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Zofran (Oral Solution)

Generic Name: Ondansetron Oral Solution (on DAN se tron)
Brand Name: Zofran

Medically reviewed on May 2, 2018

Uses of Zofran:

What do I need to tell my doctor BEFORE I take Zofran?

  • If you have an allergy to ondansetron or any other part of Zofran (ondansetron oral solution).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have a long QT on ECG.
  • If you are taking apomorphine.

This is not a list of all drugs or health problems that interact with Zofran (ondansetron oral solution).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zofran (ondansetron oral solution) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Zofran?

  • Tell all of your health care providers that you take Zofran (ondansetron oral solution). This includes your doctors, nurses, pharmacists, and dentists.
  • You may need to have an ECG checked before starting Zofran (ondansetron oral solution) and while taking it. Talk with your doctor.
  • If you are 65 or older, use Zofran (ondansetron oral solution) with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Zofran (ondansetron oral solution) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Zofran) best taken?

Use Zofran (ondansetron oral solution) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Measure liquid doses carefully. Use the measuring device that comes with Zofran (ondansetron oral solution). If there is none, ask the pharmacist for a device to measure Zofran (ondansetron oral solution).

What do I do if I miss a dose?

  • If you take Zofran (ondansetron oral solution) on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times Zofran (ondansetron oral solution) is taken on an as needed basis. Do not take more often than told by the doctor.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Slow heartbeat.
  • Numbness and tingling.
  • Belly pain.
  • Trouble passing urine.
  • Trouble controlling body movements.
  • Change in eyesight.
  • Feeling very sleepy.
  • Seizures.
  • Dizziness.
  • Fever or chills.
  • A type of abnormal heartbeat (prolonged QT interval) can happen with Zofran (ondansetron oral solution). Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.
  • A very bad and sometimes deadly health problem called serotonin syndrome may happen. The risk may be greater if you take Zofran (ondansetron oral solution) with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.

What are some other side effects of Zofran?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Feeling tired or weak.
  • Hard stools (constipation).
  • Loose stools (diarrhea).
  • Feeling sleepy.
  • Anxiety.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Zofran?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Protect from light.
  • Store upright with the cap on.
  • Store in original container.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Zofran (ondansetron oral solution), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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