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Generic name: Liothyronine Injectionlye-oh-THYE-roe-neen ]
Drug class: Thyroid drugs

Medically reviewed by Last updated on Mar 16, 2023.


  • Do not use Triostat (liothyronine injection) to treat obesity or for weight loss. Very bad and sometimes deadly side effects may happen with Triostat (liothyronine injection) if it is taken in large doses or with other drugs for weight loss. Talk with the doctor.

Uses of Triostat:

  • It is used to add thyroid hormone to the body.
  • It is used to manage thyroid cancer.
  • It is used to test for thyroid problems.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Triostat?

  • If you have an allergy to liothyronine or any other part of Triostat (liothyronine injection).
  • If you are allergic to Triostat (liothyronine injection); any part of Triostat (liothyronine injection); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have any of these health problems: Overactive thyroid gland or weak adrenal gland.

This is not a list of all drugs or health problems that interact with Triostat (liothyronine injection).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Triostat (liothyronine injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Triostat?

  • Tell all of your health care providers that you take Triostat (liothyronine injection). This includes your doctors, nurses, pharmacists, and dentists.
  • Do not run out of Triostat (liothyronine injection).
  • It may take several weeks to see the full effects.
  • If you have high blood sugar (diabetes), Triostat (liothyronine injection) may sometimes raise blood sugar. Talk with your doctor about how to keep your blood sugar under control.
  • Check your blood sugar as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may cause weak bones (osteoporosis) with doses that are too high. The risk may be higher in women who have been through menopause. Talk with your doctor to see if you have a higher risk of weak bones or if you have any questions.
  • If you are 65 or older, use Triostat (liothyronine injection) with care. You could have more side effects.
  • This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.
  • This medicine is not approved for use in children. Talk with the doctor.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Triostat) best taken?

Use Triostat (liothyronine injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a vein.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of too much thyroid hormone in the body. This includes feeling bothered by heat; shaky; tired or weak; more or less hungry; or nervous, excitable, or irritable. This also includes weight loss; fever; sweating a lot; headache; anxiety; emotional ups and downs; trouble sleeping; muscle weakness or cramps; fast or abnormal heartbeat; chest pain or pressure; shortness of breath, a big weight gain, or swelling in the arms or legs; diarrhea; throwing up; stomach cramps; flushing; bone pain; period (menstrual) changes; or fertility problems.

What are some other side effects of Triostat?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Hair loss may happen in some people in the first few months of using Triostat (liothyronine injection). This most often goes back to normal.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Triostat?

  • If you need to store Triostat (liothyronine injection) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Triostat (liothyronine injection), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.