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Benzoyl peroxide / clindamycin topical and Swelling: What Users Say

Brand names: Benzaclin, Duac, Onexton, Acanya, Neuac, Z-Clinz 10

Swelling: mentioned by 15 users (2.6%)

Based on user experiences from 576 Benzoyl peroxide / clindamycin topical reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dryness 24.0%
dry skin 15.1%
peeling 12.2%
burning 11.8%
itching 11.1%
redness 10.2%
acne 3.8%
pain 3.0%
stinging 3.0%
swelling 2.6%

Reviews for Benzoyl peroxide / clindamycin topical

Commonly mentioned side effects
  • Anonymous
  • Taken for 1 to 6 months
  • January 24, 2017

Benzoyl peroxide / clindamycin topical for Acne "I've been using this product for about 6 months now, and it is great. I noticed that it also prevents breakouts from happening, as well as getting rid of existing breakouts, and it also fades scars due to the bleaching effect. I would not recommend you use this around your eyes or on your eyelids, the product can make them puffy. Also, apply a very thin layer because this product is very drying! As an effect of drying out all the oils, causing clearer skin. Overall, this is a great product, and I would highly recommend it to anyone who has acne."

9 / 10
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14 Report
  • Jen...
  • August 19, 2016

Benzoyl peroxide / clindamycin topical for Acne "I went to my dermatologist after suffering throughout my teenage years with acne. They prescribed me Duac gel. The first few days of using it, my skin was fine, apart from a few red, patchy areas of skin. In my second week of using it, I was in constant pain. My face was inflamed, swollen, incredibly dry, and unbearably sore. I decided to stop using it and allowed my skin to recover from my traumatic ordeal, I had honestly never felt worse about myself. I then decided to give it another go, but this time using it for an hour a day, every other day. Once I felt my skin had acclimatized, I did an hour every day. Now I can apply it overnight without any redness or dryness. My skin has cleared up so much, but I recommend acclimatizing your skin."

9 / 10
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15 Report
  • Jen...
  • August 19, 2016

Benzoyl peroxide / clindamycin topical for Acne "I went to my dermatologist after suffering throughout my teenage years with acne. They prescribed me Duac gel. The first few days of using it, my skin was fine, apart from a few red, patchy areas of skin. In my second week of using it, I was in constant pain. My face was inflamed, swollen, incredibly dry, and unbearably sore. I decided to stop using it and allowed my skin to recover from my traumatic ordeal, I had honestly never felt worse about myself. I then decided to give it another go, but this time using it for an hour a day, every other day. Once I felt my skin had acclimatized, I did an hour every day. Now I can apply it overnight without any redness or dryness. My skin has cleared up so much, but I recommend acclimatizing your skin."

9 / 10
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15 Report
  • mar...
  • Taken for less than 1 month
  • December 23, 2013

Benzoyl peroxide / clindamycin topical for Acne "I applied Duac on my face as instructed, and after 2 days of using it, I noticed that my pimples started to disappear, but the problem is my whole face got swollen, itchy, and red. I can't even sleep and go to school for days. So what I did is visit my doctor again, and he told me that those were the side effects of the product and told me to stop using it. To relieve the stinging and redness, I used an ice pack on my face and put moisturizer non-stop. Luckily, after a few days the swelling and redness disappeared. Thank God my acne disappeared, and since then, whenever pimples appear on my face, I just applied the gel directly on the pimples."

6 / 10
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13 Report
  • Lil...
  • Taken for less than 1 month
  • September 26, 2018

Benzoyl peroxide / clindamycin topical for Acne "After using Duac with excellent results on my sebaceous hyperplasias and acne for two weeks, one morning I put the gel on my face and my skin became horrifically swollen, red, and painful. I also became nauseous. Even my neck, scalp, and lips were inflamed, and I did not apply Duac there. After removing the gel, I remained nauseous and somewhat inflamed the rest of the morning, but my skin eventually settled down, with residual redness around my eyelids, which lasted for days. Very disappointed that I had such a reaction after it was working so well, but I cannot risk ending up in the hospital, so I discontinued it and will speak to my dermatologist about alternatives."

4 / 10
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7 Report

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  • Lil...
  • Taken for less than 1 month
  • September 26, 2018

Benzoyl peroxide / clindamycin topical for Acne "After using Duac with excellent results on my sebaceous hyperplasias and acne for two weeks, one morning I put the gel on my face and my skin became horrifically swollen, red, and painful. I also became nauseous. Even my neck, scalp, and lips were inflamed, and I did not apply Duac there. After removing the gel, I remained nauseous and somewhat inflamed the rest of the morning, but my skin eventually settled down, with residual redness around my eyelids, which lasted for days. Very disappointed that I had such a reaction after it was working so well, but I cannot risk ending up in the hospital, so I discontinued it and will speak to my dermatologist about alternatives."

4 / 10
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7 Report
  • Bba...
  • Taken for less than 1 month
  • April 17, 2018

Benzoyl peroxide / clindamycin topical for Acne "Used this for two days only at night. It may have reacted with my usual night moisturizer, but my skin broke out into a red, burning rash. My skin is scaly and itchy. I stopped using this product and hope I am able to find something that won't cause a reaction. It is too bad because there have been some great reviews, although it doesn't work for my skin type at all. It has been over two straight days of burning, red, swollen, and irritated skin on my face. I didn't use a large amount either."

2 / 10
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  • Hap...
  • April 22, 2021

Benzoyl peroxide / clindamycin topical for Acne "I had rosacea and seborrheic dermatitis on my entire face. It was red and flaky with little bumps everywhere apart from under my eyes. I was prescribed Duac with doxycycline and steroid cream. The first couple of days the texture of my skin improved, and it was less angry. I felt Duac was slightly burning though, but I pushed on. After a week or so of use, this changed, and I started waking up with swelling around my eyes. I decided I had to stop use as my skin was also left so dry and stinging during the day that I couldn’t even stand water on it. Continued on for a bit with my other meds, and my face was completely clear for over 6 months. My issues returned recently, so I started Duac again with doxy and Celestone. I wash off Duac after an hour, then use Celestone. I have some redness and drying, but it’s bearable. Clearing up nicely so far, only mild swelling on day 2. Tip: 50+ sunscreen during the day."

8 / 10
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3 Report
  • Ros...
  • Taken for less than 1 month
  • August 13, 2016

Benzoyl peroxide / clindamycin topical for Acne "I went to the doctor's about my acne, and she prescribed me this gel. I used it on my face the first night I got it, and it was fine, I woke up with a few red patches, but overall thought it worked well. I applied it on the second night, and I woke up to severe redness and itchiness on my face, as well as big dry patches on my cheeks, chin, and forehead. Turns out I had an allergic reaction to this gel, which has left my sensitive skin unbearable to look at. It has caused my eyes to swell up, and itching still persists."

1 / 10
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10 Report
  • Anonymous
  • Taken for less than 1 month
  • July 28, 2012

Benzoyl peroxide / clindamycin topical for Acne "This cream worked really well and started clearing my face in a week or two. But now, anytime I go outside and have any sun contact, my face burns, gets blotchy, and looks swollen. I hate it, I have to stay inside all day if I apply it."

4 / 10
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  • Sad...
  • Taken for less than 1 month
  • March 18, 2018

For Acne "I never had a problem with acne. As a woman, I was diagnosed with PCOS (Polycystic Ovary Syndrome), which causes adult acne. I had it mildly, 2-3 pimples a month. My doctor suggested Clindamycin and Benzoyl Peroxide Gel (to be applied twice a day). I used it for only 3 days and had to stop. The first 2 days, my skin felt tight and slightly irritated. I thought it was a normal reaction after having read reviews. Day 3, I noticed that the 1 pimple I had was going away. I was happy. Day 4, I woke up and went to wash my face and apply the gel, and when I looked in the mirror, I was horrified. The left side of my face under my eye, by my nose, my cheek, and chin were swollen, hived up, red, and very irritated. I stopped using the medication. I took a Benadryl, thinking it might be an allergic reaction to the Clindamycin, but it did not help. It has been 4 days with this rash, and it is getting worse. I am going to the ER."

1 / 10
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  • Gir...
  • Taken for 1 to 6 months
  • April 8, 2018

For Acne "I suffered severe acne, but it was mostly on my forehead. My doctor prescribed me benzoyl peroxide, and I started using it every night, and by 3 weeks, all of my spots had cleared up. Even though there were still visible scars, the results were amazing. I continued using the prescription for 4 months or so, and no spots appeared. In the summer, I ran out of the medication, and my skin was getting slightly worse, so I asked to be prescribed more benzoyl peroxide, and I applied it on my face that night. The next morning, my face was completely swollen, I had an allergic reaction to it, which was weird because that had never happened before. I’m not sure if there was something wrong with the benzoyl peroxide or if it just didn’t work anymore. It’s been 6 months, and my acne hasn’t cleared up as my doctors keep prescribing me rubbish! I’m on erythromycin tablets, I’m literally praying it works."

8 / 10
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  • ann...
  • Taken for less than 1 month
  • April 24, 2018

Benzoyl peroxide / clindamycin topical for Acne "I'm 21 years old. I've pretty much hormonal acne on my whole face. My dermatologist recommended this gel, and I've been using it since. The last two weeks, and there's no significant difference. But my acne is becoming inflamed and leaving horrible scars. After reading reviews, I'm a bit hopeful that it will cure my acne."

2 / 10
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  • Wol...
  • December 23, 2013

For Acne "It did make some of my pimples smaller, however, my face is now red and itchy! My left cheek is swollen and has a red patch on it."

2 / 10
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6 Report
  • Anonymous
  • Taken for less than 1 month
  • August 12, 2017

For Acne "This gel was very effective. My face was swollen because of the acne, and I had bumps all over my face. Thanks to the gel, my face was back to normal."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.