Vyepti and Itching: What Users Say

• dov...
• Taken for 1 to 2 years
• November 6, 2021

For Migraine Prevention "I have chronic migraines, some of which are hemiplegic, and I have tried so many drugs that didn't work - oral preventatives, Botox, Emgality, etc. Vyepti is the only drug that has helped me at all. Due to my migraine severity, I get the 300 mg dose once every three months. Vyepti brings my head pain from an 8 down to 5, 6, or 7, depending on my menstrual cycle timing. I have far less hemiplegic migraine aura, so I only have full-blown body weakness and trigeminal neuralgia-like face pain at the end of my three-month Vyepti cycle. Pros: less head pain, less face pain, less severe aura, lasts months, manageable short-lived side effects, less painful than self-injected CGRPs, doesn't upset the stomach. Cons: due to my migraine frequency, it takes 1-2 weeks to kick in after infusion, 2 weeks of allergy symptoms after infusion (runny nose, sneezing, itchy eyes, nose, throat, fatigue), nausea after 300 mg infusion (easily fixed with IV Zofran, does not occur with 100 mg dose)."

• Ror...
• October 8, 2021

For Migraine Prevention "I started having truly bizarre side effects, like itching so badly I’m surprised I didn’t lose skin, being in a room that was 74 degrees (I’m from a state that’s hot nearly year-round), and sweat was just dripping off of me. In other areas, my skin was so dry I had to use lotion for diabetics. It was absolutely miserable! My insurance covered the medication, it is as positive as I can be."

• Cee...
• Taken for 1 to 6 months
• July 4, 2024

For Migraine Prevention "Just had my second Vyepti infusion, first of 300 mg, for chronic migraine. First infusion was in April of 100 mg Vyepti. Had mild itching on my face after 1st infusion. April was great, hardly any headaches. May was tough, had 10 headaches. After two headaches the first of June, the rest of the month was wonderful. My neurologist suggested I take a double dose of allergy medicine prior to the infusion. I did and had no side effects. Looking forward to no headaches this treatment period. I had good success with Emgality but insurance would no longer pay for it. But they do pay for Vyepti."