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Conjugated estrogens topical Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 30, 2023.

Applies to conjugated estrogens topical: vaginal cream.

Warning

Vaginal route (Cream)

Endometrial Cancer, Cardiovascular Disorders, Breast Cancer and Probable DementiaEstrogen-Alone TherapyThere is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens.Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia.Women's Health Initiative estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis.The Women’s Health Initiative Memory Study estrogen-alone ancillary study of Women’s Health Initiative reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.Estrogen Plus Progestin TherapyEstrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia.The Women’s Health Initiative estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism, and myocardial infarction.The Women’s Health Initiative estrogen plus progestin substudy reported increased risks of invasive breast cancer.The Women’s Health Initiative Memory Study estrogen plus progestin ancillary study of Women’s Health Initiative reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.

Serious side effects

Along with its needed effects, conjugated estrogens topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking conjugated estrogens topical:

More common

Less common

Incidence not known

Other side effects

Some side effects of conjugated estrogens topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to conjugated estrogens topical: vaginal cream with applicator.

Genitourinary

Common (1% to 10%): Breast pain, leukorrhea, dysuria, vaginal hemorrhage, vaginal moniliasis, vaginitis, vulvovaginal disorder

Uncommon (0.1% to 1%): Breast enlargement, urinary urgency

Postmarketing reports: Abnormal uterine bleeding or spotting, dysmenorrhea or pelvic pain, increase in size of uterine leiomyomata, change in cervical secretion, cystitis-like syndrome, application site reactions of vulvovaginal discomfort (including burning, irritation, and genital pruritus), endometrial hyperplasia, endometrial cancer, precocious puberty, breast tenderness, breast discharge, fibrocystic breast changes, breast cancer, gynecomastia in males[Ref]

Cardiovascular

Common (1% to 10%): Vasodilation

Postmarketing reports: Deep vein thrombosis, myocardial infarction, increase in blood pressure[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Postmarketing reports: Stroke, migraine, dementia[Ref]

Gastrointestinal

Postmarketing reports: Nausea, vomiting, abdominal cramps, bloating[Ref]

Dermatologic

Common (1% to 10%): Acne, pruritus

Postmarketing reports: Chloasma that may persist when drug is discontinued, loss of scalp hair, hirsutism, rash[Ref]

Other

Common (1% to 10%): Moniliasis, pain

Postmarketing reports: Increase or decrease in weight, edema[Ref]

Psychiatric

Postmarketing reports: Mental depression, mood disturbances, nervousness, irritability, changes in libido[Ref]

Respiratory

Postmarketing reports: Pulmonary embolism, exacerbation of asthma[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramp

Postmarketing reports: Arthralgias, leg cramps[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity[Ref]

Hepatic

Postmarketing reports: Increased incidence of gallbladder disease[Ref]

Metabolic

Postmarketing reports: Glucose intolerance, increased triglycerides[Ref]

Ocular

Postmarketing reports: Retinal vascular thrombosis, intolerance to contact lenses[Ref]

References

1. (2017) "Product Information. Premarin Vaginal (conjugated estrogens topical)." Wyeth Laboratories

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.