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Conjugated estrogens topical Side Effects

For the Consumer

Applies to conjugated estrogens topical: vaginal cream

In addition to its needed effects, some unwanted effects may be caused by conjugated estrogens topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking conjugated estrogens topical:

More common:
  • Breast pain
  • change in vaginal discharge
  • cough or hoarseness
  • fever or chills
  • increased clear or white vaginal discharge
  • itching of the vagina or genital area
  • lower back or side pain
  • pain during sexual intercourse
  • pain or feeling of pressure in the pelvis
  • painful or difficult urination
  • thick, white vaginal discharge with no odor or with a mild odor
  • vaginal bleeding
Less common:
  • Feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • headache
  • sweating
Incidence not known:
  • Abdominal or stomach bloating
  • abnormal uterine bleeding or spotting
  • acne
  • anxiety
  • bloody or cloudy urine
  • breast tenderness, enlargement, pain, or discharge
  • chest pain or discomfort
  • decreased vision or other changes in vision
  • difficulty with swallowing
  • enlargement of the penis or testes
  • fast heartbeat
  • frequent urge to urinate
  • growth of pubic hair
  • hives
  • itching
  • itching of the vagina or outside genitals
  • nausea
  • pain during sexual intercourse
  • pain or discomfort in the arms, jaw, back, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid increase in height
  • shortness of breath
  • stomach pain
  • sudden shortness of breath or troubled breathing
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Minor Side Effects

Some of the side effects that can occur with conjugated estrogens topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • back pain
  • diarrhea
  • headache
  • lack or loss of strength
Less common:
  • Body aches or pain
  • congestion
  • increased dryness or soreness of the throat
  • runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
Incidence not known:
  • Abdominal or stomach cramps
  • changes in weight
  • decreased or increased interest in sexual intercourse
  • depression
  • difficulty with moving
  • headache, severe and throbbing
  • heavy bleeding
  • inability to have or keep an erection
  • increased hair growth, especially on the face
  • irritability
  • itching of the vagina or genitals
  • leg cramps
  • loss of scalp hair
  • loss or increase in sexual ability, desire, drive, or performance
  • mood changes
  • muscle pain or stiffness
  • nervousness
  • pain
  • pain in the joints
  • patchy brown or dark brown discoloration of the skin
  • poor insight and judgment
  • problems with memory or speech
  • swelling of the breasts or breast soreness in both females and males
  • trouble recognizing objects
  • trouble thinking and planning
  • weakness

For Healthcare Professionals

Applies to conjugated estrogens topical: vaginal cream with applicator

Genitourinary

Common (1% to 10%): Breast pain, leukorrhea, dysuria, vaginal hemorrhage, vaginal moniliasis, vaginitis, vulvovaginal disorder
Uncommon (0.1% to 1%): Breast enlargement, urinary urgency
Postmarketing reports: Abnormal uterine bleeding or spotting, dysmenorrhea or pelvic pain, increase in size of uterine leiomyomata, change in cervical secretion, cystitis-like syndrome, application site reactions of vulvovaginal discomfort (including burning, irritation, and genital pruritus), endometrial hyperplasia, endometrial cancer, precocious puberty, breast tenderness, breast discharge, fibrocystic breast changes, breast cancer, gynecomastia in males[Ref]

Cardiovascular

Common (1% to 10%): Vasodilation
Postmarketing reports: Deep vein thrombosis, myocardial infarction, increase in blood pressure[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Dizziness
Postmarketing reports: Stroke, migraine, dementia[Ref]

Gastrointestinal

Postmarketing reports: Nausea, vomiting, abdominal cramps, bloating[Ref]

Dermatologic

Common (1% to 10%): Acne, pruritus
Postmarketing reports: Chloasma that may persist when drug is discontinued, loss of scalp hair, hirsutism, rash[Ref]

Other

Common (1% to 10%): Moniliasis, pain
Postmarketing reports: Increase or decrease in weight, edema[Ref]

Psychiatric

Postmarketing reports: Mental depression, mood disturbances, nervousness, irritability, changes in libido[Ref]

Respiratory

Postmarketing reports: Pulmonary embolism, exacerbation of asthma[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramp
Postmarketing reports: Arthralgias, leg cramps[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity[Ref]

Hepatic

Postmarketing reports: Increased incidence of gallbladder disease[Ref]

Metabolic

Postmarketing reports: Glucose intolerance, increased triglycerides[Ref]

Ocular

Postmarketing reports: Retinal vascular thrombosis, intolerance to contact lenses[Ref]

References

1. "Product Information. Premarin Vaginal (conjugated estrogens topical)." Wyeth Laboratories, Philadelphia, PA.

Not all side effects for conjugated estrogens topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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