Leuprolide and Mood Swings: What Users Say (Page 3)

• Mar...
• Taken for 1 to 6 months
• September 28, 2024

Leuprolide for Uterine Fibroids "I have been on Lupron for 4 months, about to have my fifth shot. I have a 10 cm submucosal fibroid which was causing pain, severe bleeding, and anemia. Since starting the Lupron, my migraines increased by double (I had to switch meds so I could go to work). I’ve gained 10 pounds, I have night sweats, hot flashes during the day, my mood gets angry and sad the week after the shot, and now my hair is thinning. I also am still bleeding daily (spotting). I was put on progesterone to offset some of the side effects. I have two more shots until my second surgery, and I can’t wait to be off this medication."

• Sco...
• Taken for 6 months to 1 year
• May 17, 2023

Leuprolide for Prostate Cancer "Diagnosed with prostate cancer with a Gleason 7, PSA 8.2. Received a 6-month Lupron shot on Nov 15, 2022, and 20 sessions of radiation starting Jan. 18, 2023. I have suffered hot flashes several times a day and night, and they have become more intense in the last 6 weeks, by that, I mean I get completely soaked several times a day and night. I have gained around 20 pounds, have a loss of muscle strength, neuropathy in my hands, bone pains in my feet, back pain, mood swings, and lack of motivation to get moving. I do ride my bicycle several times a week, about 100-plus miles, and this is how I keep my sanity. Last appointment with the doctor was on May 15."

• Nat...
• Taken for 1 to 6 months
• July 7, 2022

Leuprolide for Uterine Fibroids "I have had many years of heavy, painful periods. Diagnosed with a bulky uterus (size 16 weeks) with endometriosis and fibroids. My gynecologist recommended Lupron Depot to shrink my uterus before going for laparoscopic hysterectomy. I'm 53 years old. I have had 2 shots now and am going for my 3rd next week. I have had a lot of side effects from this medication: night sweats (not every night, mild), insomnia, no energy, restless legs/muscle spasms, depression (cry every day at least once), and mood swings (my poor family). So next week when I get shot #3, I am hoping that he will have my surgical date booked as I cannot live with the pain and constant bleeding. The shot plus add-back therapy has only given me hope that I will eventually get back to normal and a better quality of life."

• Che...
• June 27, 2018

For Uterine Fibroids "I have been taking the Lupron shot for fibroids. I was bleeding so heavily I was wearing diapers, I could not wear pads anymore. When I suffered my sixth stroke, I told my doc, "Look, you are not putting me on any blood thinner until you fix the problem down there." The first shot, I bled afterward for like three days, but not as heavily as I normally would. My next shot is in July 2018. The first time I took the shot, I had mood swings, hot flashes at night, headaches, and sleeplessness. It takes you on a journey, but my fibroids are shrinking tremendously. The newest side effect I discovered is swollen gums. No fun. Do what you can to preserve your smile while taking this drug, or you can lose your teeth. I used to have a beautiful smile, now that is gone. The only drawback I have."

• enq...
• February 9, 2016

Leuprolide for Endometriosis "So my gyn started me on the Lupron a little over a week ago. I have had some horrible mood swings, severe pain worse than when I began, swelling in my hands and feet, and I started to bleed very heavily late last night. Has anyone else had these experiences? Did they get better over time? My biggest worry is I suffer from anxiety and depression prior to the injections. Things have been getting worse, is this normal, or should I be worried?"

• Ric...
• October 27, 2020

For Prostate Cancer "I was diagnosed with advanced prostate cancer-non-metastatic-in July 2019, with a Gleason score of 9, 8, and 7. Began Elegard/Lupron in August 2019, 2 months prior to 45 days of radiation, and have continued on a 4-month regimen of Lupron injections. During the first year on this drug, I had the basic side effects of hot flashes, chills, mood swings, and some aches. Now going into the second year on Lupron, I have severe side effects with a lump on my left knee with severe swelling with overuse; pain in my hips and shoulders that come and go; tingling and numbness in my hands that wake me up at night; ringing in my ears; fatigue; and I have lost the ability to use my right thumb that comes and goes like severe arthritis. I was previously a very calm and caring person, but now I become angry and have high-risk behaviors, not caring if I get into an argument with someone, which I try to control. I used to be an avid runner but cannot do this anymore due to severe pain and swelling in my left leg."