Auvelity for Major Depressive Disorder User Reviews (Page 3)

• Lau...
• Taken for 1 to 6 months
• January 22, 2023

"I suffer from medicine-resistant depression and PTSD and have been taking Auvelity in addition to other antidepressants for about 3-4 months. I initially felt better for the first month, but then I regressed again. It was frustrating as I had just refilled Auvelity with a $100.00 copay. I believe that this medication could work for people without resistance, it just didn't work for me."

• A P...
• Taken for 1 to 6 months
• March 10, 2024

"I have severe, treatment-resistant depression. Been through four rounds of TMS and 22 medications. Auvelity has been unlike any mental health medication I've taken. The first few days, I felt outside myself, cloudy. When I went up to twice daily, it got to a point where I didn't feel safe driving. I stopped, restarted, went up to two slowly. I started with one dose late in the evening and gradually took it earlier. I then added the second dose before bed. I take it at 10 AM and 10 PM. I don't take it unless I've eaten something. Depression has improved a lot. So has my anxiety and paranoia. No more weird 'high' feelings, but it does make me drowsy. I'm one to struggle to sleep. Not anymore. I close my eyes and I'm out. Sometimes for 10 hours. After the first dose, sometimes I need an energy drink to stay awake. I can't brew the coffee strong enough. But I'm not suicidal. The oppressive, depressed 'doom' feeling is mostly gone. Not perfect, but the best so far."

• its...
• Taken for less than 1 month
• May 3, 2023

"I’ve recently added Auvelity to my repertoire of meds. Sertraline has been very effective for my anxiety, but I’ve still been struggling with depression. I’m about three weeks in, and I can definitely say I’ve noticed some improvements in my depression. I’d say it took close to three weeks before I noticed a response and not the one week it says. Side effects have been minimal, and I don’t notice any currently. So far, I’m happy, and I feel my depression lifting. Hoping this continues to work. Was on Wellbutrin for over a year and had no results with that. And tried a series of antidepressants, mood stabilizers, and antipsychotics."

• Lis...
• Taken for less than 1 month
• July 25, 2024

"My adult son had tried numerous prescriptions for help with depression, anxiety, and OCD. Auvelity has quieted his OCD (it's still there, but it's not as strong) and has immensely helped his depression. He has started appreciating music and art again, noticing things of beauty. He is hopeful for his future. He usually only takes one tablet per day in the morning."

• Lex...
• Taken for less than 1 month
• January 9, 2023

"I have had some success with Wellbutrin (Bupropion), but after a number of years, I seemed to have developed a tolerance. An increase in dosage caused me to have anxiety. I was hopeful Auvelity would help as it has similar properties. Sadly, the smallest dose created overwhelming anxiety that felt like I had taken a high dose of Wellbutrin. Although one should not expect half a sustained release, I was hoping it would reduce the anxiety. Auvelity, I felt, gave me more energy and even curbed hunger, which was a positive. Though, sadly, I still had severe anxiety, was jittery, and my heart was pounding. I couldn’t continue and went back to regular bupropion while searching for something else."

• Jan...
• Taken for 1 to 6 months
• September 6, 2023

"I've tried so many different antidepressants. This one has made my mood lighter. I feel not so sad. Less crying spells. More motivation to feel like going out and doing something. Not so much hopelessness. More humor. More feeling like being social. (Forgot to say I'm on my second month of this med.) The downside is minimal. When I do yard work or housework - I sweat way more than I used to. Sometimes a little clumsy. Slightly confused at times. A little more forgetful. A little more hungry, but no major weight gain. For me, this med has been a lifesaver. I have enjoyment where before I had very little. I've had some sexual side effects which I don't like. All in all - much improved. Much better. Hope this helps!"

• Boo...
• Taken for 1 to 6 months
• February 9, 2024

"Complete life-changer. After 40 years of trying multiple treatments, including ECT, this med works wonderfully. By virtually eliminating my depression (rumination, negative self-talk, hopelessness), the anxiety also disappeared. After decades of ingesting all sorts of chemical cocktails to treat depression, I now take only Auvelity, amlodipine, and vitamin D3, and honestly, have never felt better. Only ECT has worked this well for me. My Sjogren's symptoms are not as aggravating, and life itself is much brighter. I felt Auvelity working within a week and have been taking it twice a day for 4 months now. The only “side effect” has been that I need to take the second dose at least 8 hours before bed or I can get jittery when unwinding for the night."

• Jud...
• Taken for less than 1 month
• November 11, 2024

"I developed situational depression after we tragically lost our only daughter. Almost 4 years later, on Viibryd and Buspirone with minimal results, my psychiatrist put me on Auvelity. I am having the Viibryd titrated off. I am on day 3 and already feel better. How can this be? While we will always miss our daughter, it is sadness, not depression nor anxiety. I am feeling more like myself... my husband has commented thusly also. I hope this continues! I was apprehensive to start a new drug, but no side effects for me. Bless the makers of this med! I take 2 pills a day, spaced at least 8 hours apart."

• Jas...
• Taken for 1 to 6 months
• April 14, 2025

"I’m 44, began antidepressants at age 16. You name it, and I’ve tried it: SSRIs and SNRIs. I want to mention that I was already on Wellbutrin with little, but some success. When my doctor changed it to Auvelity, I noticed a difference the next day. Every day, my depression and mood improved. I’ve been on it for about 6 months now, and I can’t rave about it enough. If you have depression, I highly recommend you try it out. The way my doctor described it to me was while our bodies metabolize the bupropion, it gives the dextromethorphan a chance to work in the glutamate part of the brain, the same area ketamine works on. He said that’s why this medication works so well."

• sky...
• Taken for less than 1 month
• April 10, 2023

"I had just started taking this medication as I am diagnosed with Major Depressive Disorder, bipolar 2, and Generalized Anxiety Disorder. I was previously prescribed fluoxetine (Prozac) for depression. After about 2 months of being on it, I started to wonder if it was even doing anything. I brought it up with my HCP, and she recommended that I should try Auvelity. I had no issue with trying a new medication, especially because after reading the reviews, people said that they almost saw a positive instantaneous reaction. The first day I had taken it, I felt normal until around mid-day, and that is when I had one of the most intense and genuinely terrifying panic attacks I've ever experienced. I could not breathe or even speak, and it felt like my heart was beating out of my chest. Luckily, this only lasted for about 30 minutes until I had calmed down. The second day was even worse. I was enduring intense and extreme, almost debilitating paranoia."

• Mic...
• Taken for less than 1 month
• January 3, 2023

"I am starting my third week. I had nausea and headache up until today. Hopefully, they won't come back. I can't shake the suicidal thoughts, so not sure how the med is working. Hopefully, the thoughts will subside with time."

• Cra...
• Taken for 1 to 6 months
• December 5, 2024

"Really the first anti I've been on that made me feel like it was working. The first three weeks I had a cough med high that was pleasant. I've been on Auvelity for 6 months and had some strange side effects. I will gladly take losing my sex drive over losing myself in a dark pit. I can't say I'm doing a lot better, but I'm actually working with it for a change. I've been on them all, placebo effects almost always, but this hasn't diminished. Every antidepressant or antipsychotic did the same thing… start off great, then a few months later I was more aware of my depression and completely lethargic. I know this isn't listed on what Auvelity treats, but I suffered headaches almost daily and migraines 6-10 per month, but they have much improved. The daily headaches 90% improved. Migraines 75% maybe more. That alone is happiness."

• Rob...
• Taken for 1 to 6 months
• May 9, 2023

"At first, I thought I had found a winner. For the first few days, I was getting out for daily walks, more motivated with work, laughing more, and drinking a lot less - and no side effects! But then the benefits gradually disappeared, replaced by crippling insomnia and anxiety about a week after going up to two doses a day. I didn't sleep for four days straight; I was falling down walking to the bathroom and had double vision. It was really scary. I had to ask for a short course of Ativan or else end up in the ER. The insomnia resolved by dropping back to one dose, then the anxiety resolved immediately after discontinuation. Please be advised that there is no safe way to taper down from the starter dose (it's timed release), and most compounding pharmacies don't take insurance. So I got off cold turkey. I had only been on it a month, but after three days, I got brain zaps (manageable) for a couple of days, and anxiety and disorientation for several that have only just resolved. Good luck."

• Cha...
• Taken for 1 to 6 months
• February 17, 2024

"I have tried almost every antidepressant there is to no avail. I was scouring the internet because I knew there had to be something different. At my next psychiatry appointment, I asked about Auvelity because I had read how well it worked and my doc was fully on board. When I first began taking it, it honestly made me feel weird, but I didn’t want to stop. So I asked my doctor about taking it at night, and she said yes, that’s perfectly fine, and I went down to 1 pill. This small change has helped tremendously, and I no longer have side effects, but I still feel like I need something more, so I am going to try taking the second pill in the morning, and I really feel like that will get me over the proverbial hump. I also take Vyvanse for ADHD, Lexapro (which I plan on getting off of), and Trazodone for sleep. I think I have found what works for me finally."

• Spk...
• Taken for 1 to 2 years
• August 22, 2024

"It helped me feel immensely better from chronic, treatment-resistant major depressive disorder. It helped me feel more normal than anything else I had tried in the last 20 years. I could not take it twice a day, or I wouldn’t be able to sleep at night. So I only took it once in the morning, and it still seemed to make quite a difference. It causes mild diarrhea daily, but not enough that it’s terrible."

• Auv...
• Taken for 1 to 6 months
• April 24, 2024

"I was very depressed because most of my cats and kittens died from feline panleukopenia. This was in late October and early November. I was recovering from two surgeries in October, which made the depression worse. I started Auvelity in December. Two weeks later, I felt calmer with less anxiety. I wasn't crying every day over losing my cats. I felt a sense of being somewhat more in control of my emotions. I feel better in the morning and I seem to have more energy. Auvelity has been the most effective antidepressant for me. Carol in Idaho"

• Mud...
• Taken for less than 1 month
• March 24, 2023

"Switched two weeks ago from 450 mg Wellbutrin AM to Auvelity AM and pm. I also take Lamictal and Fetzima for depression, Vyvanse for focus, Klonopin pm for anxiety, and Ambien, gabapentin, baclofen, and Vyepti for migraine prevention, which have some interactions with my depression meds. My mood is definitely better, as is my motivation beyond basics like getting dressed, eating, etc. I’m starting to handle more complex things and tackle important projects that my guilt, shame, and fear made impossible. My ability to think clearly and focus fades when the Vyvanse ends around 2 pm. Still struggling with other depressive symptoms and having strange side effects: dizziness, eyesight problems, and lack of appetite. It’s like I move my head and my eyes are a second behind. Really tough. I get crazy sugar cravings every night. I’m hoping dizziness, eyesight, and cravings fade. Otherwise, I like it a lot. Hate taking two times a day, though. Insurance took two months despite my savings card!"

• Wow...
• Taken for 1 to 6 months
• April 19, 2025

"I've struggled with depression since I was 19—I'm now 32. After contracting COVID in late 2021, my depression became seemingly untreatable. I tried several different medications, but they were either ineffective or made things worse. I was on the verge of starting ketamine treatment when my doctor mentioned Auvelity as a possible alternative. Since I had previously been on Wellbutrin, we weren’t sure if insurance would cover it—but thankfully, it does, and I’m only paying $10 a month. I’ve been on Auvelity for just one month, and oh my goodness—it’s been a lifesaver. At first, I felt foggy, had memory issues, and experienced a strange dryness I can’t quite explain. But after about three weeks, the benefits kicked in. I finally feel like myself again—like I did before COVID. Hope is not lost after all!"

• Woo...
• Taken for 1 to 6 months
• June 23, 2023

"Unfortunately, it didn't work for my major depression. I was really hoping this would be the one. My depression is really hard to treat, so I don't know, it doesn't mean it won't work for someone else, though. No real side effects I noticed besides if you forget a dose. For me, it was mild withdrawal symptoms. Anyone who has discontinued a psych medication will know what I mean."

• Kay...
• Taken for less than 1 month
• May 19, 2023

"I was very hopeful Auvelity would work for me, but unfortunately, I experienced the very rare serious side effects. The first day I took it, I felt dizzy and drunk with a small increase of anxiety. The next day I took it, I felt the same experience with added paranoia. I was in the middle of a busy Costco, so it was not fun (thankfully I didn't drive myself there). It made me feel so intoxicated that I could barely form sentences. I thought my body would be getting used to it, so I took it on day 3 after work. Holy hell, it took me on a ride. I was dizzy, felt drunk/high, anxious, paranoid, and now delusional. I thought my bf was mad and breaking up with me, but later confirmed that it wasn't remotely true. It takes a few hours to wear off, and after, I have poor memory of things that happened during. I had real mental clarity the next day that I haven't felt in years, so it's a shame I had to stop taking it. It's 100% worth a try, but don't drive until you know how it affects you! Good luck!"

• Raf...
• Taken for less than 1 month
• November 20, 2023

"I was on Wellbutrin for years for mild depression and severe ADHD. It helped keep me motivated and more organized than usual. I started Auvelity a week ago and do think it is helping. I generally feel less negative and worried. Less rumination in my head. But physically, I have had side effects and don't think I can increase to the full dose. I feel a little dissociated 1-2 hours after taking it - light-headed, trouble concentrating, physically buzzy and loopy. Once that passes, I feel a slight nausea come and go throughout the day. I also yawn a lot. I'll give it a month at 1 tablet and see how it goes."

• Dre...
• Taken for 1 to 6 months
• August 30, 2023

"I’ve been on Auvelity for almost 2 months after taking Wellbutrin for 10+ years. Auvelity is vastly superior to Wellbutrin in my experience. Within a few days, I felt my heaviness lifting and a peaceful lightness emerging. I find joy and happiness in small things again and enjoy spending time with my kids, including one with serious special needs. Also, with the chaos that can occur with 4 kids, including 1 with severe autism, my level of agitation is greatly reduced with minimal yelling, when they inevitably misbehave. I’m much more effective in staying calm and productively parenting. I feel a deeper connection with myself, others, and the world. My former intense anxiety is greatly reduced, I’m kinder and more compassionate. I’ve gone from about 8 drinks per week to no need to drink or self-medicate in 60 days. Auvelity is beyond an antidepressant, it’s a physically and spiritually uplifting wonder drug."

• Jac...
• Taken for less than 1 month
• March 9, 2023

"I have been taking Auvelity for about a week. While the medication is working and my mood is better, the sexual side effects are not. I cannot find anywhere if the side effects diminish over time. The mood is great, energy is back, motivation, and everything. The nausea is okay."

• Sly...
• Taken for 1 to 6 months
• February 11, 2025

"I felt better within days, and all side effects went away after a few weeks. I only take one pill a day, and it had put my depression into remission. No other drugs have ever worked for me, so I’m glad this new drug is available. I’ve been on it for six months."

• MDD...
• Taken for 1 to 6 months
• March 8, 2025

"I took Auvelity for about 3 months. I suffer from MDD, SAD, and GAD. I also work in health care and am on my feet all day. I felt a difference in my energy after the first few doses of this med. It helped me tremendously that first month when I was suffering with depression. After the next few months, I had to stop taking this med due to my severe GAD and insomnia. I think this med is excellent and effective with individuals with treatment-resistant depression, who suffer more from depression vs. anxiety. Some of us, like me :), just have too much anxiety to tolerate it. I am not saying this med causes anxiety, I cannot give it a bad rep because it truly did help my seasonal depression/MDD episodes, and I am thankful that I was able to take this medication! I just need something less stimulating due to my anxiety and insomnia. If you are suffering deeply with MDD and cannot get relief from a regular SSRI, I recommend it. I hope it helps you like it did for me when I needed it :)"