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Benzoyl peroxide / clindamycin topical Pregnancy and Breastfeeding Warnings

Benzoyl peroxide / clindamycin topical is also known as: Acanya, Benzaclin, Duac, Neuac, Onexton, Z-Clinz 10, Z-Clinz 5

Medically reviewed on September 11, 2017

Benzoyl peroxide / clindamycin topical Pregnancy Warnings

Animal studies have not been reported. Developmental toxicity studies when clindamycin was given orally or subcutaneously failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy.

AU TGA pregnancy category A: Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

This drug should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.

AU TGA pregnancy category: A
US FDA pregnancy category: C

See references

Benzoyl peroxide / clindamycin topical Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Unknown
Excreted into animal milk: Data not available

Comments:
-Orally and parenterally administered clindamycin have appeared in breast milk.
-The infant's skin should not come into direct contact with the areas of skin that have been treated.
-Only water-miscible creams or gels should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.

See references

References for pregnancy information

  1. "Product Information. Acanya (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals, Costa Mesa, CA.
  2. "Product Information. Duac (benzoyl peroxide-clindamycin topical)." Stiefel Laboratories Inc, Coral Gables, FL.
  3. "Product Information. BenzaClin Topical Gel (benzoyl peroxide-clindamycin topical)" Aventis Pharmaceuticals, Swiftwater, PA.
  4. TGA. Therapeutic Goods Administration. Australian Drug Evaluation Committee "Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregancy. Available from: URL: http://www.tga.gov.au/docs/pdf/medpreg.pdf." ([1999]):
  5. "Product Information. Onexton (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals, Costa Mesa, CA.

References for breastfeeding information

  1. "Product Information. Duac (benzoyl peroxide-clindamycin topical)." Stiefel Laboratories Inc, Coral Gables, FL.
  2. "Product Information. Onexton (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals, Costa Mesa, CA.
  3. "Product Information. BenzaClin Topical Gel (benzoyl peroxide-clindamycin topical)" Aventis Pharmaceuticals, Swiftwater, PA.
  4. "Product Information. Acanya (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals, Costa Mesa, CA.
  5. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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