discontinue use."

• Deb...
• Taken for less than 1 month
• November 3, 2024

"I have suffered with chronic constipation my entire life. I'm currently sixty-eight years old. After trying to deal with it myself and trying every laxative there is on the market, changing my diet, etc., nothing worked. As a last resort, and trying Linzess and Amatiza, my gastro doctor put me on Motegrity. She was determined to help me, especially since my colonoscopy was not clear enough to get a result. I have to say, after a week, I go every single day. However, the one side effect that is starting to affect me is terrible gas pains that wake me up in the middle of the night and last an hour or more. I'm hoping this is temporary and it will subside after another week or so."

• kal...
• Taken for 1 to 6 months
• April 7, 2023

"I have gastroparesis and have been taking Motegrity for two months now. I'm not really sure how it's supposed to work, I thought it would help relieve constipation and make it easier to go to the bathroom. I am suffering for up to 4 days not being able to have a bowel movement. My doctor thinks that I might have a lot of toxicity in my stomach, and I have to take a breathing test. I also suffer from headaches and did not realize until I read all the posts that headaches are common with this."

• Ann...
• Taken for less than 1 month
• May 16, 2023

"I wanted to share my story as I just took my first dose of this medication tonight. I'm crossing my fingers because nothing else has been effective, and I am currently down to 107 pounds at a height of 5'5". During the lockdown, I was exposed to toxins in a home I had recently moved into. After four months of being there, I experienced a wide range of symptoms, including severe gastric emptying delay and dysfunction in my colon. Whenever I eat, I suffer from severe consequences. At the moment, I'm on my third round of Xifaxan, which costs $2500 for each two-week treatment, and my gastroenterologist suspects it might be small intestinal bacterial overgrowth (SIBO) as well. Xifaxan helps with reducing inflammation and bloating, but unfortunately, my colon isn't improving. Currently, the only thing I am able to eat without major issues is eggs, and even then, I have to use a daily enema. I also have eosinophilic esophagitis (EOE) and have undergone several surgeries involving scopes, biopsies of the esophageal area, and laparoscopic exploratory surgery. As I enter my third year with these conditions, they are getting worse."

• Sha...
• December 28, 2019

"I have experienced constipation for many years. I take Motegrity along with a magnesium supplement every day. (Not at the same time) No side effects for me. I’m finally normal. Thank you, Motegrity."

• Cur...
• Taken for 6 months to 1 year
• February 20, 2024

"Relieved my constipation. Am going daily now when I used to only go once a week. Changed my life."

• Anonymous
• Taken for less than 1 month
• February 26, 2022

"I have taken it 3 times, and each time the same side effects, all within 15 minutes of taking the medication. Bloating was the worst, along with stomach ache, nausea, and severe headache!! No thanks."

• Reb...
• Taken for less than 1 month
• December 23, 2021

"Doesn't work! I have extremely slow-moving bowels, and absolutely nothing works. I had high hopes for this! I have had no side effects at all, but it just doesn't work. Day 6 and nothing."

• Mar...
• Taken for 1 to 6 months
• March 9, 2022

"3 months of 2 mg. Plus Miralax 2 x daily. Stool very soft, never empty enough for colonoscopy."