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Vyepti (Intravenous)

Generic name: eptinezumab-jjmr (intravenous route) [ ep-ti-NEZ-ue-mab-- jjmr ]
Drug class: CGRP inhibitors

Medically reviewed by Drugs.com. Last updated on Feb 15, 2022.

Commonly used brand name(s)

In the U.S.

  • Vyepti

Available Dosage Forms:

  • Solution

Therapeutic Class: Antimigraine

Pharmacologic Class: Eptinezumab

Uses for Vyepti

Eptinezumab-jjmr injection is used to prevent migraine headaches in adults.

This medicine is to be given only by or under the direct supervision of your doctor.

Before using Vyepti

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of eptinezumab-jjmr injection have not been performed in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of eptinezumab-jjmr injection have not been performed in the geriatric population. Safety and efficacy have not been established.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of Vyepti

A nurse or other healthcare professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins. It must be given slowly, so the needle should remain in place for at least 30 minutes every 3 months.

Precautions while using Vyepti

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have chest tightness, cough, rash, itching, redness of the face, trouble breathing or swallowing, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, or unusual tiredness or weakness while you are receiving this medicine.

Tell your doctor right away if you are pregnant or planning to become pregnant before receiving this medicine.

Vyepti side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  • Chest tightness
  • fast heartbeat
  • feeling of warmth
  • fever
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • redness of the skin
  • redness of the face, neck, arms and occasionally, upper chest
  • swelling of the eyelids, face, lips, hands, or feet
  • trouble breathing or swallowing

Incidence not known

  • Cough
  • dizziness
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • muscle aches
  • sore throat
  • stuffy or runny nose

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Frequently asked questions

View more FAQ

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.