Generic name: Estrogens (Conjugated/Equine, Topical) [ ES-troe-jenz-KON-joo-gate-ed, EE-kwine ]
Brand name: Premarin
Drug classes: Estrogens, Miscellaneous vaginal agents
Medically reviewed by Drugs.com. Last updated on Aug 5, 2022.
- Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
- Do not use estrogens to prevent heart disease or dementia. Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, ovarian cancer, a blood clot, or dementia.
- Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
Uses of Premarin:
- It is used to prevent or lower the signs of the change of life (menopause).
- It is used to treat vaginal irritation and dryness.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Premarin?
- If you have an allergy to estrogens (conjugated/equine) or any other part of Premarin (estrogens (conjugated/equine, topical)).
- If you are allergic to Premarin (estrogens (conjugated/equine, topical)); any part of Premarin (estrogens (conjugated/equine, topical)); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have had any of these health problems: Bleeding disorder, blood clots, a higher risk of having a blood clot, breast cancer, liver problems or liver tumor, heart attack, stroke, or a tumor where estrogen makes it grow.
- If you have unexplained vaginal bleeding.
- If you are pregnant or may be pregnant. Do not take Premarin (estrogens (conjugated/equine, topical)) if you are pregnant.
This is not a list of all drugs or health problems that interact with Premarin (estrogens (conjugated/equine, topical)).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Premarin (estrogens (conjugated/equine, topical)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Premarin?
- Tell all of your health care providers that you take Premarin (estrogens (conjugated/equine, topical)). This includes your doctors, nurses, pharmacists, and dentists.
- This medicine may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
- High triglyceride levels have happened with Premarin (estrogens (conjugated/equine, topical)). Tell your doctor if you have ever had high triglyceride levels.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have a bone density test as you have been told by your doctor. Talk with your doctor.
- Be sure to have regular breast exams and gynecology check-ups. You will also need to do breast self-exams as you have been told.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Premarin (estrogens (conjugated/equine, topical)).
- Limit your drinking of alcohol.
- Avoid cigarette smoking. Smoking raises the chance of heart disease. Talk with your doctor.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- If you are 65 or older, use Premarin (estrogens (conjugated/equine, topical)) with care. You could have more side effects.
- This medicine is not approved for use in children. Talk with the doctor.
- Condoms, diaphragms, or cervical caps may not work to prevent pregnancy. Use some other kind of birth control while taking Premarin (estrogens (conjugated/equine, topical)).
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Premarin) best taken?
Use Premarin (estrogens (conjugated/equine, topical)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Use Premarin (estrogens (conjugated/equine, topical)) at the same time of day.
- There may be days when you will not take Premarin (estrogens (conjugated/equine, topical)).
- Use cream vaginally.
What do I do if I miss a dose?
- Use a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not put on 2 doses or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever with chills; bloating; or very upset stomach or throwing up.
- Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Pelvic pain.
- Change in eyesight.
- Loss of eyesight.
- Bulging eyes.
- Change in how contact lenses feel in the eyes.
- A lump in the breast, breast pain or soreness, or nipple discharge.
- Breast pain.
- Vaginal itching or discharge.
- Vaginal bleeding that is not normal.
- Very bad vaginal irritation.
- Memory problems or loss.
- Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
What are some other side effects of Premarin?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hair loss.
- Breast soreness.
- Upset stomach or throwing up.
- Stomach cramps.
- Vaginal bleeding or spotting.
- Vaginal irritation.
- This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Premarin?
- Store at room temperature.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Premarin (estrogens (conjugated/equine, topical)), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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