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Imvexxy and Headaches: What Users Say

Headaches: mentioned by 12 users (16.9%)

Based on user experiences from 71 Imvexxy reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 16.9%
hair loss 14.1%
cramps 11.3%
hot flashes 7.0%
night sweats 7.0%
discharge 5.6%
itching 5.6%
migraine 5.6%
rash 5.6%
swelling 5.6%

Reviews for Imvexxy

Commonly mentioned side effects
  • Lea...
  • Taken for 6 months to 1 year
  • November 13, 2020

For Atrophic Vaginitis "I have been taking Imvexxy 10mg twice a week for about 10 months now. I had dryness on the outside of my personal area, more so than the inside dryness. I'm 64 with a healthy sex life. My husband thought it made me too lubricated and he didn't care for it. After two months, I noticed night sweats and some hair loss along with slight headaches. Mostly the night sweats were my big problem. I adjusted to 1 time a week of the 10mcg for a month, but still had night sweats. Now, I have been totally off Imvexxy for two weeks and noticed the night sweats have lightened up a bit. I am going to continue to stay off for 6 weeks to see if there is a big difference with the night sweats, hoping they disappear completely. I did not have this problem before I was on Imvexxy. The reason I was checking out these reviews was to see if anyone else had these same side effects. Please let me know if you do."

8 / 10
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92 Report
  • Kim...
  • September 16, 2020

For Atrophic Vaginitis "After dealing with atrophy following a total hysterectomy, my doc suggested Imvexxy. Let's start with the positives: It DID what it was supposed to do, painful sex vanished after using it only a week and a half and I felt better in the nether regions. Now for the 'not so' positives: I noticed my hair thinning and had a slight headache. In the second week, I noticed a rash on my arms (elbow down) and legs. My family doc treated me with steroids, but it started right back following treatment. I decided to stop Imvexxy on a hunch, and after nearly two weeks, the rash began to fade. When I mentioned this to my gyn, she said you must be allergic to coconut oil... I use coconut oil every day with no issues. The ONLY thing different before all this mess was starting Imvexxy. Bottom line, if anyone did have a rash after this medication and was told 'That's not the cause.' by their doc, you are not alone. I am trying another (non-hormonal) product as it had some good reviews... just to see."

4 / 10
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67 Report
  • Sas...
  • Taken for 1 to 6 months
  • February 13, 2020

For Dyspareunia "I have been taking Imvexxy 10 mg twice a week for 6 months now at night before bedtime. It has not helped at all with painful intercourse and dryness. My dr told me not to expect instant results and to try it for a few months. I had also hoped for at least a small bump in libido, but nothing. I usually get a slight headache the day after using, and there is some external burning as well. My hair feels thinner. I don't like having to insert the capsule manually; it's awkward and I never feel that I've inserted it far enough. Have not had any of it come out, though. I also feel that I may be starting a yeast infection. This is not for me, and I will discontinue after this month."

1 / 10
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64 Report

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Frequently asked questions

  • ABK...
  • Taken for less than 1 month
  • December 24, 2020

For Atrophic Vaginitis "My Dr. wanted me to take this every night for two weeks. I had to discontinue use after 4 nights. When I would get up in the morning, there was so much discharge. I had a horrible headache the entire four days that I took it. It made my rosacea flare up. I felt tired and run down, and my body felt sore."

3 / 10
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41 Report
  • Tam...
  • October 12, 2020

For Atrophic Vaginitis "I’m 51 and been in menopause for a few years. Imvexxy and progesterone 100 mg have helped me 100 percent! I have been taking both for 2 weeks, and intercourse is comfortable and pleasurable. I had a few headaches the first week. No other side effects. My husband and I couldn’t be happier with the results of Imvexxy. He thinks my breasts feel larger than before too. Thankful customer."

10 / 10
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36 Report

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  • Swe...
  • Taken for 1 to 6 months
  • November 5, 2020

For Atrophic Vaginitis "I just started my 3rd month of using the 10 mcg insert of Imvexxy. The dryness has been completely reversed, which in turn stopped my chronic BV. Yay!! However, I've been feeling nauseous and crampy with a mild headache for the past 6 weeks. I also seem to be experiencing more hot flashes and night sweats. I don't want to believe it's the Imvexxy causing this and the low back pain, but since nothing else has changed, and I take no other medications, I can only assume it is the Imvexxy. I am almost 60 yrs old and have been in menopause for 8 yrs or so. I keep thinking these symptoms will go away, but they actually may be worsening. I'll likely finish using the rest of this prescription but not renew it."

5 / 10
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32 Report
  • Kat...
  • Taken for 1 to 6 months
  • August 21, 2020

For Atrophic Vaginitis "I tried Imvexxy for 4 weeks and then tried Intrarosa for 4 weeks and decided on Imvexxy. I have been on it for 2 months now and am very pleased. The first 2 weeks, I had a mild headache pretty immediately after using the drug, but thankfully I no longer have this side effect. A big bonus has been much better sleep since taking Imvexxy. The Intrarosa also worked for the vaginal dryness, but also was more cumbersome with daily usage requirements and also made it hard to fall asleep at night."

8 / 10
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21 Report
  • Reg...
  • Taken for 6 months to 1 year
  • November 7, 2021

For Dyspareunia "My physician prescribed Premarin vaginal cream, with good results. After a year, CVS, my prescription provided, notified me they would no longer cover any of the cost of Premarin and recommended the physician order Imvexxy 10 mcg twice a week. Even using this medication faithfully, I have had minimal to no improvement in the dyspareunia, and the residual headaches are miserable."

1 / 10
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6 Report
  • Anonymous
  • Taken for 2 to 5 years
  • January 29, 2022

For Atrophic Vaginitis "Prescribed to me for surgical menopause (hysterectomy in my 30s). Worked to help prevent UTI and vaginal dryness. Side effects: diarrhea, headaches, and body aches. Sucks… But big pharma keeps you coming back for side effects and other problems. Gotta keep you a customer, I guess. 4 mcg twice a week."

4 / 10
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5 Report
  • Kit...
  • April 1, 2020

For Atrophic Vaginitis "Started using Imvexxy 3 weeks ago. Cramps, headaches, and still encountering painful intercourse. I am 51... looking for relief... Insertion is a bit messy. I have stopped using as of yesterday..."

3 / 10
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24 Report
  • Joa...
  • December 28, 2018

For Dyspareunia "Had abdominal swelling and a headache right away; couldn’t tolerate it. Went back to vitamin E suppositories."

2 / 10
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24 Report
  • Cha...
  • July 27, 2019

For Dyspareunia "Did not work for me and gave me headaches."

1 / 10
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16 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.