Triostat Side Effects

Generic name: liothyronine

Medically reviewed by Drugs.com. Last updated on Feb 15, 2025.

Note: This document provides detailed information about Triostat Side Effects associated with liothyronine. Some dosage forms listed on this page may not apply specifically to the brand name Triostat.

Applies to liothyronine: oral tablet.

Other dosage forms:

• intravenous solution

Precautions

It is very important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests will be needed to check for unwanted effects.

Liothyronine should not be used for the treatment of obesity or for the purpose of losing weight. This medicine is ineffective for weight reduction and when taken in larger amounts, may cause more serious unwanted effects.

Call your doctor right away if you start to have chest pain, fast or irregular heartbeat, excessive sweating, difficulty with breathing, heat intolerance, nervousness, leg cramps, headache, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, fever, changes in menstrual periods, hives, or skin rash. These could be symptoms of too much medicine in your body.

This medicine may cause severe hypothyroidism, called myxedema coma, which may be life-threatening and requires immediate medical attention. Check with your doctor right away if you have the following symptoms: weakness, confusion or non-responsiveness, feeling cold, low body temperature, swelling of the body, especially the face, tongue, and lower legs, or difficulty breathing.

For patients with diabetes: It is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor right away if you notice any changes in your sugar levels.

If you think you have become pregnant while using this medicine, tell your doctor right away. You may need a larger dose of liothyronine (the active ingredient contained in Triostat) while you are pregnant.

Women who are post-menopausal or who use this medicine for a long time may have some bone loss, which could lead to osteoporosis. Talk with your doctor if you have questions or concerns about this.

A temporary loss of hair may occur during the first few months of liothyronine treatment. Ask your doctor about this if you have any concerns.

Make sure any doctor or dentist who treats you knows that you or your child are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Triostat

Along with its needed effects, liothyronine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking liothyronine:

Get emergency help immediately if any of the following symptoms of overdose occur while taking liothyronine:

Symptoms of overdose

• cold, clammy skin
• confusion about identity, place, and time
• difficulty in speaking
• dizziness
• double vision
• fast, weak pulse
• headache
• inability to move the arms, legs, or facial muscles
• inability to speak
• lightheadedness
• loss of consciousness
• nervousness
• seizure
• sensitivity to heat
• slow speech
• sweating
• trouble sleeping
• weight loss

Other side effects of Triostat

Some side effects of liothyronine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to liothyronine: compounding powder, intravenous solution, oral tablet.

General adverse events

Reported side effects are usually indicative of excessive dosage and will usually disappear when the dose is reduced or treatment is stopped.^[Ref]

Cardiovascular

• Common (1% to 10%): Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, myocardial infarction
• Frequency not reported: Angina, congestive heart failure, hypertension, flushing, palpitation^[Ref]

Nervous system

• Frequency not reported: Headache, tremor, benign intracranial hypertension^[Ref]

Dermatologic

• Frequency not reported: Allergic skin reaction, sweating, rash pruritus, transient hair loss^[Ref]

Musculoskeletal

• Frequency not reported: Twitching, muscle cramps, muscle weakness, craniostenosis, premature closure of epiphysis^[Ref]

Gastrointestinal

• Frequency not reported: Diarrhea, vomiting^[Ref]

Immunologic

• Frequency not reported: Hypersensitivity reaction^[Ref]

Local

• Frequency not reported: Phlebitis^[Ref]

Psychiatric

• Frequency not reported: Restlessness, excitability, insomnia^[Ref]

Genitourinary

• Frequency not reported: Menstruation irregular^[Ref]

Other

• Frequency not reported: Fever, edema, weight loss, heat intolerance^[Ref]

See also:

Further information

Triostat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer