Vyepti and Headaches: What Users Say

• doe...
• Taken for less than 1 month
• June 8, 2023

For Migraine Prevention "Made everything worse. They claim only 2 people in the trials had worse migraines, that's a lie. My body was rejecting it as it was going in, yet they let it finish, and because it wasn't normal allergy symptoms, they just reported it and left me to suffer. Metal taste, extreme muscle spasms, thought it was a seizure, extreme muscle pain, 10/10 headaches nonstop. If other CGRP have not worked for you, do not take this."

• Dro...
• Taken for 6 months to 1 year
• December 30, 2022

For Migraine Prevention "This medication was very awful! I did three rounds of infusion over 36 months. First time 100 mg. Second and third 300 mg. The first month each time I felt crazy, anxious, my stomach hurt, and I had insomnia. Did not help with headaches. The second month each time anxiety lessened, but stomach pain continued to hurt and I had insomnia, headaches remained but were less painful. Third month headache worsened, and stomach pain and insomnia continued. This medicine was NOT helpful! I gave it a fair trial but cannot recommend this, in fact, I recommend you avoid this medicine. I was desperate enough to try it, but it was awful."

• Zsu...
• Taken for 1 to 2 years
• May 9, 2023

For Migraine Prevention "It is reducing my migraine attacks by 30-40%. The side effects for me are a runny nose and very high blood pressure. Normally my blood pressure is 90/60, after receiving the infusion, it goes up to 150/89 - this causes me very bad headaches."

• Sti...
• Taken for 1 to 6 months
• April 5, 2023

For Migraine Prevention "I told my first round of 100 mg on 2/26/23. Two days later, I began getting cold symptoms and sinus pressure and stuffiness. Six weeks later, I still feel stuffy and constantly blowing my nose. I woke up with a headache every day, which I wasn’t experiencing before, but I didn’t have any migraine symptoms for about five weeks. I do feel that it changed my mood. I was depressed or sad, but not happy either, just felt neutral. Still not sure how I feel about it. I may go back to Ajovy."

• Anonymous
• Taken for 1 to 6 months
• November 4, 2024

For Migraine Prevention "I just had my second infusion done on 11/01/24. Overall, it seems to be helping. I did notice towards the last month my headaches returned more frequently. Also, after receiving the infusion, I experience feeling very tired and nap on and off for the next 24-48 hours. I get a slight stuffed nose and sore throat, but that goes away after a few days. I’m feeling overall positive about this treatment plan."

• MKJ...
• Taken for 1 to 6 months
• July 22, 2024

For Migraine Prevention "I have had one infusion of Vyepti and my consumption of Sumatriptan has gone down drastically. I do have headaches, but they are much milder, and usually, I can skip the abortive medication. Side effects have not been an issue."

• cf2...
• Taken for 1 to 6 months
• March 14, 2025

For Migraine Prevention "Not sure I get anything from it. The first infusion, I got a worse headache on both sides of my head that lasted about 6 weeks. Nothing would help it. I just took a second infusion (I told the Dr. I would try it for a year), and I am having head pain again, and I am having problems with fatigue. Not sure I will make it to a 3rd try on this, but this was my last hurrah, so unless something else is created, I am at the end of the line."

• 123...
• Taken for 1 to 2 years
• May 20, 2025

For Migraine Prevention "Works well! 100 mg dose: much less constipation than Aimovig high dose. But when I switched to 300 mg, the constipation was so much worse! Fewer/milder migraines, though, so it’s worth it! Without preventative medications, I can barely work part-time. With Vyepti, I can have a career. Fatigue on the day of infusion every time, and sometimes headaches. Shoulder pain for a week following infusion. Been having a lot more nausea, joint pain (knees, back, elbows, shoulders), anxiety, and my hair is so much greasier. Some of this could also be hormonal, as I’m 48 and female."

• Amy...
• Taken for less than 1 month
• November 29, 2024

For Migraine Prevention "Got infusion this morning and triggered a headache, but dizzy. Putting it down to not sleeping well the past few days. I've tried most other drugs, if gets crossed for this one."