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Fluorouracil Topical Dosage

Medically reviewed by Last updated on Aug 30, 2022.

Applies to the following strengths: 5%; 2%; 1%; 0.5%; 4%

Usual Adult Dose for Keratosis

0.5% cream (microsphere formulation): Apply to the affected area once a day where actinic keratosis lesions appear, using enough to cover the entire area with a thin film

1%, 2%, 5% cream or 2%, 5% solution: Apply 2 times a day in an amount enough to cover the lesions; continue until the inflammatory response reaches the erosion stage, then discontinue use


Use: For the topical treatment of multiple actinic or solar keratoses

Usual Adult Dose for Basal Cell Carcinoma

5% cream or solution:


Use: To treat superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:


Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.