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User Reviews for Endep

Endep has an average rating of 6.6 out of 10 from a total of 43 ratings on Drugs.com. 56% of those users who reviewed Endep reported a positive effect, while 21% reported a negative effect.

Condition Avg. Rating Reviews Compare
Pain  
6.9
13 reviews 1123 medications
Fibromyalgia  
8.1
9 reviews 20 medications
Depression  
6.8
8 reviews 78 medications
Insomnia  
6.3
8 reviews 106 medications
Anxiety and Stress  
4.3
4 reviews 9 medications
Chronic Myofascial Pain  
1.0
1 reviews 42 medications
Summary of Endep reviews 6.6 43 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Endep

JJ · Taken for less than 1 month January 30, 2021

For Fibromyalgia: “Two days after taking Endep 10mg, 50% of my pain was gone. Lasted three days then the pain came back. Up the dose to 20mg and pain reduced again but legs feel twitchy and restless in the day. A weird feeling, usually happens at night. Will keep trying and see if it goes alway. Next step up to 30mg. So far it’s better than being in constant fibromyalgia pain 24/7. It did take 4-5 days to get use to sleep side effect. Within an hour of taking go straight to bed and try and sleep. Able to sleep with only waking once. Does make you tired in the morning but again it’s better than the pain. Worth a try. Good luck”

8 / 10
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Night Owl · Taken for less than 1 month October 1, 2020

For Pain: “Endep worked for pain 100% but put me in a mental ward Destroyed my life Get tested to see if you are, allergic to amitripyline first It was very dangerous for me I only had 13 tablets”

1 / 10
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JJ · Taken for 6 months to 1 year August 26, 2020

For Anxiety and Stress: “My doctor suggested I take Endep 25mg after being diagnosed with Crohn’s. I had been very sick for months and not coping very well. The first week of taking it I was rather spaced out but that was all. My day 7 my nausea was 80% gone, I was sleeping like a baby at night and I was dealing with the stress in my life a lot better. I have been on it for 7 months now and I don’t think I would have gotten through this year without it. The old me would have been having panic attacks and catastrophic thinking over the bush fires and Covid but thanks to Endep I have been able to stay calm and reasonable. I haven’t experienced any negative side effects at all. I guess if anything I can’t get up in the night to my kids bc I’m so deeply asleep but that ok because it just means dad has to get up. Haha”

9 / 10
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Frequently asked questions

Foges · Taken for less than 1 month March 19, 2013

For Pain: “10mg used to provide a pain free nights sleep. I have a pinched sciatic nerve. After cortizone injection under general anesthetic I experienced cramps that disturbed my sleep. This medicine is now giving me a good nights sleep and I wake refreshed in the morning.”

9 / 10
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Hayley October 5, 2019

For Pain: “I am 37 years old I started getting headaches at 13 from what I can remember I went on day to day year after year when I was 26 I was put in hospital with all the drugs Well I was getting headaches monthly bad ones I couldn’t even handle light As the years went on I got them once every 6 months putting me in hospital Then they started coming on every couple of months then once a month all the way down to 3 a week By this stage my face was numb I couldn’t talk or walk could not have any light, losing memory about 3 months ago I went to a brilliant doctor and I couldn’t see so I needed help going there and walking to him He said to me have you heard of ENDEP I have taken my endep every night since for over 3 months now And only had two very very small headaches I’ve been given a second chance at life I’m very grateful I thank my doctor so very much”

10 / 10
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Fortunate · Taken for 10 years or more June 15, 2020

For Depression: “I have been taking Endep for well over 12 years without any side effects whatsoever. It has helped me greatly my maintenance dose is 100mg. It also helps my pain as well as being able to get about 6 hours sleep at night. l am an elderly person but Endep has contributed to giving me a better quality of life -”

10 / 10
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barsha55 · Taken for 5 to 10 years August 8, 2013

For Pain: “I am taking Endep 100mgs at night for nerve pain in my lower left leg & the outer side of my right leg. The nerve pain was intolerable and I seriously was suicidal. I have been on Endep as well as Baclofen and Epilim, for 7 years & can now enjoy my life so much more. The down side is loss of libido and dry mouth, but without Endep I could not enjoy my life at all.”

9 / 10
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More FAQ

Zubie · Taken for less than 1 month July 10, 2015

For Pain: “My dr prescribed this as my pain from arthritis was constantly waking me up every night from day 1 it has enabled me to get a full nights sleep I will keep taking it as nothing else has worked it does not in any way interfere with daily work, a god send”

9 / 10
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Afranklin · Taken for less than 1 month December 29, 2019

For Pain: “I was prescribed Endep for severe Endometriosis. I was very hesitant with it being used as an anti-depressant in some cases, however I must say it works wonderfully. I have been able to go back to work and get on with my life, I do still have outbursts occasionally but it sure beats living on endone in agony! It is a little harder for me to get out of bed in the mornings although I am fine once up. I sleep better and seem happier, of course with the reduced pain. I haven't lost weight drastically or had any fevers or chills as others prescribed. So far very happy. I am 4 weeks in.”

10 / 10
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Nik85 · Taken for less than 1 month December 13, 2013

For Anxiety and Stress: “I've been taking 20mg of amitriptyline for 2 weeks and I have slept extremely well every night and I have so much more energy during the day. I sleep solid and right through the night which is unusual for me these days as my stressful job and back pain often leaves me anxious and tossing and turning every night and then I end up grumpy, run down and feeling sick as a result. So far it has not helped with my anxiety or depression but getting a good night sleep helps me cope and gives me energy to attend yoga and exercise. I believe the dose may be too small to help the depression. I'm also taking this as it is the most studied antidepressant used during pregnancy and the SSRI's give me insomnia. I have almost no side effects so far.”

6 / 10
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Jandal February 2, 2015

For Insomnia: “I have been taking Endep 10 for approx 3 weeks and have I used a variety of sleeping meds. Endep is the best by far. I take it 3 hours prior to sleep and have no problems getting to sleep and if I do wake during the night I go back to sleep straight away. It can make me a little drowsy in the morning but nothing like other meds.”

9 / 10
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Nickers · Taken for 1 to 6 months October 11, 2018

For Insomnia: “I started taking Endep 10 for insomnia from menopause, this was too weak and no effect so after a week my Doctor upped to Endep 25. This works really well for me and most nights I sleep far more soundly and if I wake up fall back to sleep pretty quickly. Some days I wake up a little bit lethargic and slow to get out of bed but once I'm up I am my usual motivated self. This has worked well for me and I feel heaps better than when I was taking sleeping pills.”

9 / 10
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susieoq October 18, 2013

For Pain: “I have fibromyalgia and take Tramadol 150mg daily. Recently had a flare of trigeminal neuralgia and widespread neuropathic pain and Tramadol was not working for this. Doctor put me back onto Endep, which I had given up previously as the side effects were very strong. Am now on only 5mg at 7pm and find sleep and pain relief much better. Still feel hungover in the morning.”

5 / 10
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trishK August 30, 2007

For Pain: “I have been taking Endep for about 20 yrs. for pain and to help me sleep. I have seen many specialists and gp's over the years and none of them warned me about chronic peridontal disease because of dry mouth. I was on 50mg per day. I had to have three teeth removed. I am now on 25mg. I have many health problems, apparently due to a sero-negative autoimmune disease. I am also having symptoms of headaches, vertigo, dizziness, balance problems, etc. ”

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Hkfygcjb August 10, 2016

For Pain: “I've been taking 10mg Endep for 2 weeks for bladder pain. I may have a mild case of interstitial cystitis but I haven't been officially diagnosed yet. I have found it has worked really well with the pain. I went from being in pain all the time to only a couple of times and it's been manageable. I have dry mouth and an increased appetite from Endep but the worst side effect is constant drowsiness and a general feeling of being drugged up.”

8 / 10
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Anonymous May 9, 2012

For Fibromyalgia: “I had unrefreshing sleep, and needed a lot of it. Endep is awesome as can now get a good night sleep, feel refreshed for a few hours after waking, and decreases my body aches. No negative side effects for me luckily.”

9 / 10
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_Loretta December 8, 2007

For Depression: “Hello, I have only just started using Endep after the sudden onset of a severe depression. I found that it has helped me a great deal. The only side effects that I've had up to this point are a gain in weight (as I wasn't eating properly when depressed) and at night, I'll wake from sleep covered in perspiration - though only from the chest up. I'm hoping with couselling I'll be able to stop taking this medication asap, but it has been a great help. Thanks:)”

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Theg · Taken for less than 1 month March 31, 2016

For Insomnia: “Been on endep 10mg for 4 weeks .for insomnia. Although it helps me sleep the longer I take it the dopier I get during day. Feel like I am permanently sedated. Like my brain is shrinking and my head is full of cotton wool all day. No motivation to do anything..”

1 / 10
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Rhondiga · Taken for 10 years or more December 3, 2014

For Fibromyalgia: “I have been on Endep for 35 years. I have fibromyalgia, chronic fatigue syndrome and plenty more. In the last six months I have been getting very odd symptoms such as the ones provided within this article!( sudden weight gain, inability to eat properly, tiredness, rounded face,weakness, sore mouth and tongue, to slight more depression, At the moment I am on a doctor treadmill ...everyone from my endocrinologist to a neurologist, GP and many more have put their hands up saying I don't know!! The medicines work really well for fibromyalgia but after some time they can work against you! Please look at the list of side effects. I have a lot of them. Good luck!”

6 / 10
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Seehowthisgoes · Taken for less than 1 month April 7, 2018

For Depression: “Hello I've been on probably every SSRI except prozac which all had a short lived outcomes. Finally after 20 years I've been put on an SNRI and its working, started on 10mg endep for appetite which didn't work and given valium for the shakes and tears. Valium stopped working in less than 2 weeks, so I stopped taking it and psych increased the dosage of endep to 25mg, and I'm actually feeling good, after 6 months of awfulness, this might be my answer. Sleeping well, lots of energy, memory and concentration is better and no more teeth grinding. No real side effects except for the first day I started on the 10mg I copped a bad headache but that was it.”

10 / 10
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Mr Mal March 21, 2014

For Insomnia: “I took Endep 25 for headaches. I felt drowsy even the next day. So I went to Endep 10. I need to to take it about 2 hours before sleep. Side effect - ear noise which is going on for over 1 week now after 1 tablet. Going to stop it for a while due to side effect.”

7 / 10
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poey May 23, 2016

For Depression: “I have only been on this drug for two weeks and as yet not noticed any difference with my depression. My anxiety levels are up, I have swooshing, buzzing noises in my ears, I even feel dizzy while seated and even just turning my head from side to side. I have noticed tingling in my fingers. My balance is affected, feeling like a drunk person. My head throbs.”

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pinky · Taken for 1 to 6 months December 26, 2019

For Depression: “My Father has been on Endep (low dose) for a few months and has slept 20 hours a day however he is pain free for the first time in a long time. I don't now if the trade off is worth it but his pain unbearable, but now he has no life. Just sleep.”

6 / 10
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Nickname :-) · Taken for 5 to 10 years October 13, 2019

For Fibromyalgia: “Wonder drug. I was in pain for fibromyalgai for years. Then I took 10 mg of Endep. I was better already next day, without any pain in 2 days. After some time, about 2 years, the pain was slowly coming back. My doctor increased the dosage to 25 mg. Again, it helped immediately. Now, I am away from home and my doctor, pain is getting unbearable. I don’t know what to do. Take two tablets a day? I will be soon home, but it is ruining my holiday. I can’t imagine my life without Endep.”

10 / 10
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affff · Taken for 1 to 6 months October 15, 2015

For Depression: “I was on 75mg of Endep & noticed 2 extreme side effects which lead to me having to stop taking the medication. The first was rapid & excessive weight gain; I gained 6 kgs (13 pounds) within 8 weeks (at 160cm, this is quite a bit of weight). I had no change in my diet, my exercise stayed the same, so the Endep was the only thing that could have caused the weight gain. The second was extreme Night Terrors. These occurred every night & were extremely frightening for myself & family, as I would wake up screaming & kicking every night. This occurred almost immediately after starting the Endep. Since stopping the Endep 2 weeks ago, the Night Terrors have ceased completely, & I have lost 1kg with no change in diet.”

4 / 10
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Gerbras September 20, 2013

For Migraine Prevention: “Started getting migraines at 18. I'm now 46. Vomiting so bad I used to go to hospital 1-2x per month to go on a drip to rehydrate. Made a professional career virtually impossible. Been on Sandomigran for 25 years. Had every possible treatment. Then 5 years ago a hospital locum prescribed Endep. That was the end of my migraines. I was suicidal for 2-3 weeks but then back to normal. I now take 1 x 50mg tab every second night. Endep is brilliant!”

10 / 10
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Lemmingham November 5, 2013

For Fibromyalgia: “I have been on Endep for Fibromyalgia for 10 years. At first the affect was awesome, for the first time in many years I slept properly and had hardly any pain. Over the years though, this has changed. I started off on 50mg per day and over the years had to have it increased to the maximum does of 150mg. Recently I have been having heart palpatations and an increased heart rate. My doctor has put it down to the extended time I have been on Endep at such a high rate. So now I am on a drug to lower my heart rate, which works well, but my doctor is getting me to try to cut down on the Endep with a view of going off it altogether and hopefully also going off the drug that I need to lower my heart rate. It's not working I'm in too much pain”

7 / 10
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aaaaaaaallllllll January 6, 2017

For Insomnia: “Works ok. I have Bulge discs, tear, depression & anxiety . On this I sleep well. Loss of sex drive, anxiety and stress still high. Doesn't help the pain so much in my back. I sleep really well at night after 100mg, but I wake up tired and need to nap for 2-3 hours and in bed by 9:30pm. Just always wanting to sleep and lazy.”

5 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.