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Triostat Side Effects

Generic Name: liothyronine

Note: This document contains side effect information about liothyronine. Some of the dosage forms listed on this page may not apply to the brand name Triostat.

For the Consumer

Applies to liothyronine: oral tablet

Along with its needed effects, liothyronine (the active ingredient contained in Triostat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following symptoms of overdose occur while taking liothyronine:

  • Arm, back or jaw pain
  • changes in appetite
  • changes in menstrual periods
  • chest pain or discomfort
  • chest tightness or heaviness
  • cold clammy skin
  • confusion
  • decreased urine output
  • diarrhea
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • hand tremors
  • headache
  • increased bowel movements
  • irregular breathing
  • irritability
  • leg cramps
  • lightheadedness
  • menstrual changes
  • nausea
  • nervousness
  • sensitivity to heat
  • shortness of breath
  • sweating
  • swelling of face, fingers, feet, or lower legs
  • troubled breathing
  • trouble sleeping
  • vomiting
  • weak pulse
  • weight gain
  • weight loss
  • wheezing

For Healthcare Professionals

Applies to liothyronine: compounding powder, intravenous solution, oral tablet


Reported side effects are usually indicative of excessive dosage and will usually disappear when the dose is reduced or treatment is stopped.[Ref]


Common (1% to 10%): Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, myocardial infarction
Frequency not reported: Angina, congestive heart failure, hypertension, flushing, palpitation[Ref]

Nervous system

Frequency not reported: Headache, tremor, benign intracranial hypertension[Ref]


Frequency not reported: Allergic skin reaction, sweating, rash pruritus, transient hair loss[Ref]


Frequency not reported: Twitching, muscle cramps, muscle weakness, craniostenosis, premature closure of epiphysis[Ref]


Frequency not reported: Diarrhea, vomiting[Ref]


Frequency not reported: Hypersensitivity reaction[Ref]


Frequency not reported: Phlebitis[Ref]


Frequency not reported: Restlessness, excitability, insomnia[Ref]


Frequency not reported: Menstruation irregular[Ref]


Frequency not reported: Fever, edema, weight loss, heat intolerance[Ref]


1. "Product Information. Triostat (liothyronine)." JHP Pharmaceuticals, Saddle River, NJ.

2. "Product Information. Cytomel (liothyronine)." Monarch Pharmaceuticals Inc, Bristol, TN.

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Triostat may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.