Auvelity for Major Depressive Disorder User Reviews (Page 4)

• Dre...
• Taken for 1 to 6 months
• August 30, 2023

"I’ve been on Auvelity for almost 2 months after taking Wellbutrin for 10+ years. Auvelity is vastly superior to Wellbutrin in my experience. Within a few days, I felt my heaviness lifting and a peaceful lightness emerging. I find joy and happiness in small things again and enjoy spending time with my kids, including one with serious special needs. Also, with the chaos that can occur with 4 kids, including 1 with severe autism, my level of agitation is greatly reduced with minimal yelling, when they inevitably misbehave. I’m much more effective in staying calm and productively parenting. I feel a deeper connection with myself, others, and the world. My former intense anxiety is greatly reduced, I’m kinder and more compassionate. I’ve gone from about 8 drinks per week to no need to drink or self-medicate in 60 days. Auvelity is beyond an antidepressant, it’s a physically and spiritually uplifting wonder drug."

• Jac...
• Taken for less than 1 month
• March 9, 2023

"I have been taking Auvelity for about a week. While the medication is working and my mood is better, the sexual side effects are not. I cannot find anywhere if the side effects diminish over time. The mood is great, energy is back, motivation, and everything. The nausea is okay."

• Mid...
• Taken for 1 to 6 months
• February 3, 2025

"It has brought back my old younger self. Back to being a spitfire, which is a good and bad thing, but nonetheless, I'd say it helps. Lots of energy back. It can be extremely expensive without insurance, but the website for Auvelity had the ability to help with costs."

• C A...
• Taken for 1 to 6 months
• August 16, 2024

"I was about to give up. 30 years trying to find treatment that worked for my MDD. My psychiatrist had gotten some samples of Auvelity that morning, and he recommended I try it. Skeptical that it would work, and since I didn't have to wean myself off the antidepressant I was on, I took one on the way home. About 10 minutes later, it was like a switch was flicked. The heaviness I'd felt disappeared, everything was brighter, and I felt better than I had in 25 years. I was amazed at how fast it worked for me. 3 months later, and it's still working. I'm a new person, enjoying my life instead of sitting in the darkness of my room. The only side effect I have is sudden muscle movement, but it is slight and nonobtrusive. No facial tics. My doc said it was not usual to have such instant results, but many report that they feel better in just days after starting Auvelity. I'm still pinching myself, so happy now with my new life!"

• Dai...
• April 16, 2023

"I have been on antidepressants all my life. I have taken all medications available in the market. I started Auvelity 3 days ago. I was told to stop my two other antidepressants the day I started Auvelity. I have an enormous feeling of anxiety and despair. I am extremely depressed, unmotivated, flat affect. I don't want to do anything except hide under the covers. The only problem is that my body won't allow me to relax because I have anxiety and restlessness. It's Sunday. I will stick with the medication, but I think I feel worse."

• Hoo...
• Taken for less than 1 month
• August 25, 2023

"I started taking Auvelity on Mon, 8/14/23. I was prescribed 1 tablet every 12 hours. I also take 200mg of sertraline daily and 10mg of buspirone daily. I felt my depression lift within 24 hours of starting Auvelity. This medication was amazing and I had a new outlook on life again, this time without the damaging side effects ECT. However, by Friday evening, 8/18, I was experiencing a severe headache, dizziness, nausea, and a 'high' feeling like I was on illegal drugs. On Saturday, I started feeling jerky movements in my muscles, and I was getting double vision. On Sunday, I was sent to the ER via ambulance. I had Serotonin Syndrome. This was NOT THE MEDICATION'S FAULT. My prescriber had not decreased my other SSRIs. On Monday, 8/21, buspirone was discontinued, and sertraline decreased to 50mg at night. Auvelity was changed to once daily. I know it's going to take a while for my body to adjust, but today is Friday, 8/25, and I'm feeling really 'loopy' and out of it."

• 6...
• Taken for 6 months to 1 year
• September 4, 2023

"Six months on this medication. I have suffered from MDD for decades and meds have pooped out, especially when there is a trigger in my life that adds distress. I am still doing well. It took 2 months for it to really start working, but after 6 weeks I really enjoyed conversations again. Those who have diarrhea, I did too and it gets better. Discount card if you have insurance is a blessing. It being a brand new type of medication that targets glutamate should bring hope to many."

• MDD...
• Taken for 1 to 6 months
• March 8, 2025

"I took Auvelity for about 3 months. I suffer from MDD, SAD, and GAD. I also work in health care and am on my feet all day. I felt a difference in my energy after the first few doses of this med. It helped me tremendously that first month when I was suffering with depression. After the next few months, I had to stop taking this med due to my severe GAD and insomnia. I think this med is excellent and effective with individuals with treatment-resistant depression, who suffer more from depression vs. anxiety. Some of us, like me :), just have too much anxiety to tolerate it. I am not saying this med causes anxiety, I cannot give it a bad rep because it truly did help my seasonal depression/MDD episodes, and I am thankful that I was able to take this medication! I just need something less stimulating due to my anxiety and insomnia. If you are suffering deeply with MDD and cannot get relief from a regular SSRI, I recommend it. I hope it helps you like it did for me when I needed it :)"

• Pai...
• Taken for less than 1 month
• August 4, 2024

"Currently cross-tapering off Zoloft and starting Auvelity. I'm about 5 days in and WOW!!!! The difference I feel so soon, and I'm only taking half a dose?!!! I am amazed. I am 22 and have been diagnosed with MDD, OCD, panic disorder, and anxiety. I am finally enjoying life and starting to wonder if this is what “normal” feels like! I'm excited to see the full effect after completely stopping Zoloft and taking the full dose of Auvelity."

• XYZ...
• Taken for 6 months to 1 year
• March 30, 2025

"I have been suffering major depression, anxiety since college graduation. That was 50 years ago. Since then, I have tried EVERY SRI, SNRI, and other classic antidepressants with ZERO positive effects. Waiting the 10-14 days to feel a therapeutic effect was always and every time completely disappointing. FINALLY, my doctor suggested Auvelity. Within only a few days, I noticed I was feeling better, it was shocking! What's VERY good? Auvelity is dextromethorphan and Wellbutrin (oddly, Wellbutrin never worked for me and made me feel lousy). I describe Auvelity's fast effect as like that of a shot of whiskey. Since every other antidepressant took weeks to not work for me, I was shocked by the almost instant change in my mood and disposition!! The stuff worked for me! Since the main component is dextromethorphan (same as OTC cough syrup), I'm not afraid of it."

• lit...
• Taken for 1 to 6 months
• September 1, 2023

"I've been taking this medication for six weeks. It is a life changer. If you also take ketamine infusions, 100% will change your life. I started experiencing some side effects like sleepiness probably after 3-3.5 weeks from the start. I am okay with this side effect. I didn't feel that good since 2005. Unfortunately, my insurance doesn't want to cover it anymore. Not sure what I would do without it. Tried many different prescriptions. ketamine infusions help, but they're crazy pricey, and you need to do it every four weeks. This medication is a game changer."

• Ran...
• Taken for less than 1 month
• March 7, 2024

"Auvelity is a miracle drug for me. I have experienced no side effects whatsoever. I may have negative thoughts in between taking this medication twice a day, but they disappear when I take the second tablet."

• Meg...
• Taken for less than 1 month
• April 5, 2023

"My psychiatrist said a relatively new medication is helping patients like me. I've tried many antidepressants over 12 long, frustrating years and never saw results that were anything better than slight improvement of some symptoms. Then even the tiny improvements would disappear after a few months. From what I've read so far about Auvelity, my current symptoms and psychiatric history are in line with the kind of patient this medication is designed to help. That being the case, I am writing this review the day before I begin taking Auvelity and want to update my experience in real time. In 12 years of seeking relief from overwhelming depression, this is the first I've ever heard of a depression medication that takes fewer than 8 weeks to show any results. I'm encouraged by the clinical results I've looked into. I'm giving a 10/10 rating because it won't allow me to not choose a number, and I don't want to drag the average down if this ends up being amazing. (If not, I will say so!)"

• Rob...
• Taken for 1 to 6 months
• May 18, 2024

"My experience has been a positive one. I have been taking it for a few months now and after trying everything else, Auvelity plus Zoloft works. I'm just curious how everyone is paying for this expensive lifesaver."

• Lil...
• Taken for 6 months to 1 year
• February 27, 2025

"I have taken so many medications. Zoloft, Cymbalta, Effexor, etc. The list goes on. This is the best medication I have taken for my depression. I haven't felt this clear-headed on a medication before. I don't have my heavy lows, and I don't feel as though I'm heavily medicated. There wasn't a big process to go on it or come off of it. I recommend asking your doctor if you could be a good fit for this medication."

• Chr...
• Taken for less than 1 month
• September 23, 2023

"I have been on a variety of antidepressants for the past 15 years. I started Effexor about 6 months ago, and it was life-changing, but I still had depression and my anxiety was paralyzing. My psychiatrist put me on Klonopin for anxiety and Auvelity for depression. I was very hopeful this would be the combination that would allow me to function. The first week, I felt amazing despite having intense nausea and generally feeling kinda loopy like being on a pain pill. By week 2, those side effects went away. Now, I can’t wake up and can’t stay awake during the day. At first, it was just general tiredness, but now I fall asleep throughout the day, including while driving, regardless of how much caffeine I have had to help me stay awake. Although my depression has decreased, I go through intense and unexpected mood swings. I can be extremely happy and excited about an upcoming event and then randomly fall into a deep depression while on the way there. After a bit, I’m fine again."

• Eri...
• Taken for 6 months to 1 year
• September 12, 2023

"My experience with Auvelity has been positive. I started feeling better after 2 days on Auvelity. I was depressed for 4 months previously. I felt better for almost 3 months when I relapsed and was depressed for over 2 months while on Auvelity. Although it didn't put me into remission, I believe it shortened the cycle and I felt better when coming out of a depression. I definitely want to continue taking this cutting-edge medicine. I think they are onto something, targeting the NMDA receptors, since all other SSRI drugs haven't worked long-term for me. I've had no side effects while on this drug."

• One...
• Taken for less than 1 month
• November 11, 2024

"Just started taking the drug. You can feel the effects of dextromethorphan from the get-go. I was already on Wellbutrin, so I had to step down on my dosage to compensate. I've got a mild headache, and sex is still good. Make sure you get the savings card. Will knock the price down significantly."

• smb...
• Taken for 1 to 6 months
• September 29, 2023

"I suffer from a few mental health diagnoses: bipolar I, BPD, PTSD, agoraphobia, ADHD. I also have sleeping issues. I've been on nearly every medication available. I really wanted to try it, and my doctor was on board. He got Medicaid to approve it within a couple of hours. It works!! I actually feel happy sometimes and laugh more. I feel more alive. It's weird, and it's great. I don't get mad all the time. I feel different. I still feel depression. It's just not so heavy constantly. It didn't take long to feel the effects. I can actually think. Yes, it has side effects, they all do, lol. It makes me tired, so I do take a tablet at night. It does cause diarrhea. I take the 2nd in the morning with my Vyvanse. My medications are this: Lamictal (mood stabilizer, nothing else works), Topamax, Adderall, Vyvanse, Clonidine, Prozac. Most of us have been on so many meds we've lost count. Not very often do new meds come out. So far, I'm so thankful I asked my doc."

• Mar...
• Taken for 1 to 6 months
• August 8, 2024

"Improvement in that depression doesn't seem as deep or last as long. Only side effect that interferes with my day is sometimes I am very dizzy and definitely would not drive. I take the regular dose of 45/105 mg twice a day. I do take other meds that might increase the dizziness - my doctor knows all of my meds. I have been taking it for 4 weeks. Simple to take."

• Lif...
• Taken for 1 to 6 months
• April 6, 2024

"I have resistant depression and anxiety. After failing many other medications for depression, Auvelity has made me feel like a different person. I still need a different medication for anxiety. However, this medication is easy to take and has made such a positive impact on my life!"

• Cal...
• February 6, 2023

"I just started taking this medication a few days ago and woke up every morning with severe anxiety, and my blood pressure skyrocketed. If you have been diagnosed with hypertension, I wouldn’t recommend you take this. Wellbutrin alone had worked for me in the past as far as my energy levels and depression but gave me bad anxiety and made me sweat more than usual, which increased my body odor, so I stopped taking it. The only reason I started Auvelity was to help with my fatigue, which seemed to help in the past, but I can’t deal with the anxiety it gives me in the mornings. Will have to stop. One of the major benefits is my sexual desire has improved. My doctor added this medication along with Viibryd, which I was already on, which has sexual dysfunction. Altogether, I would give it a 6 out of 10. Would recommend it if you don’t have hypertension or anxiety."

• SJM...
• Taken for less than 1 month
• September 3, 2023

"After 6 days, I feel less depressed & have more energy. I hope I can stay on Auvelity because I do have side effects of diarrhea with abdominal pain & an increase in tinnitus. I am taking 1 tablet a day."

• CTC...
• Taken for less than 1 month
• April 24, 2023

"For reference, I’ve been on Wellbutrin and Effexor for several years. I stopped the Wellbutrin when starting Auvelity and I just started weaning off the Effexor this weekend, so it’s too early to tell. However, since I do feel “lighter” already, I’m hopeful. The first couple of days at the full dose caused some dizziness and mania about two hours after taking, but both have decreased. I took the second dose a little later last night, and now I feel extreme fatigue, so I’m going to be more diligent about taking it earlier. The doctor said the side effects should go away soon, so I’ll update here. Again, I’m hopeful!"

• mom...
• Taken for less than 1 month
• January 22, 2023

"I started Auvelity a few days ago. Some background information about me is that I’m on 450 mg of Wellbutrin and 40 mg of Lexapro. Unfortunately, the Wellbutrin or the Lexapro isn’t helping. I’ve been on Wellbutrin for 4 years and Lexapro for 3 years. My question is, have any of you been on Wellbutrin and switched to Auvelity? Doc switched me to one Wellbutrin per day, along with two Auvelity per day. If any of you have had the same experience with this same combination, I’d love to hear about it. I’m curious since Auvelity and Wellbutrin have bupropion in it. Thanks!"