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Tofacitinib Extended-Release Tablets

Generic name: Tofacitinib Extended-Release Tablets [ toe-fa-SYE-ti-nib ]
Brand name: Xeljanz XR
Drug class: Antirheumatics

Medically reviewed by Last updated on Apr 24, 2024.


  • Severe infections like tuberculosis, shingles, fungal infections and other bacterial or viral infections have happened in patients who take this medicine (tofacitinib extended-release tablets). Sometimes, this could be deadly. The risk is greater if you also take drugs that suppress the immune system like methotrexate or corticosteroids. If you get a bad infection, your doctor may stop this medicine (tofacitinib extended-release tablets) until the infection is under control. Call your doctor right away if you have fever, chills, or sweating; cough; muscle aches; shortness of breath; more sputum or change in color of sputum; red, warm, swollen, painful, or blistered skin; weight loss; stomach pain; diarrhea; pain with passing urine or passing urine more often; or feeling tired or weak.
  • TB (tuberculosis) has been seen in patients started on this medicine (tofacitinib extended-release tablets). These patients were exposed to TB in the past, but never got the infection. You will be tested to see if you have been exposed to TB before starting this medicine (tofacitinib extended-release tablets).
  • A greater risk of death was seen in some people who took higher than recommended doses of this medicine (tofacitinib extended-release tablets) for rheumatoid arthritis. These people were 50 years of age and older. They also had at least 1 heart disease risk factor. Tell your doctor if you have ever had heart problems.
  • Blood clots have happened with this medicine (tofacitinib extended-release tablets). A raised risk of blood clots was seen in a study in people with rheumatoid arthritis who were taking a higher than recommended dose. These people were 50 years of age or older and also had at least 1 heart disease risk factor. Rarely, blood clots in the lungs have also happened in people with ulcerative colitis. Sometimes, blood clots have been deadly. Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, coldness, change of color, or pain in a leg or arm; trouble speaking, swallowing, or thinking; weakness on 1 side of the body; change in balance; drooping on one side of the face; or change in eyesight.
  • Lymphoma, skin cancer, and other types of cancer have happened in people treated with this medicine (tofacitinib extended-release tablets).
  • If you have had a kidney transplant and take drugs that work on the immune system, you are at a greater risk for a problem with certain white blood cells growing out of control called post-transplant lymphoproliferative disorder caused by the Epstein Barr virus. Talk with your doctor.

Uses of Tofacitinib Extended-Release Tablets:

What do I need to tell my doctor BEFORE I take Tofacitinib Extended-Release Tablets?

This is not a list of all drugs or health problems that interact with this medicine (tofacitinib extended-release tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (tofacitinib extended-release tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tofacitinib Extended-Release Tablets?

How is this medicine (Tofacitinib Extended-Release Tablets) best taken?

Use this medicine (tofacitinib extended-release tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

What do I do if I miss a dose?

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

What are some other side effects of Tofacitinib Extended-Release Tablets?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tofacitinib Extended-Release Tablets?

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.