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Generic Name: Edoxaban (e DOX a ban)
Brand Name: Savaysa

Medically reviewed by Last updated on Sep 29, 2020.


  • Your doctor will check how well your kidneys work. Based on how well your kidneys work, your dose may need to be changed or you may need to take a different blood thinner. For atrial fibrillation, Savaysa (edoxaban) may not work as well to prevent stroke in people whose kidneys work well. If you have questions, talk with your doctor.
  • People who have any type of spinal or epidural procedure are more likely to have bleeding problems around the spine when already on this drug. This bleeding rarely happens, but can lead to not being able to move body (paralysis) long-term or paralysis that will not go away. The risk is raised in people who have problems with their spine, a certain type of epidural catheter, or have had spinal surgery. The risk is also raised in people who take any other drugs that may affect how the blood clots like blood-thinner drugs (like warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs). Talk with the doctor.
  • Tell your doctor you use Savaysa (edoxaban) before you have a spinal or epidural procedure. Call your doctor right away if you have any signs of nerve problems like back pain, numbness or tingling, muscle weakness, paralysis, or loss of bladder or bowel control.
  • Talk with your doctor if you have recently had or will be having a spinal or epidural procedure. Some time may need to pass between the use of Savaysa (edoxaban) and your procedure. Talk with your doctor.
  • Do not stop taking Savaysa (edoxaban) without talking to the doctor who ordered it for you. Stopping Savaysa (edoxaban) when you are not supposed to may raise the chance of blood clots. This includes stroke in certain people. You may need to stop Savaysa (edoxaban) before certain types of dental or health care. Your doctor will tell you when to start taking it again. Follow what your doctor tells you closely.

Uses of Savaysa:

  • It is used to treat blood clots.
  • It is used to lower the risk of stroke and blood clots.

What do I need to tell my doctor BEFORE I take Savaysa?

  • If you are allergic to Savaysa (edoxaban); any part of Savaysa (edoxaban); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have active bleeding.
  • If you have heart valve problems.
  • If you have had a heart valve replaced.
  • If you have any of these health problems: Kidney disease or liver disease.
  • If you are taking rifampin.
  • If you are breast-feeding. Do not breast-feed while you take Savaysa (edoxaban).

This is not a list of all drugs or health problems that interact with Savaysa (edoxaban).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Savaysa (edoxaban) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Savaysa?

  • Tell all of your health care providers that you take Savaysa (edoxaban). This includes your doctors, nurses, pharmacists, and dentists. This medicine may need to be stopped before certain types of surgery as your doctor has told you. If Savaysa (edoxaban) is stopped, your doctor will tell you when to start taking Savaysa (edoxaban) again after your surgery or procedure.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor. Rarely, some bleeding problems have been deadly.
  • If you fall or hurt yourself, or if you hit your head, call your doctor right away. Talk with your doctor even if you feel fine.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Savaysa (edoxaban) while you are pregnant.
  • If you used Savaysa (edoxaban) when you were pregnant, tell your baby's doctor.

How is this medicine (Savaysa) best taken?

Use Savaysa (edoxaban) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Keep taking Savaysa (edoxaban) as you have been told by your doctor or other health care provider, even if you feel well.
  • If you are not able to swallow tablets, the tablets can be crushed and mixed in 2 to 3 ounces (60 to 90 mL) of water. You may also mix crushed tablets into applesauce. Take right away after mixing.
  • Those who have feeding tubes may use Savaysa (edoxaban). Use as you have been told. Flush the feeding tube after Savaysa (edoxaban) is given.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it on the same day you missed the dose.
  • If you do not think about the missed dose until the next day, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Pale skin.
  • Very bad headache.
  • Feeling tired or weak.

What are some other side effects of Savaysa?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Savaysa?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Savaysa (edoxaban) is refilled. If you have any questions about Savaysa (edoxaban), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.