Keppra and Irritability: What Users Say (Page 2)

• Lyn...
• Taken for 1 to 2 years
• January 10, 2022

For Epilepsy "I took this medication during my pregnancy with my youngest son. I had almost 160 seizures during the pregnancy, plus I was a horrible person to be around due to the constant irritability. It was horrible. My son was delivered early to try to get me on a better medicine. My doctor suggested we try it again after the pregnancy, and it still didn't work. Horrible medicine!"

• Kri...
• Taken for 1 to 6 months
• May 12, 2025

"With each Keppra increase, I feel short-tempered, grumpy, tired, depressed, and definitely mad at the world, and an anger for myself as well for not being a better version of who I am. I think symptoms last like two or three weeks? My husband might beg to differ. I do need to try that vitamin B6."

• JRC...
• Taken for 1 to 2 years
• March 22, 2022

For Seizures "I started having seizures when I was 35. I’m now 72. I took Depakote for 35 years and was mostly successful in avoiding seizures, although I did have periodic breakthrough events without warning. About two years ago, I noticed I was getting frequent mouth infections. At this point, the neurologist weaned me off of Depakote over a six-week period and at the same time gradually increased the Keppra to 1500 mg per day. For the first three weeks on Keppra, I was tired and irritable, but that soon subsided. I took a precautionary EEG as well. So far, no seizures and no mouth infections."

• Emo...
• Taken for 1 to 6 months
• July 27, 2021

For Seizures "I was put on this medication after one seizure with no history of seizures of any kind. This medication is horrible!!! I plead with anyone who is taking this to ask for help, and if you have a loved one on it, know that they need your help. It causes severe confusion, nosebleeds, aggression, bad dreams, and irritability to name a few. My doctor was adamant that I needed it, but when I finally forgot to take it one day, I had a moment of clarity and looked up its side effects. I was floored that I was ever put on it. It was by far the worst experience I have ever had with a medication, especially one I didn’t need! I weaned myself off of it and worry about long-term effects from taking it for so long. I implore everyone to find something else if you suffer from seizures and ask a loved one to help you if you are having any of these horrific side effects. God bless you and good luck to you all! I give it a scale of 10 on effects for very negative side effects."

• pat...
• December 27, 2007

For Seizures "Keppra has been a difficult drug for me. I have had mood swings, mouth sores, no sleep, anger, and agitation."

• Win...
• Taken for 5 to 10 years
• January 16, 2016

For Seizures "Falling asleep most of the day and feeling zonked out. They do help, but there must be a kinder drug they could use on us. Also, I am grumpy, but then that could be me."

• Con...
• August 14, 2016

For Epilepsy "Anger, moodiness, hopelessness, irritability, trouble making cohesive thoughts, very serious suicidal urge. Same day after the first pill of 500 mg."