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Safyral and Depression: What Users Say

Depression: mentioned by 14 users (20.9%)

Based on user experiences from 67 Safyral reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

cramps 31.3%
mood swings 29.9%
acne 23.9%
depression 20.9%
bloating 19.4%
weight gain 19.4%
bleeding 16.4%
nausea 16.4%
sore breasts 16.4%
moody 11.9%

Reviews for Safyral

Commonly mentioned side effects
  • Mis...
  • December 4, 2013

For Birth Control "As far as birth control and periods went, this was fine. My periods were much less crampy and painful, my skin didn't change at all. However, it was like my personality completely flipped. I felt robbed of my sense of adventure, I had absolutely no interest in going and doing fun things with my family. I've never had depression, but I think this must be what it feels like. I stopped taking it and am almost back to my old self, even though I'm back to having terrible periods. I will take cramps over how I was acting any day of the week."

2 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • February 19, 2013

For Birth Control "I've been on Safyral for about 6 months now. When my doctor first put me on this pill, I really liked it. It was my first time going on birth control, so I was nervous about all the weight gain rumors. But it was fine, I didn't gain any weight. I actually lost weight, and my breasts got bigger. My skin cleared up, it has been a great contraceptive so far, but it made me so emotional. Maybe 2 or 3 months in, I just got so depressed. Randomly, I would just get so sad and not even know why. I cried all the time, I had a short fuse. The littlest things would just upset me, and I've never been like that, so I'm switching. Everyone is different, though, and besides the emotions, it was a great birth control."

7 / 10
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11 Report
  • Ang...
  • March 24, 2015

For Birth Control "I just finished a package of Safyral yesterday, and so far I've had no weight gain, my acne has cleared up some, and my period came when it was supposed to. However, I have had spotting all through the first month, which the doctor said was normal, so I have no complaints other than one really big one. While being on this pill, I have had serious depression. I'm always moody, crying, and sad. I am so sad that I have no appetite, no desire to go out, I'm never happy. In fact, I get raging angry sometimes, and I cannot control any of this. I am hoping that this side effect goes away soon."

5 / 10
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5 Report
  • jes...
  • Taken for less than 1 month
  • June 4, 2012

For Birth Control "I have been on this for a month and have had a horrible experience with my mood change. I have always been a happy person, and now for the last week, I am so depressed and I am constantly feeling a nervous feeling in my gut, like anxiety. I had a baby 2 months ago, and even through my pregnancy, I never felt any mood swings or depression. I talked to my doctor and have decided to stop this birth control. Hope it'll fix this sad feeling."

4 / 10
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7 Report
  • Anonymous
  • April 8, 2012

For Birth Control "I have been on this pill for a couple of months now. It's great with acne and no weight gain or anything, but I will say it's absolutely horrible with moods. I've had the worst mood swings. I'm depressed, and I literally cry over anything, and when I start, I can't stop!"

3 / 10
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5 Report

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  • Anonymous
  • Taken for 6 months to 1 year
  • October 22, 2012

For Birth Control "No breakthrough bleeding, felt the best that I ever had, lost weight, and felt like my old self again. So, I started this medicine in April 2012 and am currently on it, and it's October 2012. This will be my last pack. I have experienced nausea, bloating, mood swings, sadness, depression, fatigue, and just don't feel like myself anymore."

5 / 10
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7 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • October 22, 2012

For Birth Control "No breakthrough bleeding, felt the best that I ever had, lost weight, and felt like my old self again. So, I started this medicine in April 2012 and am currently on it, and it's October 2012. This will be my last pack. I have experienced nausea, bloating, mood swings, sadness, depression, fatigue, and just don't feel like myself anymore."

5 / 10
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  • Anonymous
  • September 28, 2011

"Took this for 4 months after having a baby. Having cravings for sugar and carbs. Severe breast tenderness and severe mood swings and depression. I have severe hot flashes and feel like a menopausal woman. They did all kinds of testing on me and said it must be this pill causing it. I'm going off it next week! It has completely changed my personality and made me into an angry hormonal woman with mood swings daily."

1 / 10
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3 Report
  • Kar...
  • July 28, 2013

For Birth Control "I had a pretty good experience with Safyral while I was on it. It helped regulate my cycle to be much more predictable and on time, and helped with my often severe leg cramps. I didn't experience any weight gain, and though I was sometimes moody, it wasn't anything outside of normal PMS. It did what it was supposed to do, I suppose. However, my problems were when I had to go off Safyral. My insurance stopped covering it, and at first, my OB/GYN didn't have any samples for me, so I had to stop taking it for a while. This is when I started to gain weight and had some crazy mood swings. I felt kind of depressed at times, cried often at work (which is unlike me), and just felt over-emotional."

7 / 10
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6 Report
  • Saf...
  • July 12, 2015

For Birth Control "So I've been on this birth control for about three months. In the beginning, I was hungry all the time, and it really upset my stomach. After about three weeks, that was gone and it was awesome. No babies. Easy periods, almost no cramps, it was too good to be true. Now here I am, three months into the pill, and I've hit a horrible depression. I've never been depressed. But every day I cry and get so sad I can't go out, and I don't want to eat or do anything. I've diminished. So I've decided to get off the pill immediately. I think I'll stick to the condoms. I would rather use condoms than be overwhelmingly sad all the time."

5 / 10
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  • Sha...
  • Taken for 2 to 5 years
  • April 26, 2015

For Birth Control "I was put on this birth control at the age of 14 due to severe ovarian cysts and breakthrough bleeding from other pills. It was absolutely wonderful the first two years. My skin glowed, I kept a great weight, my periods were always on time. However, all this soon went downhill around the third year. I started to have overwhelming feelings of depression wash over me multiple times during the day, I became sluggish, I didn't want to do things with friends or family, and my relationships suffered greatly overall. After stopping this pill, my mood swings diminished, and I feel like my old self again. Never going back to this pill again."

2 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • August 8, 2013

For Birth Control "I have been on this pill for two years. I switched to this from Ortho Tri-Cyclen because I was having breakthrough bleeding. One month into it, I was having terrible cystic acne, two months into it, I had a severe panic attack. Two years later, I am incredibly depressed and bloated before my period, along with crazy migraines for 3-4 days straight. I am unable to lose weight even with running 4 miles a day. I am switching to Lo Loestrin 24 Fe and will try a lower-dosed pill. I have also experienced terrible leg cramps and fatigue like never before."

2 / 10
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7 Report
  • Gir...
  • Taken for less than 1 month
  • March 17, 2017

For Birth Control "There are 4 pills left in the pack and all I can say is I am happy I have finally found the pill that works for me. I've tried a few different birth controls, but they all made me bleed for months on end. Had the Depo shot in my teens, came off of it, I had to go to the hospital. Tried it again at 25 years old: had 1 shot and bled for legit 5 months straight. I requested a low-dose pill. Took Lo Loestrin Fe for 1 month and that made me VERY on edge, angry, and depressed (I'm usually happy). Told my doctor I was 'done trying birth control!', but she persisted I try something else. She identified progesterone was too much for my system and thus came Safyral. I legit have zero side effects. Best decision ever. Going to get my new pack tonight!"

9 / 10
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  • kel...
  • May 29, 2013

For Birth Control "I've been taking this for two months. I've lost a much-needed 25 pounds, and my face is always clear. I have noticed a slight depression, though, but I feel it's tolerable and worth it."

9 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.