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Klisyri Ointment

Generic name: tirbanibulin topicalTIR-ban-i-BUE-lin-TOP-i-kal ]
Brand name: Klisyri
Drug class: Topical antineoplastics

Medically reviewed by Judith Stewart, BPharm. Last updated on Mar 13, 2024.

What is Klisyri ointment?

Klisyri ointment is a microtubule inhibitor for use on the skin. Microtubules play a key role in cell division.

Klisyri ointment is used to treat actinic keratosis, a skin condition caused by damage from repeated exposure to ultraviolet light from the sun and/or indoor tanning.

Klisyri is used to treat actinic keratosis on the face or scalp.


Do not use Klisyri ointment in, around, or near your eyes, mouth or lips.

It is not known if Klisyri ointment is safe and effective in children less than 18 years of age.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Tell your doctor about all other medicines or treatments you are receiving to treat actinic keratosis. You may need to delay starting Klisyri until your skin has healed from other treatments.

Tell your doctor if you have other skin problems in the areas you will treat with this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Klisyri oitnment is not approved for use by anyone younger than 18 years old.

How should I use Klisyri ointment?

Use Klisyri ointment exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Do not take by mouth. Topical medicine is for use only on the skin. Klisyri is for use only on the face or scalp.

Klisyri is usually applied once per day for 5 days in a row. Follow your doctor's dosing instructions very carefully.

Wash your hands with soap and water after applying this medicine.

Apply only enough Klisyri ointment to cover the skin area affected by actinic keratosis.

Do not cover the treated skin area with a bandage.

Try not to get Klisyri ointment on other skin areas that are not affected by actinic keratosis. Rinse with water if this medicine gets in your mouth or on your lips.

Avoid washing or touching the treated skin for at least 8 hours after applying this medicine.

Each single dose packet of Klisyri is for one use only. Throw away the packet after use, even if there is still medicine left inside.

Store at room temperature away from moisture and heat. Do not keep this medicine in a refrigerator or freezer.

Dosing information

Usual Adult Dose for Actinic Keratosis:

Evenly cover up to 25 cm2 on the face or scalp once a day

-Treat for 5 consecutive days using on single-dose pack per application.
-For topical use only; not for oral or ophthalmic use.

Use: For the topical treatment of actinic keratosis on the face or scalp

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe skin reactions (redness, swelling, blistering, peeling, crusting, oozing, ulcers).

What should I avoid while using Klisyri?

Do not get Klisyri ointment in your eyes. If contact does occur, rinse with water and call your doctor right away.

Rinse with water if this medicine gets in your mouth or on your lips.

Do not share Klisyri with another person, even if they have the same symptoms you have.

Klisyri side effects

Get emergency medical help if you have signs of an allergic reaction to Klisyri: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common Klisyri side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Klisyri?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Klisyri ointment only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.