Enzalutamide and Hot Flashes: What Users Say

• Spa...
• Taken for 1 to 2 years
• June 14, 2019

Enzalutamide for Prostate Cancer "Apparently, have stage 4 prostate cancer. Had radiation, no surgery; went on Lupron for 2 years. Prescribed term ended and then PSA climbed in 3 months from 0.23 to 4-ish. Back on the Lupron. PSA dropped at first, then climbed to 6.4. Started Xtandi (simultaneously on Lupron) almost 2 years ago. PSA rapidly dropped to below 0.02. Been there ever since. No change in side effects from being on Lupron alone: Hot flashes (fewer and less severe over time) and weakness when they occur. Last 30' to a couple of minutes. For me it seems like a miracle drug."

• jlm...
• April 18, 2016

Enzalutamide for Prostate Cancer "4 months at 160 mg each day and 1 month at 120 mg a day. PSA was 48 when starting this medicine. PSA dropped to 0.20! Medication did its job. BUT, side effects were extremely painful, tiring, hot flashes, losing my balance, and so much more. I'm 83 years old and had stage 4 prostate cancer. If I get 4 more years or so, it's worth it. Have been off medicine for about 3 months and still having side effects! Rating would be 8."

• Ric...
• Taken for 2 to 5 years
• May 4, 2022

Enzalutamide for Prostate Cancer "I'm a 63-year-old male who was diagnosed with Stage 4 prostate cancer and started on Casodex/Lupron. It was good, but Casodex stopped working after 6 months. I was switched to 160 mg of Xtandi. Dropped my PSA pretty quick, side effects were pretty rough to start with (memory, brain fog, balance issues, hot flashes). After 6 months, the doctor lowered the dose to 80 mg, and side effects lessened. Brain fog reduced greatly, hot flashes and balance issues come and go. PSA has been non-detect for over 2 years now. I also take multiple natural supplements that I have researched. These supplements reportedly block the feeding pathways of my cancer. They can also help extend the effectiveness of the Xtandi. Do your research because the doctors don't look at anything natural. Also, change diet and limit carbs to 75 gm / sugar 40 gm or less. Lots of vegetables, a whole lot less meat. I have to say, I'll put up with the side effects as this drug really works."

• Doc...
• Taken for 2 to 5 years
• November 8, 2021

Enzalutamide for Prostate Cancer "I've been on Xtandi since May of 2019, along with a shot of Leuprolide every 3 months. I have been taking 4 - 40 mg capsules each day. My PSA almost immediately dropped to below measurable and has remained there. Side effects have been brief hot flashes, aggravated when I get in a warm room, some loss of muscle mass, and loss of taste so that favorite foods are no longer enjoyable. I do taste salt and sweet. I am 75, maintain a relatively active lifestyle, and consider my side effects minimal. I had high-risk prostate cancer and underwent a robotic prostatectomy along with adjuvant radiation. I started the Xtandi following the surgery."

• Ano...
• Taken for less than 1 month
• May 17, 2026

For Prostate Cancer "Headaches, vivid dreams, hot flashes from face to waist, stomach ache, constant nauseousness, constant bloating, slightly numb feet, itchy armpits. I've had to stop only 3 weeks in. I'm sorry, for some people it really is good. I haven't been able to take it because of the side effects. Also, I live alone and can't be sick all the time. The first week it was just hot flashes, which wasn't bad. But my third week I became very sick and had to stop. Can't say if it worked or not because I haven't had the PSA tests since taking it."

• Anonymous
• Taken for 1 to 2 years
• August 26, 2021

For Prostate Cancer "Had metastatic prostate cancer in my lung, three nodules. Been on Xtandi for 2 years. Nodules have disappeared. PSA undetectable. Some side effects, hot flashes, some dizziness, and joint pain. Not sure if just age, 80, or the drug. Rate a 9."

• jbr...
• Taken for 1 to 6 months
• March 10, 2026

Enzalutamide for Prostate Cancer "Fatigued, restless legs, hot flashes, spacey feeling in my head. 160 mg daily (4 pills a day). Fatigue being the worst right now."

• Ano...
• Taken for 2 to 5 years
• April 1, 2026

Enzalutamide for Prostate Cancer "I have hot flashes and tiredness. It knocks my PSA down, so I am able to get off pills for a while. When PSA rises again, I get back on the pills."

• Ern...
• Taken for 1 to 6 months
• October 8, 2026

Enzalutamide for Prostate Cancer "Hot flashes and less appetite, and also headaches, blurry eyes and body pains, sleeplessness."