Skip to main content

Adipex-P and Headaches: What Users Say

Headaches: mentioned by 47 users (7.7%)

Based on user experiences from 609 Adipex-P reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dry mouth 27.3%
headaches 7.7%
insomnia 7.4%
tremors 4.3%
increased heart rate 4.1%
loss of appetite 3.4%
anxiety 3.0%
constipation 2.8%
nausea 2.6%
dizziness 2.5%

Reviews for Adipex-P

Commonly mentioned side effects
  • She...
  • February 11, 2020

For Weight Loss (Obesity/Overweight) "Started Adipex 11 days ago, weighed myself today and have lost 11 pounds. Started at 181 and am now 170. Going through menopause and have spent the last two years in the gym unable to lose a pound. Once menopause hit, I gained so much that my BMI for the first time put me in an overweight category. I asked my Dr. if there was something I could take that helped the work that I already do actually work. Goal weight is only 155, I'm 5 feet 10 inches tall. The first week she had me take half a pill a day, beginning of second week a full pill. The first day I had a bad headache. I have dry mouth from taking it, but not so bad it's unbearable. I drink a ton of water. It took away my desire to drink coffee and it never gave me the bad coffee withdrawal headaches. I'm eating anywhere from 600-1200 calories. Change your eating habits while on Adipex. Take those few months to get your body adjusted to healthy food choices so that it doesn't crave the bad stuff once you're done taking the pills."

10 / 10
Was this helpful?YesNo
634 Report
  • Fra...
  • Taken for 1 to 2 years
  • November 25, 2014

For Weight Loss (Obesity/Overweight) "Adipex-P worked for me. I lost the weight and I'm keeping it off. I haven't become resistant to the medicine at all. The generic brand is different - I had a headache and dry mouth. The name brand - no problems. I'm continuing to take it under the supervision of my doctor. I have no side effects, I feel good and I'm at a good weight. I exercise and stay on a low carb/high protein diet. This medicine rescued me from the weight loss merry-go-round."

10 / 10
Was this helpful?YesNo
190 Report
  • Cor...
  • July 16, 2019

For Weight Loss (Obesity/Overweight) "I am 44 years old and I was 182 pounds 3 months ago. I started diet by myself and I was able to lose 10 pounds. I went down to 172. Then I got stuck. I finally went to my doctor and he prescribed me the Adipex pill. I started last Thursday at 172.5 pounds, exactly 6 days later I am down to 166.6, and it's not even a week yet. I will keep you posted. As for side effects, only the first 2 days I had a light headache, but I am okay now, I am very thirsty. I started walking every day for at least 35 minutes. I still have a problem with my foot, so I go very slowly, but I am trying. So far, I love it. I am not hungry, and I am very careful about what I eat. I eat vegetables, fruits, lots of water, and fish. Sometimes a small piece of grilled chicken. I forget to eat, but I am trying to eat in between veggies or fruits because I don't want to gain all the pounds back once I stop the medication. I will take it for 3 months, so I still have a long way to go. I need to go down to 130, 36.6 pounds to lose."

10 / 10
Was this helpful?YesNo
91 Report

Frequently asked questions

  • Mad...
  • August 15, 2016

For Weight Loss (Obesity/Overweight) "I was on Adipex in 2010. I started out at 272 lbs. I was amazed at how much weight I lost every week. I had to buy new pants, jeans, etc. every week. I averaged 8-12 lbs lost per week. I lost 126 lbs in just under 5 months. I was very active, exercised every day, and didn't have the craving for food. I did find that not eating led to headaches and mood changes. You have to eat!"

10 / 10
Was this helpful?YesNo
115 Report
  • ked...
  • Taken for 1 to 6 months
  • March 25, 2015

For Weight Loss (Obesity/Overweight) "This pill works! I do advise that you eat breakfast, wait 30 mins, and drink water throughout the day. If you don't get hungry, eat something wholesome. My experience with headache and mood swings was due to me not feeling hungry, yet my body still needed fuel. Listen to your body! I'm at a weight that I'm happy with. I do exercise, it's my therapy. One seventy-three from 205! Also, it helps with my blood pressure. Eating is so much easier. I can think about what I need to prepare versus just grabbing the first snack, not so good choice that would satisfy me. Know your body, breathe, don't overthink, be happy. This is coming from me! It helped along with small positive changes. Peace!"

10 / 10
Was this helpful?YesNo
120 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • nik...
  • Taken for less than 1 month
  • July 25, 2013

For Weight Loss (Obesity/Overweight) "Started taking the pills on Saturday. By Tuesday, I was down four lbs. My first three days, I felt lightheaded and had headaches at night. I love this medicine, I have no desire to eat. Now I can finally get rid of the carbs, and by my third month, I hope I never go back to them."

10 / 10
Was this helpful?YesNo
90 Report
  • EEa...
  • Taken for less than 1 month
  • November 17, 2016

For Weight Loss (Obesity/Overweight) "I started Adipex on 11/14/16. My starting weight was 310, weight today is 301. It's day 4, I weighed in yesterday and lost 9 lbs. I don't seem to have more energy, but it does work. The only side effects I have are dry mouth and a slight headache. I have absolutely no appetite and have to force myself to eat, but I also have no desire to drink sodas or any junk food, which is a great thing. I love this pill and would recommend it."

10 / 10
Was this helpful?YesNo
67 Report
  • MKm...
  • Taken for 1 to 6 months
  • May 17, 2016

For Weight Loss (Obesity/Overweight) "Been on generic Adipex for 1 month. Start weight 183. Current weight 171. Drink lots of water on this. Dehydration can cause headaches (I get migraines already, so this did not increase due to the medication). The first day I was nauseous. The first week was extreme dry mouth and complete lack of appetite. I had to remind myself to eat during the first week. At some point during the second week, I was feeling a bit hungry but not the constant hunger I experienced before. As of the end of the first month, the only persisting side effect is the dry mouth. I'm also not sleeping very well! But I just take Tylenol PM for that. Overall, I feel good. I'm losing weight. I'm less hungry, so I'm selecting better food choices. (Chocoholic lol) and no serious issues."

10 / 10
Was this helpful?YesNo
62 Report
  • Aw4...
  • May 5, 2016

For Weight Loss (Obesity/Overweight) "I am 5'3, and when I started Adipex in late January, I was 202 lbs. Just now starting to slowly stop taking them by skipping days. I have had a total weight loss of 38 lbs in 3 months. The first month was the quickest results. I've eaten 1200 calories daily, drank water, and worked out extremely for 4-5 times a week. Experience headaches due to lack of water sometimes. I was dizzy when standing up too fast, had many sleepless nights from too much energy, even though my body was so tired. But I feel reborn. I feel so happy and confident. Of course, my body image isn't what I expected, but my journey has not ended yet. Adipex is a tool used to help change your lifestyle. I can't wait to say I changed my lifestyle and no longer need a pill, but I am thankful for it."

9 / 10
Was this helpful?YesNo
56 Report
  • Jen...
  • April 22, 2015

For Weight Loss (Obesity/Overweight) "I started Adipex 4/16 exactly 6 days ago. I started at 181 lbs, I am now down to 176.4 lbs. I have had occasional headaches and dry mouth, but as long as I keep losing this weight I need to lose, I can deal with it. My goal is to lose all my pregnancy weight I put on with my second baby. 28 more pounds to go!!"

9 / 10
Was this helpful?YesNo
56 Report
  • Bri...
  • Taken for less than 1 month
  • January 16, 2020

For Weight Loss (Obesity/Overweight) "I had this medication Adipex-P last year and had horrible side effects. It was like a sinus headache and muscle spasms. I lost 10 pounds and gained it all back when I got off. So last week, I decided to give it another go. I was doing good, no side effects. Lost 8 pounds, now the side effects are coming. This time it’s different. I had one muscle spasm and since then my legs have been very heavy and felt very weird and sore. I don’t know what to think about this pill. As far as weight loss, it’s great, but side effects, yeah, I’m not feeling good about them. Actually, kind of scared. But if you want to lose weight, go for it. My friend has been on it and has had a totally different experience from me. No side effects whatsoever."

6 / 10
Was this helpful?YesNo
38 Report
  • Anonymous
  • Taken for 1 to 6 months
  • October 26, 2012

For Weight Loss (Obesity/Overweight) "Adipex is fantastic. Although I haven't really felt 'energized', I'm totally eating a lot less. I don't have that hungry feeling, and it really helps me to make better choices, as I'm not always famished. In 6 weeks, I've lost over 20 lbs, which is something I never thought was possible. I'm really not even worried about coming off of it, as I think I've made a total lifestyle change. I'm never going back to being that fat person again! I've had virtually no side effects, except I do get headaches. Honestly, I don't think it's the pill though, but the fact that I'm not eating a whole lot and my blood sugar is probably lower than normal. I highly recommend this medicine."

9 / 10
Was this helpful?YesNo
67 Report
  • Mal...
  • Taken for 1 to 6 months
  • July 6, 2017

For Weight Loss (Obesity/Overweight) "I have taken Adipex for one month and 4 days, 22 pounds down. Starting weight 240, now at 218. I plan to stay on the pill until I reach 180 lbs. I am a very active person and eat great. First couple days I did have headaches, which only lasted 2-3 days, now I have had none. The boost of energy is nice. I do experience some dry mouth, thankfully, I LOVE water! I'll post in another month, hopefully, I will be under 200 pounds!"

10 / 10
Was this helpful?YesNo
46 Report
  • Red...
  • September 13, 2015

For Weight Loss (Obesity/Overweight) "At a starting weight with a new doctor, 440 lbs. I tried Adipex. I only took it a week before I stopped due to headaches, heart racing just getting up to go to the bathroom. But with sheer willpower alone, in one year I lost 120 lbs. After losing an average of 10 lbs a month, my weight leveled out and I couldn't get but 5 lbs a month. So we decided to try Adipex again. I started on Aug 15 at 316, now, Sept. 13 - 295 lbs. This time, no side effects, I'm exercising more and feeling great. Hoping for the best."

9 / 10
Was this helpful?YesNo
53 Report
  • woo...
  • August 2, 2009

For Weight Loss (Obesity/Overweight) "I started taking Adipex on June 2, 2009. I have lost 28 lbs since then and feel so much better. I still have a long way to go, but I feel motivated to do it. The only side effects I had were headaches and dry mouth. But I drink tons of water to help with the dry mouth, so that isn't such a bad thing. I would recommend this to anyone who needs to lose a significant amount of weight. You must do it right though and be sure to eat. Sometimes I have to force myself to eat."

10 / 10
Was this helpful?YesNo
71 Report
  • Zul...
  • Taken for less than 1 month
  • March 7, 2017

For Weight Loss (Obesity/Overweight) "I started Adipex last Tuesday, 2/28/17. My starting weight is 208, today, 3/6/17, my weight is 190.3. I'm amazed with this pill. The first day, I felt a very slight headache, I thought it was because I didn't have my regular cup of coffee, so I had one. I experienced slight nausea, but it didn't last long. It's amazing how my appetite has decreased, and I can't eat my meal completely. Until yesterday, I didn't even feel hungry. Today, I felt hungry around 10:30 am and ate just a 1/3 of a protein bar. At 12, I had half of the leftovers from yesterday's dinner because I had no desire to finish. I'm very happy so far. Also, I have no problems sleeping. I take my pill every morning at 7 and eat a protein bar for breakfast an hour later with 16 oz of water. Total: 10 daily."

9 / 10
Was this helpful?YesNo
41 Report
  • Ski...
  • November 15, 2016

For Weight Loss (Obesity/Overweight) "The first week, I had to force myself to eat. I didn't have a taste for anything, but once I took my first bite, I ate it all. Two meals a day: big breakfast before the pill. The second week, it was self-control, slight headaches from missing meals, so don't skip meals. I drank tea so I could use the bathroom. Ate high fiber foods and high protein foods. No sugar, no drugs, no alcohol, no caffeine, don't drink alcohol with this medicine. Alcohol is a depressant, and APEX gives you energy. You are going to feel so weird, plus, alcohol is sugar, it's empty calories. I lost a total of ten pounds in two weeks. I'm going on my third week. Stay at 2000-2500 calories per day. Drink water, no snacking, eat salad if you get the urge. I'm a medical student, hope this helps."

10 / 10
Was this helpful?YesNo
41 Report
  • Ash...
  • February 28, 2017

For Weight Loss (Obesity/Overweight) "I have been taking these pills on and off since last year. When I am strict with my diet, I see amazing results. My body has adapted to them, so that is my only downfall. They are not as effective as when I first started them. To anyone having side effects, I was having terrible headaches and dry mouth. My doctor offers name brand and generic pills. The generic pills give me massive side effects, I can only take name brand. If you are having side effects, take 1/2 pill in the AM and the other 1/2 pill late morning. That way, you can split the dose, it will stay in your system longer and may help with evening crashes."

9 / 10
Was this helpful?YesNo
33 Report
  • kcb...
  • Taken for 1 to 6 months
  • May 20, 2015

For Weight Loss (Obesity/Overweight) "Start of 2015, my weight was 262, and I am 5'5. I started going to the gym and eating right and lost only 4 pounds in 3 months. I went to the doc, and he put me on Adipex 37.5. First month, I lost 21 lbs. I am on week 2 into the 2nd month and down 5 lbs. Dry mouth and headache in the first month, but haven't had a problem in the 2nd month."

10 / 10
Was this helpful?YesNo
40 Report
  • Anonymous
  • Taken for 1 to 6 months
  • March 18, 2015

For Weight Loss (Obesity/Overweight) "I was personally not on this pill, but my mom was and currently still is. Though she has lost about 20 lbs in the last month or so, she has been experiencing side effects. First off, she's had severe headaches since starting the medicine. She's had extreme mood swings and is very nauseous and dizzy at times."

1 / 10
Was this helpful?YesNo
57 Report
  • Ali...
  • Taken for less than 1 month
  • June 14, 2013

For Weight Loss (Obesity/Overweight) "Week 1: Pros lost 10 pounds, eat less. Cons: had headache for 6 days, pills wear out by afternoon, 5-6 pm. Analysis: user must put effort into portion control or weight will come back after finishing with medication. Will follow up in another week. Meal plan: 1500 per day. Exercise 5 days a week cardio, and strength."

8 / 10
Was this helpful?YesNo
56 Report
  • mor...
  • August 29, 2010

For Weight Loss (Obesity/Overweight) "I started this medication August 27th, 2010... a few days ago. I normally wouldn't tell anyone what I weigh, but I'll tell you all, 263 pounds. I'm 21, I have high cholesterol. I just decided one day that I had enough. So, I made the appointment at my local bariatric clinic. She gave me a combination of Phentermine and Phendimet, as well as a thyroid pill. The first day taking the medication was weird. Cold sweats, nervous, but I did day two, and I felt just fine. A little headache, I'm not sure if it was the medication that did it or my lack of caffeine. I stopped drinking Dr. Pepper. I haven't taken it that long, only three days. But I feel good and I am already eating better. I know when I am full. I hope this was helpful to someone."

8 / 10
Was this helpful?YesNo
47 Report
  • Laz...
  • September 28, 2019

For Weight Loss (Obesity/Overweight) "I'm 21 years old, starting weight was 169 lbs, and I'm 5 ft 7 in. My doc gave me this to lose 40 lbs in 3-4 months to get down to 125-130 lbs. I had to research everything on my own. The first day I took 37.5 after dinner at 6. The next hour I was doing HIIT workouts from an energy burst. First week I had headaches, excessive sweating, dry mouth, and a bad taste in my mouth/lips no matter how often I brushed my teeth. Headaches probably from dehydration/not eating. I had NO appetite. I lost 8 lbs the first week. Second week, headaches calmed down, but I was getting used to the meds, so I split them. 1/2 around 8-9 a.m. and the next 1/2 around 3-5 p.m. It's my third week, and I've hit a stopping point with losing weight. I don't workout or meal prep, but I need to. Meds shrink your tummy, not your skin. DO NOT drink/smoke cigarettes. Mixing an upper/downer/nicotine causes bad side effects. Don't think of these as a 'Miracle Pill'. The long-term effects can be really harmful or addicting."

6 / 10
Was this helpful?YesNo
30 Report
  • Tha...
  • Taken for less than 1 month
  • August 27, 2018

For Weight Loss (Obesity/Overweight) "I am a 48-year-old female who has been battling weight issues for over 10 years. I stopped smoking cigarettes on 3/3/13, and my weight took a jump up for the worst. I lost my willpower after gaining so much weight. I began to stay in the house and withdraw from social events because of being ashamed. I began taking Adipex on 8/15/18, weighing 234 lbs. As of 8/22/18, I weigh 227 lbs. THAT'S 7 LBS IN 7 DAYS! Today, 8/26/18, I haven't weighed myself, but I'm sure I've lost more. I have no appetite or cravings. Now that I see results, there is no turning back. Just wait until I exercise, oh boy! Side effects are slight headaches, jitteriness, sweating, and loose stools. The jitteriness gives me energy, so I don't mind."

10 / 10
Was this helpful?YesNo
26 Report
  • Hop...
  • June 30, 2010

For Weight Loss (Obesity/Overweight) "Update from 06/24/10 post! I have been on Adipex 37.5 for 2 weeks and 3 days now. I have lost a total of 13 pounds in this amount of time. The only problem I have been having is headaches, so I am taking myself off this medicine for about 3 days. I'm still walking every day, doing light weights, Zumba once a week, and not taking the medicine on weekends. I do notice that I am a little hungrier when off the medicine, but I just find something to keep my mind off food. Like I'll get up and take a walk outside or go chat with a co-worker. I keep Graham crackers, fruits, and water for snacks when I get the hunger feelings. Starting weight was 251 lbs, current is 238 lbs. I will keep updating!"

9 / 10
Was this helpful?YesNo
46 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.