Mirtazapine for Depression User Reviews (Page 2)

• Flo...
• November 2, 2016

Mirtazapine "Feeling fantastic, like myself again. Wanted to say I have not gained weight, in fact, I have LOST WEIGHT with this drug. My appetite increased but I needed it. I liked to skip breakfast and lunch most days to 'lose weight'. I only kept the fat on. With this newfound energy I'm experiencing, I'm more active and burning more calories. My increased appetite has prompted me to eat regular healthy meals and my metabolism has skyrocketed! I'm burning fat and building muscle. Just wanted to put in my 2 cents. A lot of people gained weight, I have not. If you watch what you eat and your portion size, plus exercise regularly, you shouldn't see an unwanted weight gain with this drug."

• mar...
• April 4, 2015

Mirtazapine "I've been taking this medication for approximately 3 years now. For all who are upset with the weight gain and sleepiness, it doesn't last forever. I think I gained about 10-15 lbs in my first few months, but I've managed to lose it all. Now I am only sleepy right after I take it (at bedtime) and I wake up feeling rested without the hangover. It's definitely levelled off my depression, and I feel normal. If you can get past the first few weeks, this medication is a life saver. I truly forgot that this medication even has side effects, since I've been on it so long. Also, I tried the SSRI/SNRI route first. On Zoloft, I would've made a great cast member for the Walking Dead. I've never felt more like a zombie. Remeron is the best!"

• Nev...
• May 14, 2020

Mirtazapine "I literally split a 15mg down to into 8ths because my body is so sensitive. Wow... I have been out of it for DAYS. I cannot stop sleeping. Put me in a horrible weird state like I don't know what's going on or like I'm truly awake. Just feel 'out of it'... Off of a sliver! I have read contradictory things about dosing. I would indeed say and agree with that the lower doses are VERY sedating. Very weirdly vivid (not nightmarish) dreams... I had a gene test done and this medication was on my 'lower doses maybe be required'. I can't even imagine what a high dose would do! This is completely staying on my 'NO!' list! Be careful of this medication because it is POWERFUL. I feel like I've just been high for days. Like I've just been smoking the most dank weed and I've just been stuck in this high. When I wake up, I feel like I'm manic, like I just have a huge rush of anxiety. I wanted to try this because I am experiencing 'heartburn' like chest pain that isn't acid-related at all."

• Aus...
• Taken for less than 1 month
• December 6, 2024

"I've been taking it for a week. I was taking sertraline before for PTSD, which led to depression and anxiety. I take it at night, 30 milligrams. It's such a relief to be able to sleep, and I can feel that my mood has improved. I feel more like myself, less cranky, which is very fun. Just little changes, but it's only been a week. I'll write back in six weeks."

• Anonymous
• Taken for 2 to 5 years
• June 1, 2019

Mirtazapine "I've been on Remeron for several years now. Primarily for insomnia but also for anxiety and depression. This medication helps me tremendously like no others I've tried. No side effects besides hunger and weight gain. Highly recommend"

• Ano...
• Taken for 1 to 6 months
• August 12, 2019

Mirtazapine "I was started on 7.5 mg of Remeron when I was having anxiety and panic attacks. Within a few days, I started feeling significantly better. A few months later, and I have had only a few minor episodes of panic. It has greatly improved my life with no major side effects."

• Anonymous
• February 21, 2012

Mirtazapine "I have been on Remeron for a little over 3 months for depression and anxiety. It has changed my life after years of insomnia and depression. I think I finally found what works for me. The first couple of weeks are rough though, I felt tired all the time, especially the first day, I slept 21 hours! It gets better after about 3 weeks. I am depression-free, and I sleep a whole lot better than I used to. If you are afraid of the side effects, don't worry, they will diminish after about a couple of weeks... just stick it out, it's well worth it. I have taken almost every antidepressant in the books, and Remeron is the only one that has worked for me. I think you should give it a try, it works for a lot of people!"

• lae...
• Taken for 1 to 6 months
• June 19, 2023

"Mirtazapine almost killed me. I was severely depressed and put on a low dose to help me sleep. It did not sedate me at all but made me dangerously suicidal. I tried to take my life repeatedly. The doctor said the low dose was the issue, so he upped it, which did not make a difference, except that I put on 2 stone in weight. I was on it for 3 months and then refused to take it anymore. I came off it 3 weeks ago. Suicidal thoughts have gone, I have lost half a stone in weight, and feel so much better. Nobody warned me that I could become dangerously suicidal, and my life was put at risk. I will never take antidepressants again. Be very careful when taking this stuff, make sure you know all of the risks!"

• Anonymous
• October 19, 2012

Mirtazapine "I have been on Remeron for 3 years now and it's the best antidepressant I've ever been on. I have tried Prozac, Celexa, Wellbutrin, and Effexor. Remeron is the only one that made me happy to be alive. I did gain about 3 pounds but then was feeling so good I decided to become a vegan and improve my physical health, which before I could have cared less about. So now I've lost the pounds. Plus, a few pounds is definitely worth the improvement in mood and sleep. I have found it's really important how much I take and at what time. I did get restless leg syndrome which made it hard to sleep so I tried breaking up my 30 mg pill and taking 1/2 at 7:30 and 1/2 at 9:00 pm. That wasn't helping my mood. For best results, I take 30 mg at 6:00 pm and go to bed at 9:00."

• K_T...
• September 12, 2009

Mirtazapine "This antidepressant has been a blessing in my life. I was 25 lbs underweight due to depression, and also had sporadic sleeping. The side effects are a benefit for me. It makes you hungry, especially after you take it at night. I crave lots of carbs, and have been eating like I have never before. I have gained 11 lbs in just 1 month on Remeron. It also has a nice sedation effect to help with sleep. When I take my 30mg dose at night, I have everything ready because after 45 minutes I can barely keep my eyes open, and then get a great night's sleep. Side effects are worse during the first week, and then everything balances out! If you suffer from sleep and/or eating, then Remeron could be the biggest blessing in your life also. It gave me hope."

• 172...
• May 8, 2023

Mirtazapine "I was on Remeron for 2 years, but over that time, I just got worse. I tried coming off three times, but the withdrawal was hell on earth! Luckily, but not lucky, I had a near-fatal car crash. I was in a coma in ICU for a month, then in the trauma ward for another at Southmead, Bristol. For some reason, they took me off Remeron when I first went in. Eventually, when I came around six weeks later, after the delirium had gone, I felt better than I had for the last two years while being on Remeron. Even with a broken tibia, broken hip, broken jaw, damaged vertebrae, blood clots, and 2 cardiac arrests, it was worth it just to get off that poison!"

• Neo...
• July 23, 2019

"I suffer from severe depression and anxiety. I would cry randomly at home, work, in public. I couldn't be around large crowds, I would have panic attacks. Self-isolated and constantly had suicidal thoughts. My MD started me on Wellbutrin and I reached the max dose of 450 mg. It didn't help. After my second attempted suicide, my doctor prescribed me Mirtazapine 15 mg. It started working immediately. I take the pill every night. After my first dose, I woke up the next day super tired and lethargic. The second day, the lethargy was gone. By day 4, I felt like a new person. I started thinking more clearly and was able to manage my anxiety and depression. I still feel anxious and still have sad thoughts, but not to the point of feeling suicidal. I do have to work harder to keep my diabetes under control because of the increased appetite, but the benefits of the medication far outweigh the side effects. I know this medication affects everyone differently, but this drug literally saved my life."

• Ric...
• Taken for 10 years or more
• July 11, 2025

"Wonderful for depression. 45 mg gives me energy, therefore, I have to take it in the morning. If I take it before bed, I will be awake the entire night. I don't use it for sleep. It, along with Lexapro, are my antidepressants. It increases dopamine, norepinephrine, and serotonin by blocking A2 presynaptic auto and hetero receptors. So it is not an SSRI or SNRI. But it makes more monoamines in other parts of the brain. Goes great with Lexapro 20 mg."

• lob...
• Taken for 1 to 6 months
• October 15, 2023

Mirtazapine "I had tried Lexipro (sexual side effects) and Trintellex (worked a little for a while but eventually had no benefits). I also tried Trazodone which addressed the sleep a small amount but not enough to improve my overall mental health. A psychiatrist told me Remeron is known to address depression, sleep, and appetite. He was right. It improved all three. The only side effects were weight gain (which I actually wanted) and crazy dreams. I thought the dreams would subside after taking it for a while but they never really did. They aren’t nightmares, just very odd dreams. I was started on 7.5 mg. After about five months, I’m still on 7.5 mg. I definitely recommend it for sleep, depression, and lack of appetite."

• Ali...
• Taken for 1 to 6 months
• July 4, 2025

"I started taking mirtazapine 15 mg for the negative symptoms of schizophrenia and depression. At first, it worked like a miracle for sleep — I felt great for the first two days. But then, my depression actually got worse. Still, I didn’t give up. I continued taking it for 3 months, and slowly, things began to change. After three months, I finally noticed real improvement — better mood, better sleep, and even an increase in libido. I had tried many other medications before on my own (like fluoxetine, sertraline, Seroquel, olanzapine, Xanax, and lamotrigine), but none of them worked for me. Mirtazapine at 15 mg turned out to be the right dose for me. Thanks to this medicine, I feel alive again. Before, I was suicidal, and now I have hope. My advice to others: give the medicine time to work. It may take weeks or even months, but it can truly make a difference like it did for me."

• Kes...
• June 2, 2020

"Took for about a month, starting on 15 mg a day. Never been so tired in my life. Went up to 30 mg because the tiredness is supposed to ease then. It did slightly but after a few days my skin was like sandpaper and eyes constantly watering, and both very sore. Didn't really feel better at all mentally, actually worse because I felt I had dropped about 50 IQ points and not able to think clearly to find solutions to problems. Felt despairing, too despairing to demonstrably show anger but there all the time in my mind, along with the worst depression ever. I needed to find something that I know I have to live with for the rest of my life. Took hours to wake up, a few hours where I would be sort of functioning, then go to bed very early, not just because of exhaustion but also because I couldn't do anything anyway because of constantly wiping my eyes."

• Tie...
• Taken for 1 to 6 months
• April 30, 2019

Mirtazapine "Started taking Remeron 3 months ago. I have severe anxiety and insomnia which in turn caused depression. I became dependent on Ativan after being hospitalized. I took the Remeron while weaning off the Ativan. I never thought my body would recover. I suffered through the withdrawals and while waiting for the Remeron to kick in. It helped me sleep starting the first night. Ever since I’ve been sleeping an average of 9 hours a night, which I desperately needed. For my anxiety and depression, it was a gradual effect and took almost two months to work. I’m glad I stuck with it. Don’t get discouraged when starting this med. It takes time to work. I’m happy to say I’m no longer dependent on Ativan. I only take it as needed, which is rare. Remeron has helped me wean off the Ativan as well as being able to function daily without constantly being on the edge."

• Anonymous
• February 17, 2011

Mirtazapine "Remeron is a unique medicine, since its side effects are sometimes as useful as its antidepressant effects. This medicine literally saved my life. For many years, I was around 90 pounds, and never slept. Now, I'm a healthy 120 and I sleep about 8 or 9 hours per night. It did take a long time to get to this point. When I first started taking it, I was tired all the time and very worried about the ravenous hunger! But now that I've been on it 2 years, I no longer gain weight, I'm no longer tearful and miserable, and I've honestly never been happier. God bless the people who made this drug. It literally saved my life."

• Sup...
• Taken for 1 to 6 months
• October 21, 2019

"I really don't know if this is working for me. I fall asleep easily but just feel lost in life. I feel like the world is against me, and I only want to wake up and be my old self. I used to be really funny and light up the room. Now I feel like I just don't fit in and awkward."

• Smo...
• January 5, 2015

Mirtazapine "I didn't experience a crazy increase in appetite, however, I did gain motivation that I previously didn't have to go to the gym and lift weights, which helped me put my weight back on. Side effects for me included slight numbness of the tongue, and I feel like I mumble a lot because of that. Side effects do not bother me due to the fact that I feel so much better because of the medicine."

• amo...
• April 10, 2015

Mirtazapine "Doctor prescribed me Remeron. I've been taking 15mg for about a month now. I've noticed an increase in hunger and I get great sleep with this medication. However, it hasn't helped with my anxiety attacks or depression. I also noticed that I'm becoming more and more forgetful, often find myself staring at nothing in a daze, and it's hard to articulate what I'm thinking or feeling."

• Ash...
• Taken for 1 to 2 years
• July 11, 2019

Mirtazapine "Terrible! Never again. I gained 13 pounds, and I'm normally a small person. You gain every few months. I felt like I was in a fog the whole time with no personality, and I didn't realize it until I got off. I refused to gain more weight and told them I'm getting off it. They told me to just stop taking it. DON'T! I did since they said to, and my anxiety spiked to a 10, and after a few weeks, I had a nervous breakdown. I also had insomnia for months and slept maybe 2-3 hours a night for the first two weeks until I said put me back on so I can wean myself off safely - the right way. It's been about 5 months off, and I still have insomnia, which could be lifelong. No one told me I would be addicted to this med."

• Way...
• Taken for 1 to 6 months
• September 25, 2018

"I was put on mirtazapine 15 mg after trying citalopram and also sertraline for depression. Mirtazapine has saved me from committing suicide. The first couple of days were rough where I felt awful and sluggish, but then those side effects just disappeared, and now I feel great in the day and have enough energy for anything I want to do. It's been a godsend for me, and I hope somebody out there will read this and ask their doctor for it because honestly I just wanted to die, and now I'm getting back to being my old self."

• hal...
• April 18, 2012

Mirtazapine "I have it all...anxiety, depression, and insomnia. Sometimes I can be anxious in the morning, depressed in the afternoon. I have tried Wellbutrin/Cymbalta combination, Pristiq, Viibryd, Effexor, and every SSRI. I definitely felt an improvement with Cymbalta/Wellbutin and Pristiq, but not 100% myself. Remeron has been a godsend to me. It works fast; dare I say I am in a good mood again after only three days. I was a bit tired in the morning, but I will gladly take some fatigue to get rid of the anxiety and depression, and I hear this goes away in time. As far as the weight gain, I have always been a good eater and go to the gym, so if my appetite increases (it hasn't as of yet), I will just have to monitor it. So far, it's been great."

• -D-...
• May 25, 2016

Mirtazapine "I have taken 15 mg Remeron for about 5 days so far and it already is a miracle pill for me. I am slightly underweight and had constant anxiety, but so far this medication has vastly improved my appetite and I just feel relaxed, but not in a drugged feeling way. I actually enjoy food and am no longer as picky of an eater as I was before, which is awesome. It also helps with sleep, as it certainly has a sedative effect after you take it. I was really groggy and tired the first day after I took it, but have been fine and energized every day since. I know every medication affects people differently, but if you are depressed and not worried about weight gain, give this a shot."