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User Reviews for Fluorouracil

Also known as: Carac, Efudex, Efudex Occlusion Pack, Fluoroplex, Tolak

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Fluorouracil.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Keratosis 38 reviews 17 medications
   
8.4
Skin Cancer 18 reviews 2 medications
   
8.2
Basal Cell Carcinoma 15 reviews 6 medications
   
7.7
Actinic Keratosis 21 reviews 8 medications
   
6.7
Warts 1 reviews 30 medications
   
1.0
Summary of Fluorouracil reviews 93 reviews 6.4

Reviews for Fluorouracil

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For Keratosis: "Fluorouracil worked fine on the AKs and wasn't as bad as I thought it would be except I experienced "hand foot syndrome"---burning of palms of hands and soles of feet (even though the medication never touched those areas)."

   
3.0

Anonymous June 13, 2017

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Efudex (fluorouracil) for : "Using this caused my lips to bleed and all the skin on my lips turned black and it was like acid eating at my lips! I was not men remotely able to find any pain relief. From Oxycodone to Dilauded the ER docs could not help me! Nothing worked so I was sent to a pharmacist which makes compounds. We spent 3 hours we experimented with different lidocaine solutions. The raw pain even with the lidocaine was so intense that I lost my breath and couldn't breath. Very scary but with this pain of simply flesh eating my lips I was not aware that pain could be this bad! I am a trauma nurse and nothing prepared me for this! Any suggestions out there! I wake in a pool of blood and I am starting to see a little improvement!"

   
1.0

annmarmacgmail.com June 10, 2017

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For Actinic Keratosis: "Given Rx due to pre-cancerous spot on side of face. So far, I have had no side effects. I am day 11 of 14 day treatment. No redness, no peeling."

Char - Tampa June 2, 2017

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For Actinic Keratosis: "I am 59, redhead, green eyes. Live in AZ. Not a sunbather. Under dermatologist directions used 5% cream for 10 days on forehead and chest. Very painful. Developed severe allergic reaction with swelling in face, lips, throat, fever, chills. Stopped treatment and narrowly avoided hospital. Still experiencing pain. Be careful!"

Miloo (taken for less than 1 month) May 17, 2017

1 users found this comment helpful.

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For Actinic Keratosis: "I used it once a day for 13 days and took two days off, I'm wondering if it's ok to start again or not. I was supposed to go 4 weeks. Anyone have any comments?"

   
9.0

Jakeslicks (taken for less than 1 month) April 30, 2017

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For Keratosis: "My first time using this cream and man it's no fun but it's effective. I apply it twice a day on my forehead and the left side of my face. About 10 days later now it's pretty red an peeling in places. Hope I won't have to take time off work. Don't think my hat will cover it up enough soon as a delivery driver. I'm only 31, I'm to young to be having these problems."

   
9.0

Jplysy April 21, 2017

4 users found this comment helpful.

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Efudex (fluorouracil) for Actinic Keratosis: "I used efudix for 20 days. Got all the bearable symptoms of rash, redness and sore skin. It took about 2 months for the redness to go completely. The main long lasting side effect I have is that it's been six months and I still have permanently very greasy, greasy skin on my nose and cheeks where I applied it. TIP, make sure you are not prone to rosacea before using it. I didn't know I was prone but the efudix triggered the adult rosacea I never knew I had. (rosacea is like acne, it comes and goes but only in the place where I used the efudix, it's embarrassing and I don't like going in public during flare ups.) I wouldn't recommend this treatment at all. It might be ok on small 2cm spot treatments on the body, NOT THE FACE. Beware"

   
2.0

Lough March 31, 2017

6 users found this comment helpful.

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For Basal Cell Carcinoma: "Had a basal cell right under my eyelid. My dermatologist insisted I go see a Mohs surgeon. I took a doctor (Internist) in my family with me to see the surgeon. The surgeon wanted to cut. When the internist told him that there is very little tissue under my eye and I could lose my eye he said well there is always a chance. The internist said how about fluorouracil? He said NO. Of course he said no - he is a surgeon and only makes his money on cutting. The internist wrote the prescription for 0.5% fluorouracil cream. To use for 3 weeks - apply at bedtime. After 2 weeks the area was very red and oozed and swelled up. I continued for the 3 rd week. It has been 10 weeks since I stopped the cream. The basal cell is gone and the area is just a little pink."

   
10

Carol A February 21, 2017

11 users found this comment helpful.

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Carac (fluorouracil) for Actinic Keratosis: "I have extensive AK on my face & chest and have had 5 Basal Cell & 1 Pre Melanoma lesions removed via surgery. Because of the extensive AK & my history - my Derm tried Blue Light (Levulan). I only made it 8 minutes & had 2nd Degree burns. Due to my reaction my Mohs Surgeon recommended Carac in a modified application as I am in sales. I use the cream 7 days then am off 3-4 wks. I plan by time of year & my schedule as you can't be in the sun. The Carac cream has been AMAZING!! I put it on before bed. I documented my reaction and have found that about Day 6 I can see red trouble spots, Day 7/8 itching, Day 10 scabbing. Overall my AK has diminished by 80% after 4 cycles since last spring. I took summer/fall off."

   
10

MBFitz (taken for 6 months to 1 year) February 6, 2017

15 users found this comment helpful.

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For Actinic Keratosis: "This is the fourth or fifth time I've used Flouracil the past thirty years or so. I'm sixty four, have spent a lot of time in the sun, with a lot of exposure on my arms and face. I started at age 35, the first time on my face, and went back three more times over the next twenty years, strictly on my face, ears, and back of hands. The first time, I freaked out after a couple of weeks. But after the four week treatment, it peeled off and my skin underneath came in baby butt smooth. I'm doing my arms now (hint: always do this in the depths of winter) but my arms were really damaged, and it's been almost five weeks now. I look like I survived Chernobyl and long sleeve shirts hide it. I really recommend this for a widespread treatment."

   
8.0

Dickiesmith6452 February 3, 2017

10 users found this comment helpful.

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Carac (fluorouracil) for Basal Cell Carcinoma: "A few months after one basal spot on my nose was removed with Mohs surgery and plastic surgery to correct the dime sized divot, my dermatologist prescribed Carac for three weeks applied once a day to my nose. I had read many reviews/experiences and dreaded starting the prescription. Thankfully I had very little reaction with only one spot that appeared like an irritated white head and that drained and disappeared after about 3 days. The rest of my nose, although a little dry, had no reaction at all. I will say my stomach was a little sensitive about an hour after I applied the lotion for a couple days so I made sure I drank plenty of water and ate something within the hour or so of applying it."

   
9.0

Gigi Robin January 18, 2017

4 users found this comment helpful.

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Carac (fluorouracil) for Skin Cancer: "10 days into the treatment and my face is borderline unsightly. Had to stop the treatment on my chest because it started scabbing. Just hoping it starts flaking soon as expected! Major pain on my chest when I took it starting around day three. Have not experienced much pain on my face just a little bit of tightness and itching. Trying to avoid putting moisturizer and make up on as my dermatologist says it will slow the healing. That is probably the worst part so far!"

Jiggy1025 January 17, 2017

9 users found this comment helpful.

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Tolak (fluorouracil) for Actinic Keratosis: "Used it for 4 days and no results whatsoever. Typical 5% Fluorouracil Cremes show at least redness. Tolak has shown none. More so, the formulation of it is horrible in that there are little white clumps Right out of the tube that make application difficult. The manufacturer offers hugely discounted coupons. You're better off buying the generic for better results."

   
3.0

SkinCancer (taken for less than 1 month) January 6, 2017

6 users found this comment helpful.

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For Actinic Keratosis: "I had extensive AKs for the past10 years on my forehead, scalp, temples, face and hands. Regular liquid nitrogen treatments removed those which were visible. They would return and other unseen AKs would appear. I wanted more effective treatment so I did almost 3 weeks of heavy applications of fluororacil 5%, 2x/day. The burning, blistering, cracking, stinging and swelling is most impressive. After nearly 3 weeks, my derm said I was done and it would take 2 weeks to improve alot, and 4 to be all better. He was right. My skin is great now, looks good and no AKs! It's miserable getting there but less cancer risk - why wouldn't you do it?"

   
9.0

Sladep (taken for less than 1 month) November 20, 2016

29 users found this comment helpful.

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For Basal Cell Carcinoma: "Why shouldn't you use this stuff after a shingles vaccine? I got the vaccine and started using fluorouacil 2 days later! My doctor never said anything. Anyone have an answer? I'm still using it and don't seem to be having any worse symptoms than I did in 2008. Although, I DID have a pretty bad reaction to the vaccine......"

   
6.0

betterhalf (taken for less than 1 month) November 13, 2016

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For Actinic Keratosis: "Worked fine in two weeks of 2x per day application in my bald head. However some AKs returned. Starting treatments again."

   
7.0

Goat21 October 31, 2016

7 users found this comment helpful.

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For Actinic Keratosis: "I was prescribed fluouroucil for actinic keratosis, used it on my face, was told any redness, etc. would be temporary. That was four years ago. I'm permanently scarred w/ a few pock marks, particularly around the mouth. My face skin is now so much more sensitive than it used to be. Below my chin also gets red super easy, like if I just rub my hand across that area once or twice. (I later read a dermatologist say that he recommends excluding the chin area from treatment.) The one actinic keratosis on my nose had been removed and this was a prophylactic use. I'm very sorry I used this on my whole face. As far as being effective, I can't really say, because I'd be speculating as to if I would have gotten more or not."

   
3.0

NotForMe (taken for less than 1 month) October 29, 2016

5 users found this comment helpful.

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Efudex (fluorouracil) for Basal Cell Carcinoma: "I have basil carcinoma of my face cheeks and face had lumps. I have Scottish skin. Started Efidux treatment and after day 3 I became violently ill. For 10 days I couldn't hold any food down what ever. Both exit body points were hammered with oozing duck poo like stuff I have never experienced before. Bloated stomach, gas build up and always on the toilet. After day 10 the systems eased and I started to hold some food down. Currently on day 16 of treatment an day face looks like an iron has been applied to both FACE CHEEKS. Very painful and still feel unwell. This better work because I have researched this product before commencing and there were no side affects listed like I have had. Met another patient of efidex with similar side effects."

   
5.0

Rackoon. (taken for less than 1 month) October 20, 2016

13 users found this comment helpful.

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For Actinic Keratosis: "On day 17 of 25 day Efudex fluorouracil 5% cream treatment on entire face, once a day, in the morning. Redness started on day 5 and now I am very red, face feels tight and dry. Some slight itchiness but not too uncomfortable. Bottom lip feels chapped. Face looks awful. Use cortisone cream at night. Fair skin, never tan, only sunburn."

   
10

Anonymous (taken for less than 1 month) October 18, 2016

9 users found this comment helpful.

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Carac (fluorouracil) for Actinic Keratosis: "21 day treatment. This stuff is brutal but it works. Make sure you give yourself a full two months for treatment and recovery. This treatment is lengthy and there is a process to it. Try to plan your treatment in the winter or fall months when its cooler. Believe me you will not want to go outside. Your face will be unsightly and you will become sensitive to the sun. Use the medicine at night and aquaphor during the day or at least two hours after you apply the cream. Cool the cream in the refrigerator for a bit for instant relief. You WILL get itchy. I used a q tip dipped in aquaphor to gently relieve the itchy. Be careful around the crevices by your nose. You don't want cream to accumulate there. Hang in there."

   
9.0

Julie from Tucson October 17, 2016

28 users found this comment helpful.

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Efudex (fluorouracil) for Keratosis: "Have used it for pre-cancer on my face probably 6 times since 1996. Using it now on a couple of spots on the back of my hand. Have always found it perfectly effective. Yes, after a couple weeks it begins to look raw and ugly, but that quickly clears up after treatment stops. In every case the spots were cured. Luckily I have never experienced any of the pain or itchiness that others have reported. Perhaps mostly the ones who had problems bothered to report? And I still have the original tube of the produce I got back in 1996, and yes, it still works. There was enough in it to keep me going when needed it and obviously it didn't go bad. The fact it's in a metal tube may have enabled it's long life vs a plastic tube."

   
10

Wayne from NS Canada (taken for 10 years or more) August 30, 2016

55 users found this comment helpful.

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Efudex (fluorouracil) for Basal Cell Carcinoma: "I have BCC on my upper arm and SCC on upper left hand. Unfortunately after 6wks of treatment twice a day the cream didnt work. So disappointed and im now scheduled to have both surgically removed."

   
1.0

Smand (taken for 1 to 6 months) August 30, 2016

13 users found this comment helpful.

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Efudex (fluorouracil) for Basal Cell Carcinoma: "I had a small lump removed from below my lip, and was prescribed efudex to be applied twice a day for four weeks. I have just finished that time, so I don't know how effective it has been. I had no reaction for 9 days, then my lip became very swollen and weepy, cracked in the corner. My GP suggested that I put vaseline around the spot before applying the cream, and that helped the lips considerably. I changed to paw-paw cream, which seemed to help. Now it is six days since I stopped applying the cream and I still have what looks like a large cold sore, as well as the red crustiness under my nose which started only when I stopped the efudex. I am hoping this may go soon. I am not sure whether to put anything on them or not."

   
7.0

Jojill (taken for less than 1 month) August 21, 2016

20 users found this comment helpful.

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Tolak (fluorouracil) for Actinic Keratosis: "I have used this cream for 5 days for pre-cancerous spots. Nothing is happening so far."

   
1.0

Sahar123 (taken for less than 1 month) July 29, 2016

13 users found this comment helpful.

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Efudex (fluorouracil) for Actinic Keratosis: "Dear the a: I have widespread actinic keratosis on my forearms. I was prescribed Efudex. I have thin, fair skin and some freckling. The damage seems to have occurred from a childhood playing outdoors, before sunscreen became so important. The Efudex, astonishingly, did nothing. So very disappointing. The dermatologist was equally surprised, and prescribed another round. Still nothing. And no one can give me an answer. I am now considering a chemical peel or whatever the next step might be. So very tired of hiding my arms. Good luck to you. If anyone can give you an answer, please, please post it here."

   
1.0

the b1 (taken for 1 to 6 months) July 28, 2016

23 users found this comment helpful.

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