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User Reviews for Fluorouracil topical to treat Keratosis

Also known as: Efudex, Carac, Fluoroplex, Efudex Occlusion Pack, Tolak

Fluorouracil topical has an average rating of 7.9 out of 10 from a total of 60 ratings for the treatment of Keratosis. 78% of reviewers reported a positive effect, while 15% reported a negative effect.

Fluorouracil topical Rating Summary

7.9/10 average rating

60 ratings from 67 user reviews.

Compare all 32 medications used in the treatment of Keratosis.

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Reviews for Fluorouracil topical

BQ · Taken for less than 1 month April 25, 2020

Efudex (fluorouracil): “I'm a 68 year old male. This is the second time I have used this fabulous cream. Enjoy the results, YES! Enjoy the experience, NO! I applied the cream twice a day to my entire face for two weeks. After two further weeks, all of the scabbing has gone and my face has peeled. Still a few weeks to go before the worst of the redness goes. I must be honest - the pain was bad: Burning sensation, needle pricks, scabbing and blood spots on my pillow. Sometimes it was so bad, I had to ease the pain with ice. But all of the pain described above was worth it. The cream detects the worst affected areas - some I had no idea were damaged. It leaves the undamaged skin alone. This cream has reduced my number of visits to the seriously expensive dermatologist to almost zero. My skin feels and looks twenty years younger. I cannot recommend this cream enough, You should be thrilled with the results. But, as with most rewards in life, there is some serious pain involved.”

10 / 10
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Anna · Taken for less than 1 month October 13, 2020

Efudex (fluorouracil): “I’m 52 yo sun loving female and started treatment of Efudex. I’m 3 weeks in and last dose on day 20. I didn’t react too badly to start at all. 3rd week in saw big changes as skin became more inflamed but very manageable. I was anxious with all the reviews I read but think it’s important to remind ones that everyone is different. The last day and night after finishing has been the most painful. I’m Putting 1% hydrocortisone on in ointment form. Keeps area oily Some benefits of COVID are mask wearing. With hat sunnies and mask I can go out and people don’t notice how hideous I look. Taking pain relievers to sleep. Itching, burning at night is worst. I’m a runner and I’ve continued all the way thru but will see what the next few days brings.”

9 / 10
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JG · Taken for less than 1 month May 2, 2020

Efudex (fluorouracil): “This is my second time around for using efudex. The first time was 6 years ago. I've grown up on the West coast and spent my summers in the deserts or at the beach. I am of Irish descent, brown hair, blue eyes. By the time I was 60, my face looked terrible. High danger for skin cancer, many trips to dermatologist. Began to hurt significantly on day 14. Everything I read and saw on the web said "stick it out". I made it to day 25, Couldn't do another minute. Dragged myself into the doc's office on a Friday afternoon. I looked like Frankenstein. Appt's clerk gasped. Doc said "Great job. Looks like it was very effective." That night I washed everything off, and applied Aquaphor. Next two days were most painful. After that, it got better every day, and within two months, there was no trace of the 40 years of sun damage on my face. So...I would give this a 10. I'm a teacher, and did the treatment over the winter holidays. It was all done by January 7”

10 / 10
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j mack · Taken for less than 1 month September 27, 2015

Efudex (fluorouracil): “This is the best!! I've been using it for 4 years and it is absolutely the best solution for AK's. I am 60 years old, fair skin, been outside for years and developed way too many AK's, not to mention basal and squamous problems too. For years, the dermatologist only used spot nitrogen and prescribed caramac. I can only assume she didn't prescribe efudex because she needed the steady income stream from me and my insurance. By chance I was having a physical from my family doctor. He asked me when I was going to address my AK;s on forehead. I told him I did, and he told me he could write me a prescription for medicine that solves it, efudex. He did and I amazed at the ending results. Yes, the efudex was painful, looked bad when it was working but results speak for them self”

10 / 10
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Rankin · Taken for less than 1 month October 29, 2019

Efudex (fluorouracil): “Put it on the obvious parts of my face that I thought needed to be treated, found that the Efudix somehow seeped to cover much more of my face, had lots of redness followed by crusty scabbing, had to stop treatment after just short of 3 weeks as my eye were in agony with stinging gritty feeling, even though I didn't put any anywhere near my eyes - wonder if gets into sinus system and makes its way there.”

9 / 10
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ford6970 May 14, 2015

Efudex (fluorouracil): “I am now into my 15 day of using the efudix cream and I look scary I was told by my skin specialist to do my whole face and as directed have done so .I am a 51 year old woman that grew up on the coast and never thought any thing of it. After having a melanoma removed last year the ugliness ,pain and itchiness of this treatment is far better than a alternative outcome .Like others googled pictures and was horrified but remember the out come will be beautiful I would do it again in a heart beat.”

9 / 10
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Richard - NC November 14, 2010

Efudex (fluorouracil): “I'm an engineer, now in my 60s, and I have worked outside all my life. I have red hair and fair complexion you can imagine the skin damage I have accumulated in my lifetime. I had used the Efudex 5% cream years ago and had good results. Three months ago I began seeing a dermatologist that recommended the "new" technology "BLUE LIGHT TREATMENTS". This did NOT work for me gave me a very mild "sunburn" with no apparent effect on the former skin damage and it was very expensive even after insurance coverage! I requested my treatment be changed to the proven Efudex my doctor insisted I stay with the "blue light", that my skin was "in very good condition" and that I only needed "maintenance". As you may guess I have changed physicians and now I am being treated with Efudex again. My skin is now in full reaction after only two weeks treatment with Efudex. Yes with Efudex your skin is unsightly and uncomfortable from week 2 through to week 4; but, this is a small price to be cancer free. Efudex works! ”

9 / 10
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Wayne from NS Canada · Taken for 10 years or more August 30, 2016

Efudex (fluorouracil): “Have used it for pre-cancer on my face probably 6 times since 1996. Using it now on a couple of spots on the back of my hand. Have always found it perfectly effective. Yes, after a couple weeks it begins to look raw and ugly, but that quickly clears up after treatment stops. In every case the spots were cured. Luckily I have never experienced any of the pain or itchiness that others have reported. Perhaps mostly the ones who had problems bothered to report? And I still have the original tube of the produce I got back in 1996, and yes, it still works. There was enough in it to keep me going when needed it and obviously it didn't go bad. The fact it's in a metal tube may have enabled it's long life vs a plastic tube.”

10 / 10
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FanchonLinda June 2, 2015

Efudex (fluorouracil): “I have done this Efudex treatment three times over a 20 year time span. It is a hideous process but it beats the alternatives! KNIVES cutting you up in particular. I use and recommend AQUAPHOR instead of the expensive prescribed cortisone cream for a quicker more effective healing process. I think EFUDEX is Great!”

10 / 10
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pdxbuc August 9, 2010

Carac (fluorouracil): “Just finished my 4 week course of Carac cream. Here is my advice. MOISTURIZE, MOISTURIZE, MOISTURIZE! I went to Rite-Aide and purchased a large bottle of Vitamin E and ALOE gel moisturizer (nothing with alcohol, which will burn or oil, which is difficult to remove) as well as a bottle of Baby Wash (you know, "no more tears"). Only wash your affected area (mine was face and scalp) with the baby wash (doesn't dry out skin) and once the Carac has been applied, wait about 1/2 hour and begin applying the moisturizer. I used the moisturizer heavily 5 or 6 times per day. It soaked right up and worked great. Felt like a light sun-burn with moderate peeling and when I was done and I healed up in a snap.”

10 / 10
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Largo7 March 5, 2013

Efudex (fluorouracil): “Used the product on my face for 6 weeks twice a day for two days every week. Depending on the extent of sun damage, the effects are dramatic and nasty looking. After the 2nd week the treated area looks like a bad sun burn, it itches, peels, weeps, bleeds and burns. But the results after stopping for 3-4 weeks are very good.”

8 / 10
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Simon · Taken for 10 years or more June 16, 2019

“I have been using this off and on for a long time. The part that puzzles me is people just applying to their whole faces, lesions or not, I’ve never done that. Little rough looking red patches show up and I know that’s a pre cancerous lesion and apply the cream just to that area to kill it. If you catch it immediately, it only takes like 3 times a week for a couple weeks. Why would you draw them up and make your face a mess? I spot treat and it works quite well. If you catch early as soon as they pop up much less aggravation with the treatment.”

8 / 10
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Sargie56 October 7, 2017

Efudex (fluorouracil): “I was diagnosed with actinic keratosis in August and then decided to apply the Efudex cream to face in the middle of September. I thought that I only had a couple of spots which I was concerned about but after applying the cream to my forehead, temples, cheeks, nose, around the eyes and my ears it became quite apparent that there were a vast amount of areas that had been affected. In the First week I saw that these areas became inflamed although not painful. In the second week these areas started to merge together and then look like blisters and sores on my face, especially below my eyes. In the third week these started to scab a little and became a bit painful I think due to the skin feeling very dry. I am now in my fourth and final week”

10 / 10
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froghopper1 November 19, 2009

Efudex (fluorouracil): “This is my second time around with Efudex. I swear by it for effectiveness. Side effects are bad: breaking out looks unsightly, itching makes you feel like you want to scratch off your skin. The best relief I have found is Tylenol for pain and Calendula Cream (Marigold Cream) for the relief of irritated skin. That's keeping me sane and I am on week 4 overall: 16 days using medication the remainder trying to overcome side effects. Good luck to everyone. I still have more to go....”

9 / 10
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urphotoguy July 12, 2009

Efudex (fluorouracil): “Efudex works great but is very painful and itchy after about two weeks. I tried many creams to relieve the symptoms between applications of the Efudex. One cream that REALLY helped was Traumeel. What a sanity saver. Just thought I would pass this on for others to get some relief. I hope it can help you too.”

10 / 10
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Joffa · Taken for 6 months to 1 year August 27, 2019

Efudex (fluorouracil): “Treatment with efudex on both arms for keratosis, caused damage, had bad reaction creating auto-immunity situation; still being treated by dermatologist after 12 months. Itching unbearable on arms, bleeding after scratching and left with watery mess. Relief from ice-packs help and then moisturising. Treatment from Prednisolone, Cyclosporin lasts for a few weeks and then I break out again. Been around this way 6 times now! Efudex: seek all the info you can before treatment.”

1 / 10
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Oilpainter December 25, 2014

“I was on Fluorouracil two times a day for two weeks. It wasn't too bad for the first 10 days then it continued to burn more with every application. The most painful part of the Fluorouracil treatment was after I completed the applications. A nurse recommended that I mix %u2153 cup of white vinegar with 6 cups of water and place the mixture in the refrigerator until chilled. Then, use a very soft wash cloth and the vinegar solution to cleanse my face. She also said to take the damp wash cloth and place it over my face for 15 minutes 4 times daily. Contrary to what I thought, the vinegar solution did not burn, it soothed incredibly.”

10 / 10
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Lindy · Taken for less than 1 month September 26, 2020

Efudex (fluorouracil): “I am a 70 year old woman originally from Britain..used efudex on chin, side of nose and cheek. Went up a little too close to corner of my eye which swelled up. I used twice a day for 15 days which was enough to bear. Big crusty scab on chin. Very sore itchy and burning. Can't do the other side of nose as too painful.”

10 / 10
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day14 December 29, 2009

Carac (fluorouracil): “I am on day 14 of using Carac. My face is extremely red, tight, itchy and a little sore, but I've had serious eczema in the past and this isn't nearly as bad as that was. It took about a week to show up on my forehead but then a couple more days they started intensifying on my cheeks, chin and sides of my face. It is a little unsightly but once I explained to people what was going on and that it wasn't permanent or contagious they seemed to relax. I tried Vaseline for moisturizing but that seems too greasy. Products with zinc oxide in them seem to give me relief and protect me from the sun as well. Please do not spend ANY time in the sun when using this. The doctor told me it could permanently make your skin darker in those areas!”

8 / 10
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Anonymous September 29, 2010

Carac (fluorouracil): “I just finished a 14 day usage of Carac, as prescribed by my skin doctor. After the first two days my skin started to turn red, by the 7th it started to flake and the areas that I needed to apply it to ( cheeks, temples and forehead ) turned dark red, like a bad sunburn. Days 8 -14 were the worst as to pain on these areas when showering in lukewarm water or washing from sink bowl, either way I could feel a burning sensation, as well as light bleeding at some areas on the next to last day. Flaking of skin and itchy feeling now that treatment is done. I wonder how long before my skin color returns to normal. Would I do this again? Yes”

9 / 10
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stillitchy · Taken for less than 1 month August 27, 2015

Efudex (fluorouracil): “Had very adverse reaction after 8 days of applying cream to chest ended up with severe open skin wounds needed antibiotics, lidocaine gel, silvadine creme, prendisone, oxicodone, altrax, and ambien to sleep sooooooo painful.”

1 / 10
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Anonymous · Taken for less than 1 month August 1, 2018

Efudex (fluorouracil): “Have been using efudex now for two weeks. I have been putting my regular moisturizer on every day and my skin stays soft. I use pure Shea butter. Having a little itching but not bad. I thought users might try Shea butter to help keep the area moist.”

7 / 10
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Madpeg · Taken for less than 1 month October 9, 2019

Efudex (fluorouracil): “Been using Efudex for 3 weeks now applying it nightly on a small spot on the left cheek, the area of skin been scaly now really red and has spread to double the size , I have stopped applying it as the soreness has gone and will wait a month to see if it clears , the treatment gave me a funny taste , dicky tummy and terrible itching on my back for ten mins after a bath or shower , scored 5 at the moment because my cheek looks a mess with the redness but hope it will clear over the coming weeks , applying sudacrem hope it helps !”

6 / 10
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island gal August 4, 2015

Carac (fluorouracil): “62 year old blonde with blue eyes and fair skin. Spent 50 years in CA and HI getting sunburned. Now....paying the price. I have used Efudex and Carac cream treatments, both burn like crazy, peeling several layers, and red, red, red. I did my whole face at one time, but had to stop after 18 days applying once a day. Had blisters and bleeding, crying quite a bit. It took two months after stopping the treatment for the pinkness to disappear. Using sf 50 every day now under my makeup. Get lots of compliments on how young my skin looks. :o) Now I am doing my chest. ten days into the treatment with 18 day plan. Not as painful as my face since the skin is thicker. Still very red and starting to peel today. Using ibuprofen.”

10 / 10
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Anonymous November 8, 2009

Efudex (fluorouracil): “I tried the Traumeel another user suggested. It did nothing to help with the pain. The only relief I have found so far is Tylenol, Extra Strength and Aquaphor once everything has been pulled to the surface. Of course keeping the affected areas uncovered is a huge help. I sleep on a beach towel over my sheets so the shedding and peeling are "contained". It's the only way I don't itch throughout the night and even if I do, the roughness of the towel helps to get it off the skin. Hope this helps. ”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.