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User Reviews for Fluorouracil topical

Also known as: Efudex, Tolak, Carac, Efudex Occlusion Pack, Fluoroplex

Fluorouracil topical has an average rating of 7.5 out of 10 from a total of 260 ratings on Drugs.com. 67% of reviewers reported a positive experience, while 16% reported a negative experience.

Condition Avg. Rating Reviews Compare
Actinic Keratosis  
7.3
106 reviews 9 medications
Keratosis  
7.9
72 reviews 17 medications
Basal Cell Carcinoma  
7.5
42 reviews 7 medications
Skin Cancer  
7.7
38 reviews 2 medications
Warts  Off-label
3.0
2 reviews 30 medications
Summary of Fluorouracil topical reviews 7.5 260 reviews

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Fluorouracil topical

BQ · Taken for less than 1 month · April 25, 2020

Efudex (fluorouracil) for Keratosis: “I'm a 68 year old male. This is the second time I have used this fabulous cream. Enjoy the results, YES! Enjoy the experience, NO! I applied the cream twice a day to my entire face for two weeks. After two further weeks, all of the scabbing has gone and my face has peeled. Still a few weeks to go before the worst of the redness goes. I must be honest - the pain was bad: Burning sensation, needle pricks, scabbing and blood spots on my pillow. Sometimes it was so bad, I had to ease the pain with ice. But all of the pain described above was worth it. The cream detects the worst affected areas - some I had no idea were damaged. It leaves the undamaged skin alone. This cream has reduced my number of visits to the seriously expensive dermatologist to almost zero. My skin feels and looks twenty years younger. I cannot recommend this cream enough, You should be thrilled with the results. But, as with most rewards in life, there is some serious pain involved.”

10 / 10
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Anna · Taken for less than 1 month · October 13, 2020

Efudex (fluorouracil) for Keratosis: “I’m 52 yo sun loving female and started treatment of Efudex. I’m 3 weeks in and last dose on day 20. I didn’t react too badly to start at all. 3rd week in saw big changes as skin became more inflamed but very manageable. I was anxious with all the reviews I read but think it’s important to remind ones that everyone is different. The last day and night after finishing has been the most painful. I’m Putting 1% hydrocortisone on in ointment form. Keeps area oily Some benefits of COVID are mask wearing. With hat sunnies and mask I can go out and people don’t notice how hideous I look. Taking pain relievers to sleep. Itching, burning at night is worst. I’m a runner and I’ve continued all the way thru but will see what the next few days brings.”

9 / 10
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JG · Taken for less than 1 month · May 2, 2020

Efudex (fluorouracil) for Keratosis: “This is my second time around for using efudex. The first time was 6 years ago. I've grown up on the West coast and spent my summers in the deserts or at the beach. I am of Irish descent, brown hair, blue eyes. By the time I was 60, my face looked terrible. High danger for skin cancer, many trips to dermatologist. Began to hurt significantly on day 14. Everything I read and saw on the web said "stick it out". I made it to day 25, Couldn't do another minute. Dragged myself into the doc's office on a Friday afternoon. I looked like Frankenstein. Appt's clerk gasped. Doc said "Great job. Looks like it was very effective." That night I washed everything off, and applied Aquaphor. Next two days were most painful. After that, it got better every day, and within two months, there was no trace of the 40 years of sun damage on my face. So...I would give this a 10. I'm a teacher, and did the treatment over the winter holidays. It was all done by January 7”

10 / 10
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j mack · Taken for less than 1 month · September 27, 2015

Efudex (fluorouracil) for Keratosis: “This is the best!! I've been using it for 4 years and it is absolutely the best solution for AK's. I am 60 years old, fair skin, been outside for years and developed way too many AK's, not to mention basal and squamous problems too. For years, the dermatologist only used spot nitrogen and prescribed caramac. I can only assume she didn't prescribe efudex because she needed the steady income stream from me and my insurance. By chance I was having a physical from my family doctor. He asked me when I was going to address my AK;s on forehead. I told him I did, and he told me he could write me a prescription for medicine that solves it, efudex. He did and I amazed at the ending results. Yes, the efudex was painful, looked bad when it was working but results speak for them self”

10 / 10
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Neen · Taken for less than 1 month · August 27, 2020

Efudex (fluorouracil) for Skin Cancer: “I have been using the Efudex cream for 10 days now. I have come out in red spots on my face but I am in no pain, as yet. I am wondering if I am using it correctly. The blotchy spots are crimson but not sore. Will it get worse because I was scared to use it but so far so good as far as pain is concerned. I do look weird though with these red spots everywhere.”

6 / 10
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Rankin · Taken for less than 1 month · October 29, 2019

Efudex (fluorouracil) for Keratosis: “Put it on the obvious parts of my face that I thought needed to be treated, found that the Efudix somehow seeped to cover much more of my face, had lots of redness followed by crusty scabbing, had to stop treatment after just short of 3 weeks as my eye were in agony with stinging gritty feeling, even though I didn't put any anywhere near my eyes - wonder if gets into sinus system and makes its way there.”

9 / 10
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Cedric · Taken for less than 1 month · November 9, 2020

Efudex (fluorouracil) for Actinic Keratosis: “57 year old male, brought up in South Africa, lived in Australia and 30+ years in the military with sunny deployments. Prev suffered two SCC's and Bowen's disease. I'm in day 25 of Efudex treatment, stopped applying the cream after 21 days. My face is very red and itchy, it's amazing how the cream identifies areas of damage. It's been tough at times, sleepless nights with burning/itching. Strangely when I stopped applying the cream I suffered stomach acid, unsure if its relayed. The biggest challenge is to persevere to the end. I use Aquaphore from Amazon to soothe the itching. Good luck to everyone!”

10 / 10
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ford6970 · May 14, 2015

Efudex (fluorouracil) for Keratosis: “I am now into my 15 day of using the efudix cream and I look scary I was told by my skin specialist to do my whole face and as directed have done so .I am a 51 year old woman that grew up on the coast and never thought any thing of it. After having a melanoma removed last year the ugliness ,pain and itchiness of this treatment is far better than a alternative outcome .Like others googled pictures and was horrified but remember the out come will be beautiful I would do it again in a heart beat.”

9 / 10
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outdooraussie · Taken for less than 1 month · May 4, 2013

Efudex (fluorouracil) for Skin Cancer: “Age 66 - spent many years at sea and as you can imagine my facial skin was a mess. Doctor put me on Ufedix (how it is called here) two weeks ago and the results are amazing. Of course it is not a pretty sight and sleeping is a bit difficult, the reaction was clearly pictured in the brochure that I was given at the clinic - but it does not truly describe the actual sensations associated with the inflamation. A little concerned I browsed for reviews and found this sight - after reading the experiences of other users I feel much releaved - thanks to all for sharing their experiences, now I am looking forward to seeing the end result. Stay safe and keep well. Thank you.”

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Jojo · October 19, 2019

Efudex (fluorouracil) for Actinic Keratosis: “I am a 60 year old with very fair skin and blue eyes who grew up at the beach. I was regularly burned to a blister stage every year. I had many keratosis burned off from age 30 to 50. Finally advised to use Efudex. I have completed treatments on my face 5 times now over the course of these 10 years. I have an unusually mild reaction each time. In fact, I have to use it for 40 days to get the full benefit. So, you never know how your own skin will react. The dermatologists have been amazed at the length of time it takes me to get a reaction. But for the chest area, the reaction is incredibly painful, red, and fast. Maybe the constant freezing of those places on my face helped more than I know? In any case, Maybe it could be recommended to try a small area before using on the entire face. The end results are very good and I would not let fear keep you from trying this.”

10 / 10
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Anonymous · Taken for less than 1 month · July 29, 2020

Efudex (fluorouracil) for Actinic Keratosis: “I so appreciate all your comments. I am day 21 of Efudex and my GP wants me to keep going another week. I am applying to my nose, hands and forearms. My nose is a beacon as is the area around it. Thank goodness for COVID isolation as it couldn’t be happening at a better time. I was going to stop today but after reading everyone’s experience I will keep going for another week. Thank you”

9 / 10
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Richard - NC · November 14, 2010

Efudex (fluorouracil) for Keratosis: “I'm an engineer, now in my 60s, and I have worked outside all my life. I have red hair and fair complexion you can imagine the skin damage I have accumulated in my lifetime. I had used the Efudex 5% cream years ago and had good results. Three months ago I began seeing a dermatologist that recommended the "new" technology "BLUE LIGHT TREATMENTS". This did NOT work for me gave me a very mild "sunburn" with no apparent effect on the former skin damage and it was very expensive even after insurance coverage! I requested my treatment be changed to the proven Efudex my doctor insisted I stay with the "blue light", that my skin was "in very good condition" and that I only needed "maintenance". As you may guess I have changed physicians and now I am being treated with Efudex again. My skin is now in full reaction after only two weeks treatment with Efudex. Yes with Efudex your skin is unsightly and uncomfortable from week 2 through to week 4; but, this is a small price to be cancer free. Efudex works! ”

9 / 10
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Wayne from NS Canada · Taken for 10 years or more · August 30, 2016

Efudex (fluorouracil) for Keratosis: “Have used it for pre-cancer on my face probably 6 times since 1996. Using it now on a couple of spots on the back of my hand. Have always found it perfectly effective. Yes, after a couple weeks it begins to look raw and ugly, but that quickly clears up after treatment stops. In every case the spots were cured. Luckily I have never experienced any of the pain or itchiness that others have reported. Perhaps mostly the ones who had problems bothered to report? And I still have the original tube of the produce I got back in 1996, and yes, it still works. There was enough in it to keep me going when needed it and obviously it didn't go bad. The fact it's in a metal tube may have enabled it's long life vs a plastic tube.”

10 / 10
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Tiny704 · Taken for 2 to 5 years · October 12, 2015

Efudex (fluorouracil) for Actinic Keratosis: “I am a 70 year old male who suffers from Actinick Keratosis from exposure to the harsh rays of the sun. Efudex is a fantastic product. Does exactly what is claimed. Make sure that you wash your hands completely after each application. Do not get it on your lips or you will experience great discomfort, (cracked and bleeding lips). Once you have completed the process (twice a day for 21 days), use Hydroval Cream 0.2% to assist in the healing process (works great).”

10 / 10
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FanchonLinda · June 2, 2015

Efudex (fluorouracil) for Keratosis: “I have done this Efudex treatment three times over a 20 year time span. It is a hideous process but it beats the alternatives! KNIVES cutting you up in particular. I use and recommend AQUAPHOR instead of the expensive prescribed cortisone cream for a quicker more effective healing process. I think EFUDEX is Great!”

10 / 10
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Dans62 · Taken for 1 to 6 months · August 10, 2019

Efudex (fluorouracil) for Basal Cell Carcinoma: “I've had surgery for basal cell over the years and had an area near my nose. I used efudex as directed. Sure, it looked horrible after treatment it was a bit lumpy like it was scarred. I thought it didn't work. The area, came back totally cancer free and the lumpy look went away. You would never know it was treated. Well worth it. I'm currently using it on my cheek and hoping for the same result. ”

10 / 10
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Snozz · January 31, 2020

Efudex (fluorouracil) for Basal Cell Carcinoma: “Face was covered in about 7 areas after years of sun damage from working in the sun, used Efudex for 15 days applied 2 times a day till the 40mgs tube ran out , week 2 the pain was not nice but honestly go thought it it is worth it , Like having a face lift looking 10 years younger !!! Believe me it is truth . Using it on my arms now just started For any one going though a course, it really is impressive cream”

10 / 10
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Largo7 · March 5, 2013

Efudex (fluorouracil) for Keratosis: “Used the product on my face for 6 weeks twice a day for two days every week. Depending on the extent of sun damage, the effects are dramatic and nasty looking. After the 2nd week the treated area looks like a bad sun burn, it itches, peels, weeps, bleeds and burns. But the results after stopping for 3-4 weeks are very good.”

8 / 10
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Gdsangl5 · Taken for less than 1 month · September 13, 2019

Efudex (fluorouracil) for Actinic Keratosis: “Growing up at the Jersey Shore and summers spent at Fl Beaches, I fell in love with the warmth of the sun, and a healthy tan. At 55, the sun made my chest bubble up, and my legs reverse tan. It is no surprise that I had actinic keratosis multiplying fast. I was prescribed Efudex 5% for my chest, neck and face. I had no idea it was topical Chemo. What? I googled everything Efudux, bought Aveeno, vanicreme, Aquaphor, asked for anxiety med for my mounting fears and took a personal leave from work. Its Day 13, saw Dr., I'm done. I did look beat up. In the afternoon insane itching.. tap tap. Many more dead lesions, surface and crust up. I'm using cortizone, and aquaphor on the corners and for lesions around my lips. I will be doing this for years to come peeling back the many layers of damage. It has not been as bad as it was for others. It's uncomfortable yet tolerable, and much better than the alternative. The knife or Cancer. Oddly, I feel healthier and fortunate to be given this chance.”

8 / 10
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pdxbuc · August 9, 2010

Carac (fluorouracil) for Keratosis: “Just finished my 4 week course of Carac cream. Here is my advice. MOISTURIZE, MOISTURIZE, MOISTURIZE! I went to Rite-Aide and purchased a large bottle of Vitamin E and ALOE gel moisturizer (nothing with alcohol, which will burn or oil, which is difficult to remove) as well as a bottle of Baby Wash (you know, "no more tears"). Only wash your affected area (mine was face and scalp) with the baby wash (doesn't dry out skin) and once the Carac has been applied, wait about 1/2 hour and begin applying the moisturizer. I used the moisturizer heavily 5 or 6 times per day. It soaked right up and worked great. Felt like a light sun-burn with moderate peeling and when I was done and I healed up in a snap.”

10 / 10
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Boatman · Taken for less than 1 month · August 8, 2020

Efudex (fluorouracil) for Basal Cell Carcinoma: “Ten years ago I used Aldara over my whole face. 20 minutes of pain after each application and a violent reaction after 9 days. Face looked as though I had been in a bad fire and scared the kids at school. It did heal and I looked 10 years younger. I have just finished 3 weeks on Efudex and 3 weeks healing. Skin looks like the proverbial babies bottom and very happy with the results. This time I treated whole face, ears and parts of neck. Applying the Efudex was less painful than the Aldara, even a little bit soothing. Hard to sleep with sore ears. Tried all kinds of moisturisers and they caused stinging for 5-10 minutes. Used vaseline 2-3 times daily and it was by far the most satisfactory. Very pleased with the results. Also treated both arms at the same time. Used 3 tubes of Efudex on this session. Always worked outside and lots of boating. 76 years young now after this treatment.”

10 / 10
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LTOV · January 3, 2015

Efudex (fluorouracil) for Basal Cell Carcinoma: “This is my second time around. I am on Day 10 of a 14-day regime; then steroid cream for another 14 days. I am in excuciating pain and I look horrific. I know it's a good thing but it is so painful. I wanted to write here to help encourage others; I found this site because I needed encouragement. I use a dish towel with fringe to flap against my face and that's the only relief I get. I forget how awful I look until I catch myself in a mirror.”

10 / 10
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nwfmike · January 18, 2019

Efudex (fluorouracil) for Actinic Keratosis: “After years of sun damage, my whole face lit up like a Christmas tree full of red lights within 1 week of twice daily application. Shaving: No problem. Use a sharp razor and light pressure with a mild gel cream Washing: Try Simple Water Boost Micellar facial gel wash. Great stuff. cleans your face and does not leave it dry OR oily. Does not irritate the burning skin. Still use it every day to clean my face. Lubrication: Try Neutrogena Hydro Boost water gel. Not cheap, but you don't need much. Worked great, no greasy feeling. Used a chilled aloe mask at night during last week. Timeline: Should be able to finish in 3 weeks of twice daily. Still pretty bad for a week after treatment with first 2 layers of skin dried up and peeled away. Had another 2 weeks of peelings. After that, skin was super smooth but still red in some areas. Took another month for most of that to fade away. Definitely recommend using Efudex. It's obviously not fun, but produces great results.”

10 / 10
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Lee · Taken for less than 1 month · May 15, 2020

Efudex (fluorouracil) for Actinic Keratosis: “I am on day 15 of the Efudex cream. I was terrified to start. I was actually prescribed the cream two other times and chickened out due to the photos that I had seen on YouTube. I am doing very well so far. It is super tight and red around my mouth, very hard to smile. I have spots all over my forehead and a few on my cheeks. It’s always a shock to see my face in the mirror. But without looking at myself it feels like I put on one of those peel off face masks just tight. So far I sleep just fine. I don’t however use Vaseline I use calendula it’s for burns and has worked well. I have also used makeup when I had to go out in public. It is definitely convenient being in lockdown because everyone is wearing a mask so it hides my super red chin. I have 6 more days of cream, I am taking this one day at a time. The only side effect so far that I have had is two different days I felt extremely tired.”

8 / 10
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Caroline B · May 2, 2016

Efudex (fluorouracil) for Basal Cell Carcinoma: “This is my third time over the past 10 years doing this treatment. I'm scheduled for 4-6 weeks treating my legs, stomach and chest areas. I like that the medication seeks out and treats damaged skin only. My stomach has only 3 small spots. However my legs and chest area that have been far more exposed to sun have a much more aggressive reaction. The pain, redness, swelling and sores are extremely painful however my history reminds me that in 3-4 weeks I will be finished and my skin will look and be much better. Skin cancer gone and baby smooth new skin. It's affordable, and a more complete overall treatment that definitely works. Stick with the plan you don't be disappointed !!”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.