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Can Vyepti cause fatigue?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 15, 2024.

Official answer


No, Vyepti has not been shown to cause fatigue in clinical studies conducted by the manufacturer. Unusual tiredness or weakness may occur if you have an allergic reaction to Vyepti. Tell your doctor right away if you have these side effects during after Vyepti infusion.

How is Vyepti given?

Vyepti (eptinezumab) is given as an intravenous (IV) infusion in your doctor's office usually 4 times per year. You do not give this medicine to yourself. The infusion takes about 30 minutes and your healthcare provider will monitor you for any side effects. Once your infusion is done, you can leave the infusion center and continue your daily activities.

Vyepti is used to prevent migraine headaches in adults.

What side effects may I see with Vyepti?

In studies, the most common side effects that occurred in at least 2 out of every 100 patients (2%) were common cold symptoms like stuffy nose and scratchy throat and allergic reactions. Vyepti is typically well tolerated, with less than 2% of patients dropping out of research studies due to a side effect.

Allergic reactions were not frequent in research studies. In studies on over 2,000 patients, 1% to 2% of patients had an allergic reaction (also called a hypersensitivity reaction).

  • Some allergic reactions, such as anaphylaxis and angioedema, may be serious and or life-threatening and require immediate medical attention.
  • Most allergic reactions occurred during the infusion at the clinic, were not serious, but often led to discontinuation of the medicine or required treatment.
  • Inform your health care provider right away if you have any chest tightness, a cough, rash or itching, redness or flushing of the face, trouble breathing or swallowing, the development of large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, or unusual tiredness or weakness while you are receiving this medicine.

Let your healthcare provider know if you have any other side effects that won’t go away or are bothersome.

This is not all the information you need to know about Vyepti (eptinezumab) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.


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