Bupropion / dextromethorphan for Major Depressive Disorder User Reviews (Page 5)

• Lil...
• Taken for 6 months to 1 year
• February 27, 2025

Bupropion / dextromethorphan "I have taken so many medications. Zoloft, Cymbalta, Effexor, etc. The list goes on. This is the best medication I have taken for my depression. I haven't felt this clear-headed on a medication before. I don't have my heavy lows, and I don't feel as though I'm heavily medicated. There wasn't a big process to go on it or come off of it. I recommend asking your doctor if you could be a good fit for this medication."

• CTC...
• Taken for less than 1 month
• April 24, 2023

Bupropion / dextromethorphan "For reference, I’ve been on Wellbutrin and Effexor for several years. I stopped the Wellbutrin when starting Auvelity and I just started weaning off the Effexor this weekend, so it’s too early to tell. However, since I do feel “lighter” already, I’m hopeful. The first couple of days at the full dose caused some dizziness and mania about two hours after taking, but both have decreased. I took the second dose a little later last night, and now I feel extreme fatigue, so I’m going to be more diligent about taking it earlier. The doctor said the side effects should go away soon, so I’ll update here. Again, I’m hopeful!"

• SJM...
• Taken for less than 1 month
• September 3, 2023

Bupropion / dextromethorphan "After 6 days, I feel less depressed & have more energy. I hope I can stay on Auvelity because I do have side effects of diarrhea with abdominal pain & an increase in tinnitus. I am taking 1 tablet a day."

• mom...
• Taken for less than 1 month
• January 22, 2023

Bupropion / dextromethorphan "I started Auvelity a few days ago. Some background information about me is that I’m on 450 mg of Wellbutrin and 40 mg of Lexapro. Unfortunately, the Wellbutrin or the Lexapro isn’t helping. I’ve been on Wellbutrin for 4 years and Lexapro for 3 years. My question is, have any of you been on Wellbutrin and switched to Auvelity? Doc switched me to one Wellbutrin per day, along with two Auvelity per day. If any of you have had the same experience with this same combination, I’d love to hear about it. I’m curious since Auvelity and Wellbutrin have bupropion in it. Thanks!"

• Kat...
• Taken for less than 1 month
• August 3, 2024

Bupropion / dextromethorphan "It has really helped with my depression, and I have been taking it for almost a week, so it’s fast acting. However, the side effects are making me want to stop taking it. I have chest pain, jaw pain, dizziness, horrible headache, excess sweating, vision changes, shortness of breath, and I almost pass out every time I stand up. I’ve continued taking it, though, in hopes that the side effects will subside because it has drastically improved my mental health, and I no longer have suicidal ideation. I love everything about it aside from the side effects."

• Sly...
• Taken for 1 to 6 months
• February 11, 2025

Bupropion / dextromethorphan "I felt better within days, and all side effects went away after a few weeks. I only take one pill a day, and it had put my depression into remission. No other drugs have ever worked for me, so I’m glad this new drug is available. I’ve been on it for six months."

• Ric...
• Taken for less than 1 month
• January 8, 2024

Bupropion / dextromethorphan "Started taking this medicine 6 days ago. It started making a difference today because I usually wake up around 3:30 ruminating and very depressed. This morning was much better. I didn't have the negative thoughts as bad and could let go of the rumination. However, after my second dose today, I'm super dizzy and irritable, so I'm hoping that goes away. I had a great day today, and I think it may be working, just not sure if the dizziness is from this medicine or the discontinuation of my Lexapro."

• cos...
• Taken for less than 1 month
• May 9, 2025

Bupropion / dextromethorphan "Shame on the drug manufacturer for charging $1,100 a fill for a two-combo drug of a pennies-on-the-dollar cough syrup ingredient teenagers get high on and has been around for 70 years, and a subtherapeutic dose of relatively cheap Wellbutrin, which has been around as of 2025 for its 40th FDA approval anniversary, and calling this combo a miracle new breakthrough. Shame on them. This shouldn't cost more than $50 if that, considering a GoodRx and Google search revealed a 30-day supply of 150 mg bupropion, which is a slightly higher dose than in Auvelity, the cheapest being $6.75, and an over-the-counter pack of cough syrup with dextromethorphan is $10. Wellbutrin is a stimulant, and the cough syrup is a euphoria-inducing agent. Neither are new breakthroughs worthy of an $1,100 a month price tag just because they're in one pill."

• hat...
• Taken for 6 months to 1 year
• March 13, 2024

Bupropion / dextromethorphan "I was on one Auvelity a day (45mg) even though the doctor had prescribed two a day for me. About 8 months after taking one a day, I felt my depression getting worse, so I told my doctor I would take two, his original prescription dosage. Two and a half to three weeks later, I have been experiencing much increased anxiety, feelings of discomfort and restlessness/nervousness, extreme agitation and fear. I did not know what was wrong with me until I decided to look up Auvelity side effects, which is why I will be going back to one tomorrow and calling my doctor. Another disappointment from the medical community that causes more problems."

• Bob...
• Taken for less than 1 month
• February 10, 2023

Bupropion / dextromethorphan "After the fourth day, I developed a violent cough. My doctor instructed me to stop taking the medication, but the frequent dry cough persisted for 2 months. I was previously prescribed Wellbutrin 20 years ago, which at that time was the best drug for me and lasted for 13 years before it stopped working."

• Anonymous
• Taken for 1 to 6 months
• August 1, 2024

Bupropion / dextromethorphan "I took this medication for 2 months. It did seem to improve my depressive symptoms within the first 72 hours of starting! However, I noticed that my feet were swelling. It got to the point where my left foot and ankle were constantly swollen. I didn't think it had anything to do with this medication, so I continued to take this while I worked with my primary care to figure out what was causing the edema. There were no answers, so I decided to stop Auvelity, and within 48 hours the swelling was gone. I have since stopped taking this medication due to my personal reaction."

• Ami...
• Taken for 1 to 6 months
• July 10, 2024

Bupropion / dextromethorphan "This tablet is used for adult major depression only, and do not drink coffee. Also, avoid tobacco products because it caused me movement problems after having coffee or tobacco products. It treats only depression. I have taken it twice daily, with fixed dosages that cannot be increased, otherwise, it will cause unwanted side effects like hallucinations, seizures, movement problems, etc. Overall, it is very safe and considered a miracle drug for some adult people."

• AnL...
• Taken for 1 to 6 months
• May 23, 2024

Bupropion / dextromethorphan "I started taking Auvelity as a supplement to my antidepressant as I became resistant to treatment. At first, I took one a day. I didn’t see much difference. So, my doc switched to 2 a day. I think it helped. But I started having a very dry mouth. It is affecting me, and I am not sure what to do about that."

• Ano...
• Taken for 6 months to 1 year
• January 21, 2025

Bupropion / dextromethorphan "I’ve been on Auvelity twice a day for about 6 months now, and although it has helped me tremendously, I started having an abnormal amount of vaginal discharge that started a couple of weeks after taking it and hasn’t stopped. I’ve been checked for everything and ruled everything else out, and even going down to 1 pill a day has only decreased the discharge by only a small amount. Is anyone else having this issue? I wouldn’t mind if it were normal discharge, but it’s slightly tinted (as is the medication), so it makes me very self-conscious."

• hos...
• Taken for less than 1 month
• June 18, 2023

"First of all, I didn't take the brand name, which costs over $1,000 a month. Most people are not aware that dextromethorphan is an over-the-counter cough suppressant. There is no need to pay the exorbitant price that the pharmaceutical company has set for this drug combination. You just need a prescription for generic bupropion and purchase a sustained-release dextromethorphan over the counter. This is what I did, and I felt a difference in my mood on day 2. I am a hospital pharmacist who has tried every antidepressant on the market. I am now treatment-resistant and decided to add dextromethorphan to my current antidepressant. I am pleased to report that I have had a positive response. Please don't pay the exorbitant price for the name brand. I am giving this drug combo an 8 out of 10 since I have only been on it for a few days. I will update later."

• BmA...
• Taken for 6 months to 1 year
• September 10, 2024

Bupropion / dextromethorphan "It does really help for MDD, but I don't think you can take it for more than one year because it increases dopamine levels over time, and it will cause you some unwanted side effects like weakness, seizures, OCD, etc. So now I am planning to stop completely because after stopping, I feel very well."

• hai...
• Taken for less than 1 month
• August 13, 2025

Bupropion / dextromethorphan "I’ve tried a number of medications for my anxiety and depression over the years. Prozac was the only one that truly helped, though after about 5 years the benefits started to subside. Over the last few months, I’ve tried a few other medicines. I tried Auvelity hoping it might improve mood and motivation, and I was hopeful due to positive reviews and the slight feelings of improvement I noticed. In the first week, however, I experienced very vivid dreams, flu-like symptoms including nausea, faintness, and overheating, as well as sleep disruption. My body felt extremely hyper-aware, as if I could feel every heartbeat and even subtle eye movements, and I never got to the twice-a-day dosing (only took 1 per day). After several weeks, I noticed no meaningful improvement in mood, energy, or motivation. I think those with sensitive nervous systems or heightened sensitivity to medications may find the side effects difficult to tolerate, and for me, they outweighed any benefits."

• beh...
• December 5, 2022

Bupropion / dextromethorphan "This drug is really helping me out and acted in less than 2 weeks."

• Dep...
• Taken for less than 1 month
• November 19, 2022

Bupropion / dextromethorphan "Really great experience, feel a lot better. Have only been taking it for a few weeks, though, so we’ll see."

• Mar...
• Taken for less than 1 month
• July 14, 2023

Bupropion / dextromethorphan "I've been on this drug for 2 weeks and every day is better. I actually get out of bed. I've tried several other rx and over time they go flat. I look forward to my continued improvement."

• jak...
• Taken for less than 1 month
• May 24, 2023

Bupropion / dextromethorphan "From the first day, it worked well. It raised my spirits a lot and gave me energy, calmness, and the desire to do things."

• Sun...
• Taken for less than 1 month
• December 24, 2022

Bupropion / dextromethorphan "I haven't had any side effects. I'm on day 3 and taking it with Lexapro and Hydroxyzine. So far, so good."

• Mig...
• Taken for 1 to 6 months
• April 21, 2023

Bupropion / dextromethorphan "Worked very well on me from the very first week. Works similarly to ketamine, without the hassle of taking a scheduled drug."

• jan...
• Taken for 6 months to 1 year
• June 4, 2023

Bupropion / dextromethorphan "Helped with energy, anxiety, and having an interest in life again."

• gar...
• Taken for 1 to 6 months
• August 29, 2023

Bupropion / dextromethorphan "Never felt better, cannot afford. Cost first time $95.00, second $95, third $114, and then off the wall $270.00! I can't afford to take it but I can't do without. Fixed income, 77 years old."